Cohort study of adherence to adjuvant endocrine therapy, breast cancer recurrence and mortality

B. Makubate, P. T. Donnan, J. A. Dewar, A. M. Thompson, C. McCowan (Lead / Corresponding author)

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    142 Citations (Scopus)

    Abstract

    Background: Adjuvant endocrine therapy is recommended for women with oestrogen receptor-positive breast cancer, but many women do not take the medication as directed and they stop treatment before completing the standard 5-year duration.

    Methods: This retrospective cohort study conducted between 1993 and 2008 of all women with incident breast cancer, who are residing in the Tayside region of Scotland, examined adherence to prescribed adjuvant tamoxifen or aromatase inhibitors (AIs). Survival analysis examined the effect of adherence on all-cause mortality, breast cancer death and recurrence, using linked prescribing, cancer registry, clinical cancer audit, hospital discharge and death records.

    Results: A total of 3361 women with breast cancer were followed for a median 4.47 years (interquartile range (IQR) 2.04-8.55). The median overall adherence was 90% (IQR 90-100%), but the annual adherence reduced after a longer period from diagnosis. Low adherence of

    Conclusion: Low adherence to all adjuvant endocrine therapy for women with breast cancer, whether tamoxifen or AI, increases the risk of death.

    Original languageEnglish
    Pages (from-to)1515-1524
    Number of pages10
    JournalBritish Journal of Cancer
    Volume108
    Issue number7
    DOIs
    Publication statusPublished - 16 Apr 2013

    Keywords

    • NONADHERENCE
    • tamoxifen
    • ANASTROZOLE
    • TAMOXIFEN
    • OLDER WOMEN
    • aromatase inhibitors
    • PREDICTORS
    • breast cancer
    • adherence
    • recurrence
    • mortality
    • EARLY DISCONTINUATION
    • MEDICATION

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