Cloning, experession and chromosomal localization of a member of the human cytochrome P450IIC gene sub‐family

E. A. Shephard; I. R. Phillips; I. Santisteban; C. N.A. Palmer; S. Povey

doi:10.1111/j.1469-1809.1989.tb01119.x

Cloning, experession and chromosomal localization of a member of the human cytochrome P450IIC gene sub‐family

E. A. Shephard, I. R. Phillips, I. Santisteban, C. N.A. Palmer, S. Povey

Population Health and Genomics

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Abstract

We have isolatd and sequenced a cDNA clone (pB8) that codes for a novel member of the dcytochrome P450IIC sub‐family of man. Analysis, by Southern blot hybridization, of DNA isolated from a panel of nine independent human‐rodent somatic cell hybrids demonstrated that the corresponding gene (CYP2C) is located on human chromosome 10. Northern blot hybridization of RNA isolated from human livers revealed a 10‐fold inter‐indicidual variation in the expression of the gene.

Original language	English
Pages (from-to)	23-31
Number of pages	9
Journal	Annals of Human Genetics
Volume	53
Issue number	1
DOIs	https://doi.org/10.1111/j.1469-1809.1989.tb01119.x
Publication status	Published - Jan 1989

ASJC Scopus subject areas

Genetics
Genetics(clinical)

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10.1111/j.1469-1809.1989.tb01119.x

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AU - Santisteban, I.

AU - Palmer, C. N.A.

AU - Povey, S.

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AB - We have isolatd and sequenced a cDNA clone (pB8) that codes for a novel member of the dcytochrome P450IIC sub‐family of man. Analysis, by Southern blot hybridization, of DNA isolated from a panel of nine independent human‐rodent somatic cell hybrids demonstrated that the corresponding gene (CYP2C) is located on human chromosome 10. Northern blot hybridization of RNA isolated from human livers revealed a 10‐fold inter‐indicidual variation in the expression of the gene.

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Cloning, experession and chromosomal localization of a member of the human cytochrome P450IIC gene sub‐family

Abstract

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