Cloning, experession and chromosomal localization of a member of the human cytochrome P450IIC gene sub‐family

TY - JOUR

T1 - Cloning, experession and chromosomal localization of a member of the human cytochrome P450IIC gene sub‐family

AU - Shephard, E. A.

AU - Phillips, I. R.

AU - Santisteban, I.

AU - Palmer, C. N.A.

AU - Povey, S.

PY - 1989/1

Y1 - 1989/1

N2 - We have isolatd and sequenced a cDNA clone (pB8) that codes for a novel member of the dcytochrome P450IIC sub‐family of man. Analysis, by Southern blot hybridization, of DNA isolated from a panel of nine independent human‐rodent somatic cell hybrids demonstrated that the corresponding gene (CYP2C) is located on human chromosome 10. Northern blot hybridization of RNA isolated from human livers revealed a 10‐fold inter‐indicidual variation in the expression of the gene.

AB - We have isolatd and sequenced a cDNA clone (pB8) that codes for a novel member of the dcytochrome P450IIC sub‐family of man. Analysis, by Southern blot hybridization, of DNA isolated from a panel of nine independent human‐rodent somatic cell hybrids demonstrated that the corresponding gene (CYP2C) is located on human chromosome 10. Northern blot hybridization of RNA isolated from human livers revealed a 10‐fold inter‐indicidual variation in the expression of the gene.

UR - https://www.scopus.com/pages/publications/0024552284

U2 - 10.1111/j.1469-1809.1989.tb01119.x

DO - 10.1111/j.1469-1809.1989.tb01119.x

M3 - Article

C2 - 2729895

AN - SCOPUS:0024552284

SN - 0003-4800

VL - 53

SP - 23

EP - 31

JO - Annals of Human Genetics

JF - Annals of Human Genetics

IS - 1

ER -