Cohort profile for the STratifying Resilience and Depression Longitudinally (STRADL) study: A depression-focused investigation of Generation Scotland, using detailed clinical, cognitive, and neuroimaging assessments

Tina Habota; Anca-Larisa Sandu; Gordon D. Waiter; Christopher J. McNeil; Douglas Steele; Jennifer A. MacFarlane; Heather C. Whalley; Ruth Valentine; Dawn Younie; Nichola Crouch; Emma L. Hawkins; Yoriko Hirose; Liana Romaniuk; Keith Milburn; Gordon Buchan; Tessa Coupar; Mairi Stirling; Baljit Jagpal; Beverly McLennan; Lukasz Priba; Matthew A. Harris; Jonathan D. Hafferty; Mark J. Adams; Archie I. Campbell; Donald J. MacIntrye; Alison Pattie; Lee Murphy; Rebecca M. Reynolds; Rebecca Elliot; Ian S. Penton-Voak; Marcus R. Munafò; Kathryn L. Evans; Jonathan R. Seckl; Joanna M. Wardlaw; Stephen M. Lawrie; Christopher S. Haley; David J. Porteous; Ian J. Deary; Alison D. Murray; Andrew M. McIntosh

doi:10.12688/wellcomeopenres.15538.1

Cohort profile for the STratifying Resilience and Depression Longitudinally (STRADL) study: A depression-focused investigation of Generation Scotland, using detailed clinical, cognitive, and neuroimaging assessments

Tina Habota (Lead / Corresponding author), Anca-Larisa Sandu, Gordon D. Waiter, Christopher J. McNeil, Douglas Steele, Jennifer A. MacFarlane, Heather C. Whalley, Ruth Valentine, Dawn Younie, Nichola Crouch, Emma L. Hawkins, Yoriko Hirose, Liana Romaniuk, Keith Milburn, Gordon Buchan, Tessa Coupar, Mairi Stirling, Baljit Jagpal, Beverly McLennan, Lukasz PribaMatthew A. Harris, Jonathan D. Hafferty, Mark J. Adams, Archie I. Campbell, Donald J. MacIntrye, Alison Pattie, Lee Murphy, Rebecca M. Reynolds, Rebecca Elliot, Ian S. Penton-Voak, Marcus R. Munafò, Kathryn L. Evans, Jonathan R. Seckl, Joanna M. Wardlaw, Stephen M. Lawrie, Christopher S. Haley, David J. Porteous, Ian J. Deary, Alison D. Murray, Andrew M. McIntosh

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Abstract

STratifying Resilience and Depression Longitudinally (STRADL) is a population-based study built on the Generation Scotland: Scottish Family Health Study (GS:SFHS) resource. The aim of STRADL is to subtype major depressive disorder (MDD) on the basis of its aetiology, using detailed clinical, cognitive, and brain imaging assessments. The GS:SFHS provides an important opportunity to study complex gene-environment interactions, incorporating linkage to existing datasets and inclusion of early-life variables for two longitudinal birth cohorts. Specifically, data collection in STRADL included: socio-economic and lifestyle variables; physical measures; questionnaire data that assesses resilience, early-life adversity, personality, psychological health, and lifetime history of mood disorder; laboratory samples; cognitive tests; and brain magnetic resonance imaging. Some of the questionnaire and cognitive data were first assessed at the GS:SFHS baseline assessment between 2006-2011, thus providing longitudinal measures of depression and resilience. Similarly, routine NHS data and early-life variables are linked to STRADL data, further providing opportunities for longitudinal analysis. Recruitment has been completed and we consented and tested 1,188 participants.

