TY - JOUR
T1 - Cognitive ability and brain structure in type 1 diabetes
T2 - relation to microangiopathy and preceding severe hypoglycemia
AU - Ferguson, Stewart C.
AU - Blane, Annette
AU - Perros, Petros
AU - McCrimmon, Rory J.
AU - Best, Jonathan J. K.
AU - Wardlaw, Joanna
AU - Deary, Ian J.
AU - Frier, Brian M.
N1 - M1 - 1
Ferguson, Stewart C Blane, Annette Perros, Petros McCrimmon, Rory J Best, Jonathan J K Wardlaw, Joanna Deary, Ian J Frier, Brian M eng Research Support, Non-U.S. Gov't 2002/12/28 04:00 Diabetes. 2003 Jan;52(1):149-56.
PY - 2003/1
Y1 - 2003/1
N2 - Type 1 diabetes is associated with chronic hyperglycemia and exposure to intermittent severe hypoglycemia. The long-term cerebral effects of these consequences of diabetes are ill defined. In this study, the history of preceding severe hypoglycemia and the presence of background retinopathy were examined in relation to cognitive ability (neuropsychological test battery) and brain structure (magnetic resonance imaging) in a cross-sectional evaluation of 74 young people with type 1 diabetes. Participants differed by their severe hypoglycemia exposure and degree of diabetic retinopathy and none had previous neuropsychological pathology. Severe hypoglycemia did not influence cognitive ability or brain structure. Background diabetic retinopathy was associated with small focal white-matter hyperintensities in the basal ganglia (33.3 vs. 4.7%, after correction for age, P = 0.005) and significant cognitive disadvantage, affecting fluid intelligence (P = 0.008, Eta(2) = 0.14), information processing (P = 0.001, Eta(2) = 0.22), and attention and concentration ability (P = 0.03, Eta(2) = 0.09). In conclusion, recurrent exposure to severe hypoglycemia alone in young people with type 1 diabetes had no detrimental impact on brain structure or function over the duration of diabetes examined. Chronic hyperglycemia (inferred by the presence of background diabetic retinopathy) may affect brain structure and function.
AB - Type 1 diabetes is associated with chronic hyperglycemia and exposure to intermittent severe hypoglycemia. The long-term cerebral effects of these consequences of diabetes are ill defined. In this study, the history of preceding severe hypoglycemia and the presence of background retinopathy were examined in relation to cognitive ability (neuropsychological test battery) and brain structure (magnetic resonance imaging) in a cross-sectional evaluation of 74 young people with type 1 diabetes. Participants differed by their severe hypoglycemia exposure and degree of diabetic retinopathy and none had previous neuropsychological pathology. Severe hypoglycemia did not influence cognitive ability or brain structure. Background diabetic retinopathy was associated with small focal white-matter hyperintensities in the basal ganglia (33.3 vs. 4.7%, after correction for age, P = 0.005) and significant cognitive disadvantage, affecting fluid intelligence (P = 0.008, Eta(2) = 0.14), information processing (P = 0.001, Eta(2) = 0.22), and attention and concentration ability (P = 0.03, Eta(2) = 0.09). In conclusion, recurrent exposure to severe hypoglycemia alone in young people with type 1 diabetes had no detrimental impact on brain structure or function over the duration of diabetes examined. Chronic hyperglycemia (inferred by the presence of background diabetic retinopathy) may affect brain structure and function.
U2 - 10.2337/diabetes.52.1.149
DO - 10.2337/diabetes.52.1.149
M3 - Article
SN - 0012-1797
VL - 52
SP - 149
EP - 156
JO - Diabetes
JF - Diabetes
IS - 1
ER -
