Cohort profile for the STratifying Resilience and Depression Longitudinally (STRADL) study: A depression-focused investigation of Generation Scotland, using detailed clinical, cognitive, and neuroimaging assessments

TY - JOUR

T1 - Cohort profile for the STratifying Resilience and Depression Longitudinally (STRADL) study

T2 - A depression-focused investigation of Generation Scotland, using detailed clinical, cognitive, and neuroimaging assessments

AU - Habota, Tina

AU - Sandu, Anca-Larisa

AU - Waiter, Gordon D.

AU - McNeil, Christopher J.

AU - Steele, Douglas

AU - MacFarlane, Jennifer A.

AU - Whalley, Heather C.

AU - Valentine, Ruth

AU - Younie, Dawn

AU - Crouch, Nichola

AU - Hawkins, Emma L.

AU - Hirose, Yoriko

AU - Romaniuk, Liana

AU - Milburn, Keith

AU - Buchan, Gordon

AU - Coupar, Tessa

AU - Stirling, Mairi

AU - Jagpal, Baljit

AU - McLennan, Beverly

AU - Priba, Lukasz

AU - Harris, Mathew A.

AU - Hafferty, Jonathan D.

AU - Adams, Mark J.

AU - Campbell, Archie I.

AU - MacIntrye, Donald J.

AU - Pattie, Alison

AU - Murphy, Lee

AU - Reynolds, Rebecca M.

AU - Elliot, Rebecca

AU - Penton-Voak, Ian S.

AU - Munafò, Marcus R.

AU - Evans, Kathryn L.

AU - Seckl, Jonathan R.

AU - Wardlaw, Joanna M.

AU - Lawrie, Stephen M.

AU - Haley, Christopher S.

AU - Porteous, David J.

AU - Deary, Ian J.

AU - Murray, Alison D.

AU - McIntosh, Andrew M.

PY - 2021/7/16

Y1 - 2021/7/16

N2 - STratifying Resilience and Depression Longitudinally (STRADL) is a population-based study built on the Generation Scotland: Scottish Family Health Study (GS:SFHS) resource. The aim of STRADL is to subtype major depressive disorder (MDD) on the basis of its aetiology, using detailed clinical, cognitive, and brain imaging assessments. The GS:SFHS provides an important opportunity to study complex gene-environment interactions, incorporating linkage to existing datasets and inclusion of early-life variables for two longitudinal birth cohorts. Specifically, data collection in STRADL included: socio-economic and lifestyle variables; physical measures; questionnaire data that assesses resilience, early-life adversity, personality, psychological health, and lifetime history of mood disorder; laboratory samples; cognitive tests; and brain magnetic resonance imaging. Some of the questionnaire and cognitive data were first assessed at the GS:SFHS baseline assessment between 2006-2011, thus providing longitudinal measures of depression and resilience. Similarly, routine NHS data and early-life variables are linked to STRADL data, further providing opportunities for longitudinal analysis. Recruitment has been completed and we consented and tested 1,188 participants.

AB - STratifying Resilience and Depression Longitudinally (STRADL) is a population-based study built on the Generation Scotland: Scottish Family Health Study (GS:SFHS) resource. The aim of STRADL is to subtype major depressive disorder (MDD) on the basis of its aetiology, using detailed clinical, cognitive, and brain imaging assessments. The GS:SFHS provides an important opportunity to study complex gene-environment interactions, incorporating linkage to existing datasets and inclusion of early-life variables for two longitudinal birth cohorts. Specifically, data collection in STRADL included: socio-economic and lifestyle variables; physical measures; questionnaire data that assesses resilience, early-life adversity, personality, psychological health, and lifetime history of mood disorder; laboratory samples; cognitive tests; and brain magnetic resonance imaging. Some of the questionnaire and cognitive data were first assessed at the GS:SFHS baseline assessment between 2006-2011, thus providing longitudinal measures of depression and resilience. Similarly, routine NHS data and early-life variables are linked to STRADL data, further providing opportunities for longitudinal analysis. Recruitment has been completed and we consented and tested 1,188 participants.

KW - Depression

KW - Generation Scotland

KW - Longitudinal

KW - Neuroimaging

KW - Psychological resilience

U2 - 10.12688/wellcomeopenres.15538.2

DO - 10.12688/wellcomeopenres.15538.2

M3 - Article

C2 - 35237729

SN - 2398-502X

VL - 4

JO - Wellcome Open Research

JF - Wellcome Open Research

M1 - 185

ER -