Original language	English
Article number	185
Number of pages	14
Journal	Wellcome Open Research
Volume	4
DOIs	https://doi.org/10.12688/wellcomeopenres.15538.1
Publication status	Published - 25 Nov 2019

Keywords

Depression
Generation Scotland
Longitudinal
Neuroimaging
Psychological resilience

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Habota, T., Sandu, A-L., Waiter, G. D., McNeil, C. J., Steele, D., MacFarlane, J. A., Whalley, H. C., Valentine, R., Younie, D., Crouch, N., Hawkins, E. L., Hirose, Y., Romaniuk, L., Milburn, K., Buchan, G., Coupar, T., Stirling, M., Jagpal, B., McLennan, B., ... McIntosh, A. M. (2019). Cohort profile for the STratifying Resilience and Depression Longitudinally (STRADL) study: A depression-focused investigation of Generation Scotland, using detailed clinical, cognitive, and neuroimaging assessments. Wellcome Open Research, 4, [185]. https://doi.org/10.12688/wellcomeopenres.15538.1

Habota, Tina ; Sandu, Anca-Larisa ; Waiter, Gordon D. ; McNeil, Christopher J. ; Steele, Douglas ; MacFarlane, Jennifer A. ; Whalley, Heather C. ; Valentine, Ruth ; Younie, Dawn ; Crouch, Nichola ; Hawkins, Emma L. ; Hirose, Yoriko ; Romaniuk, Liana ; Milburn, Keith ; Buchan, Gordon ; Coupar, Tessa ; Stirling, Mairi ; Jagpal, Baljit ; McLennan, Beverly ; Priba, Lukasz ; Harris, Matthew A. ; Hafferty, Jonathan D. ; Adams, Mark J. ; Campbell, Archie I. ; MacIntrye, Donald J. ; Pattie, Alison ; Murphy, Lee ; Reynolds, Rebecca M. ; Elliot, Rebecca ; Penton-Voak, Ian S. ; Munafò, Marcus R. ; Evans, Kathryn L. ; Seckl, Jonathan R. ; Wardlaw, Joanna M. ; Lawrie, Stephen M. ; Haley, Christopher S. ; Porteous, David J. ; Deary, Ian J. ; Murray, Alison D. ; McIntosh, Andrew M. / Cohort profile for the STratifying Resilience and Depression Longitudinally (STRADL) study : A depression-focused investigation of Generation Scotland, using detailed clinical, cognitive, and neuroimaging assessments. In: Wellcome Open Research. 2019 ; Vol. 4.

@article{7774765b5551482c848a6c3f614482aa,

title = "Cohort profile for the STratifying Resilience and Depression Longitudinally (STRADL) study: A depression-focused investigation of Generation Scotland, using detailed clinical, cognitive, and neuroimaging assessments",

abstract = "STratifying Resilience and Depression Longitudinally (STRADL) is a population-based study built on the Generation Scotland: Scottish Family Health Study (GS:SFHS) resource. The aim of STRADL is to subtype major depressive disorder (MDD) on the basis of its aetiology, using detailed clinical, cognitive, and brain imaging assessments. The GS:SFHS provides an important opportunity to study complex gene-environment interactions, incorporating linkage to existing datasets and inclusion of early-life variables for two longitudinal birth cohorts. Specifically, data collection in STRADL included: socio-economic and lifestyle variables; physical measures; questionnaire data that assesses resilience, early-life adversity, personality, psychological health, and lifetime history of mood disorder; laboratory samples; cognitive tests; and brain magnetic resonance imaging. Some of the questionnaire and cognitive data were first assessed at the GS:SFHS baseline assessment between 2006-2011, thus providing longitudinal measures of depression and resilience. Similarly, routine NHS data and early-life variables are linked to STRADL data, further providing opportunities for longitudinal analysis. Recruitment has been completed and we consented and tested 1,188 participants.",

keywords = "Depression, Generation Scotland, Longitudinal, Neuroimaging, Psychological resilience",

