@article{7774765b5551482c848a6c3f614482aa,
title = "Cohort profile for the STratifying Resilience and Depression Longitudinally (STRADL) study: A depression-focused investigation of Generation Scotland, using detailed clinical, cognitive, and neuroimaging assessments",
abstract = "STratifying Resilience and Depression Longitudinally (STRADL) is a population-based study built on the Generation Scotland: Scottish Family Health Study (GS:SFHS) resource. The aim of STRADL is to subtype major depressive disorder (MDD) on the basis of its aetiology, using detailed clinical, cognitive, and brain imaging assessments. The GS:SFHS provides an important opportunity to study complex gene-environment interactions, incorporating linkage to existing datasets and inclusion of early-life variables for two longitudinal birth cohorts. Specifically, data collection in STRADL included: socio-economic and lifestyle variables; physical measures; questionnaire data that assesses resilience, early-life adversity, personality, psychological health, and lifetime history of mood disorder; laboratory samples; cognitive tests; and brain magnetic resonance imaging. Some of the questionnaire and cognitive data were first assessed at the GS:SFHS baseline assessment between 2006-2011, thus providing longitudinal measures of depression and resilience. Similarly, routine NHS data and early-life variables are linked to STRADL data, further providing opportunities for longitudinal analysis. Recruitment has been completed and we consented and tested 1,188 participants.",
keywords = "Depression, Generation Scotland, Longitudinal, Neuroimaging, Psychological resilience",
author = "Tina Habota and Anca-Larisa Sandu and Waiter, {Gordon D.} and McNeil, {Christopher J.} and Douglas Steele and MacFarlane, {Jennifer A.} and Whalley, {Heather C.} and Ruth Valentine and Dawn Younie and Nichola Crouch and Hawkins, {Emma L.} and Yoriko Hirose and Liana Romaniuk and Keith Milburn and Gordon Buchan and Tessa Coupar and Mairi Stirling and Baljit Jagpal and Beverly McLennan and Lukasz Priba and Harris, {Mathew A.} and Hafferty, {Jonathan D.} and Adams, {Mark J.} and Campbell, {Archie I.} and MacIntrye, {Donald J.} and Alison Pattie and Lee Murphy and Reynolds, {Rebecca M.} and Rebecca Elliot and Penton-Voak, {Ian S.} and Munaf{\`o}, {Marcus R.} and Evans, {Kathryn L.} and Seckl, {Jonathan R.} and Wardlaw, {Joanna M.} and Lawrie, {Stephen M.} and Haley, {Christopher S.} and Porteous, {David J.} and Deary, {Ian J.} and Murray, {Alison D.} and McIntosh, {Andrew M.}",
year = "2021",
month = jul,
day = "16",
doi = "10.12688/wellcomeopenres.15538.2",
language = "English",
volume = "4",
journal = "Wellcome Open Research",
issn = "2398-502X",
publisher = "F1000Research",
}