Cohort profile: Design and methods in the eye and vision consortium of UK Biobank

UK Biobank Eye and Vision Consortium, Sharon Yu Lin Chua, Dhanes Thomas, Naomi Allen, Andrew Lotery, Parul Desai, Praveen Patel, Zaynah Muthy, Cathie Sudlow, Tunde Peto, Peng Tee Khaw, Paul J. Foster (Lead / Corresponding author)

Research output: Contribution to journalArticle

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Abstract

Purpose To describe the rationale, methods and research potential of eye and vision measures available in UK Biobank. Participants UK Biobank is a large, multisite, prospective cohort study. Extensive lifestyle and health questionnaires, a range of physical measures and collection of biological specimens are collected. The scope of UK Biobank was extended midway through data collection to include assessments of other measures of health, including eyes and vision. The eye assessment at baseline included questionnaires detailing past ophthalmic and family history, measurement of visual acuity, refractive error and keratometry, intraocular pressure (IOP), corneal biomechanics, spectral domain optical coherence tomography (OCT) of the macula and a disc-macula fundus photograph. Since recruitment, UK Biobank has collected accelerometer data and begun multimodal imaging data (including brain, heart and abdominal MRI) in 100 000 participants. Dense genotypic data and a panel of 20 biochemistry measures are available, and linkage to medical health records for the full cohort has begun. Findings to date A total of 502 665 people aged between 40 and 69 were recruited to participate in UK Biobank. Of these, 117 175 took part in baseline assessment of vision, IOP, refraction and keratometry. A subgroup of 67 321 underwent OCT and retinal photography. The introduction of eye and vision measures in UK Biobank was accompanied by intensive training, support and a data monitoring quality control process. Future plans UK Biobank is one of the largest prospective cohorts worldwide with extensive data on ophthalmic diseases and conditions. Data collection is an ongoing process and a repeat of the baseline assessment including the questionnaires, measurements and sample collection will be performed in subsets of 25 000 participants every 2-3 years. The depth and breadth of this dataset, coupled with its open-access policy, will create a powerful resource for all researchers to investigate the eye diseases in later life.

Original languageEnglish
Article numbere025077
Pages (from-to)e025077
Number of pages13
JournalBMJ Open
Volume9
Issue number2
Early online date21 Feb 2019
DOIs
Publication statusPublished - 21 Feb 2019

Fingerprint

Eye Diseases
Optical Coherence Tomography
Intraocular Pressure
Health
Multimodal Imaging
Specimen Handling
Training Support
Refractive Errors
Photography
Biomechanical Phenomena
Quality Control
Biochemistry
Visual Acuity
Medical Records
Life Style
Cohort Studies
Research Personnel
Prospective Studies
Brain
Research

Keywords

  • dementia
  • epidemiology
  • medical ophthalmology
  • medical retina

Cite this

UK Biobank Eye and Vision Consortium, Chua, S. Y. L., Thomas, D., Allen, N., Lotery, A., Desai, P., ... Foster, P. J. (2019). Cohort profile: Design and methods in the eye and vision consortium of UK Biobank. BMJ Open, 9(2), e025077. [e025077]. https://doi.org/10.1136/bmjopen-2018-025077
UK Biobank Eye and Vision Consortium ; Chua, Sharon Yu Lin ; Thomas, Dhanes ; Allen, Naomi ; Lotery, Andrew ; Desai, Parul ; Patel, Praveen ; Muthy, Zaynah ; Sudlow, Cathie ; Peto, Tunde ; Khaw, Peng Tee ; Foster, Paul J. / Cohort profile : Design and methods in the eye and vision consortium of UK Biobank. In: BMJ Open. 2019 ; Vol. 9, No. 2. pp. e025077.
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UK Biobank Eye and Vision Consortium, Chua, SYL, Thomas, D, Allen, N, Lotery, A, Desai, P, Patel, P, Muthy, Z, Sudlow, C, Peto, T, Khaw, PT & Foster, PJ 2019, 'Cohort profile: Design and methods in the eye and vision consortium of UK Biobank', BMJ Open, vol. 9, no. 2, e025077, pp. e025077. https://doi.org/10.1136/bmjopen-2018-025077

Cohort profile : Design and methods in the eye and vision consortium of UK Biobank. / UK Biobank Eye and Vision Consortium; Chua, Sharon Yu Lin; Thomas, Dhanes; Allen, Naomi; Lotery, Andrew; Desai, Parul; Patel, Praveen; Muthy, Zaynah; Sudlow, Cathie; Peto, Tunde; Khaw, Peng Tee; Foster, Paul J. (Lead / Corresponding author).

In: BMJ Open, Vol. 9, No. 2, e025077, 21.02.2019, p. e025077.

Research output: Contribution to journalArticle

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AU - Allen, Naomi

AU - Lotery, Andrew

AU - Desai, Parul

AU - Patel, Praveen

AU - Muthy, Zaynah

AU - Sudlow, Cathie

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UK Biobank Eye and Vision Consortium, Chua SYL, Thomas D, Allen N, Lotery A, Desai P et al. Cohort profile: Design and methods in the eye and vision consortium of UK Biobank. BMJ Open. 2019 Feb 21;9(2):e025077. e025077. https://doi.org/10.1136/bmjopen-2018-025077