author = "Tina Habota and Anca-Larisa Sandu and Waiter, {Gordon D.} and McNeil, {Christopher J.} and Douglas Steele and MacFarlane, {Jennifer A.} and Whalley, {Heather C.} and Ruth Valentine and Dawn Younie and Nichola Crouch and Hawkins, {Emma L.} and Yoriko Hirose and Liana Romaniuk and Keith Milburn and Gordon Buchan and Tessa Coupar and Mairi Stirling and Baljit Jagpal and Beverly McLennan and Lukasz Priba and Harris, {Matthew A.} and Hafferty, {Jonathan D.} and Adams, {Mark J.} and Campbell, {Archie I.} and MacIntrye, {Donald J.} and Alison Pattie and Lee Murphy and Reynolds, {Rebecca M.} and Rebecca Elliot and Penton-Voak, {Ian S.} and Munaf{\`o}, {Marcus R.} and Evans, {Kathryn L.} and Seckl, {Jonathan R.} and Wardlaw, {Joanna M.} and Lawrie, {Stephen M.} and Haley, {Christopher S.} and Porteous, {David J.} and Deary, {Ian J.} and Murray, {Alison D.} and McIntosh, {Andrew M.}",

year = "2019",

month = nov,

day = "25",

doi = "10.12688/wellcomeopenres.15538.1",

language = "English",

volume = "4",

journal = "Wellcome Open Research",

issn = "2398-502X",

publisher = "F1000Research",

}

Habota, T, Sandu, A-L, Waiter, GD, McNeil, CJ, Steele, D, MacFarlane, JA, Whalley, HC, Valentine, R, Younie, D, Crouch, N, Hawkins, EL, Hirose, Y, Romaniuk, L, Milburn, K, Buchan, G, Coupar, T, Stirling, M, Jagpal, B, McLennan, B, Priba, L, Harris, MA, Hafferty, JD, Adams, MJ, Campbell, AI, MacIntrye, DJ, Pattie, A, Murphy, L, Reynolds, RM, Elliot, R, Penton-Voak, IS, Munafò, MR, Evans, KL, Seckl, JR, Wardlaw, JM, Lawrie, SM, Haley, CS, Porteous, DJ, Deary, IJ, Murray, AD & McIntosh, AM 2019, 'Cohort profile for the STratifying Resilience and Depression Longitudinally (STRADL) study: A depression-focused investigation of Generation Scotland, using detailed clinical, cognitive, and neuroimaging assessments', Wellcome Open Research, vol. 4, 185. https://doi.org/10.12688/wellcomeopenres.15538.1

Cohort profile for the STratifying Resilience and Depression Longitudinally (STRADL) study : A depression-focused investigation of Generation Scotland, using detailed clinical, cognitive, and neuroimaging assessments. / Habota, Tina (Lead / Corresponding author); Sandu, Anca-Larisa; Waiter, Gordon D.; McNeil, Christopher J.; Steele, Douglas; MacFarlane, Jennifer A.; Whalley, Heather C.; Valentine, Ruth; Younie, Dawn; Crouch, Nichola; Hawkins, Emma L.; Hirose, Yoriko; Romaniuk, Liana; Milburn, Keith; Buchan, Gordon; Coupar, Tessa; Stirling, Mairi; Jagpal, Baljit; McLennan, Beverly; Priba, Lukasz; Harris, Matthew A.; Hafferty, Jonathan D.; Adams, Mark J.; Campbell, Archie I.; MacIntrye, Donald J.; Pattie, Alison; Murphy, Lee; Reynolds, Rebecca M.; Elliot, Rebecca; Penton-Voak, Ian S.; Munafò, Marcus R.; Evans, Kathryn L.; Seckl, Jonathan R.; Wardlaw, Joanna M.; Lawrie, Stephen M.; Haley, Christopher S.; Porteous, David J.; Deary, Ian J.; Murray, Alison D.; McIntosh, Andrew M.

In: Wellcome Open Research, Vol. 4, 185, 25.11.2019.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Cohort profile for the STratifying Resilience and Depression Longitudinally (STRADL) study

T2 - A depression-focused investigation of Generation Scotland, using detailed clinical, cognitive, and neuroimaging assessments

AU - Habota, Tina

AU - Sandu, Anca-Larisa

AU - Waiter, Gordon D.

AU - McNeil, Christopher J.

AU - Steele, Douglas

AU - MacFarlane, Jennifer A.

AU - Whalley, Heather C.

AU - Valentine, Ruth

AU - Younie, Dawn

AU - Crouch, Nichola

AU - Hawkins, Emma L.

