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Abstract
Eukaryotic cells possess considerable internal complexity, differentiating them from prokaryotes. Eukaryogenesis, an evolutionary transitional period culminating in the last eukaryotic common ancestor (LECA), marked the origin of the eukaryotic endomembrane system. LECA is reconstructed as possessing intracellular complexity akin to modern eukaryotes. Construction of endomembrane compartments involved three key gene families: coatomer, BAR-domain proteins, and ESCRT. Each has a distinct evolutionary origin, but of these coatomer and BAR proteins are eukaryote specific, while ESCRT has more ancient origins. We discuss the structural motifs defining these three membrane-coating complexes and suggest that compared with BAR and ESCRT, the coatomer architecture had a unique ability to be readily and considerably modified, unlocking functional diversity and enabling the development of the eukaryotic cell.
Original language | English |
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Article number | pe8 |
Number of pages | 5 |
Journal | Molecular Biology of the Cell |
Volume | 33 |
Issue number | 14 |
Early online date | 18 Nov 2022 |
DOIs | |
Publication status | Published - 1 Dec 2022 |
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Dive into the research topics of 'Coatomer in the universe of cellular complexity'. Together they form a unique fingerprint.Projects
- 1 Finished
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A Systems Approach for Understanding Cell Surface Dynamics in Trypanosomes (Investigator Award)
Field, M. (Investigator)
1/10/17 → 31/03/24
Project: Research