AU - Hirose, Yoriko

AU - Romaniuk, Liana

AU - Milburn, Keith

AU - Buchan, Gordon

AU - Coupar, Tessa

AU - Stirling, Mairi

AU - Jagpal, Baljit

AU - McLennan, Beverly

AU - Priba, Lukasz

AU - Harris, Matthew A.

AU - Hafferty, Jonathan D.

AU - Adams, Mark J.

AU - Campbell, Archie I.

AU - MacIntrye, Donald J.

AU - Pattie, Alison

AU - Murphy, Lee

AU - Reynolds, Rebecca M.

AU - Elliot, Rebecca

AU - Penton-Voak, Ian S.

AU - Munafò, Marcus R.

AU - Evans, Kathryn L.

AU - Seckl, Jonathan R.

AU - Wardlaw, Joanna M.

AU - Lawrie, Stephen M.

AU - Haley, Christopher S.

AU - Porteous, David J.

AU - Deary, Ian J.

AU - Murray, Alison D.

AU - McIntosh, Andrew M.

PY - 2019/11/25

Y1 - 2019/11/25

N2 - STratifying Resilience and Depression Longitudinally (STRADL) is a population-based study built on the Generation Scotland: Scottish Family Health Study (GS:SFHS) resource. The aim of STRADL is to subtype major depressive disorder (MDD) on the basis of its aetiology, using detailed clinical, cognitive, and brain imaging assessments. The GS:SFHS provides an important opportunity to study complex gene-environment interactions, incorporating linkage to existing datasets and inclusion of early-life variables for two longitudinal birth cohorts. Specifically, data collection in STRADL included: socio-economic and lifestyle variables; physical measures; questionnaire data that assesses resilience, early-life adversity, personality, psychological health, and lifetime history of mood disorder; laboratory samples; cognitive tests; and brain magnetic resonance imaging. Some of the questionnaire and cognitive data were first assessed at the GS:SFHS baseline assessment between 2006-2011, thus providing longitudinal measures of depression and resilience. Similarly, routine NHS data and early-life variables are linked to STRADL data, further providing opportunities for longitudinal analysis. Recruitment has been completed and we consented and tested 1,188 participants.

AB - STratifying Resilience and Depression Longitudinally (STRADL) is a population-based study built on the Generation Scotland: Scottish Family Health Study (GS:SFHS) resource. The aim of STRADL is to subtype major depressive disorder (MDD) on the basis of its aetiology, using detailed clinical, cognitive, and brain imaging assessments. The GS:SFHS provides an important opportunity to study complex gene-environment interactions, incorporating linkage to existing datasets and inclusion of early-life variables for two longitudinal birth cohorts. Specifically, data collection in STRADL included: socio-economic and lifestyle variables; physical measures; questionnaire data that assesses resilience, early-life adversity, personality, psychological health, and lifetime history of mood disorder; laboratory samples; cognitive tests; and brain magnetic resonance imaging. Some of the questionnaire and cognitive data were first assessed at the GS:SFHS baseline assessment between 2006-2011, thus providing longitudinal measures of depression and resilience. Similarly, routine NHS data and early-life variables are linked to STRADL data, further providing opportunities for longitudinal analysis. Recruitment has been completed and we consented and tested 1,188 participants.

KW - Depression

KW - Generation Scotland

KW - Longitudinal

KW - Neuroimaging

KW - Psychological resilience

U2 - 10.12688/wellcomeopenres.15538.1

DO - 10.12688/wellcomeopenres.15538.1

M3 - Article

VL - 4

JO - Wellcome Open Research

JF - Wellcome Open Research

SN - 2398-502X

M1 - 185

ER -

Habota T, Sandu A-L, Waiter GD, McNeil CJ, Steele D, MacFarlane JA et al. Cohort profile for the STratifying Resilience and Depression Longitudinally (STRADL) study: A depression-focused investigation of Generation Scotland, using detailed clinical, cognitive, and neuroimaging assessments. Wellcome Open Research. 2019 Nov 25;4. 185. https://doi.org/10.12688/wellcomeopenres.15538.1