Coibamide A Induces mTOR-Independent Autophagy and Cell Death in Human Glioblastoma Cells

Andrew M. Hau; Jeffrey A. Greenwood; Christiane V. Loehr; Jeffrey D. Serrill; Philip J. Proteau; Ian G. Ganley; Kerry L. McPhail; Jane E. Ishmael

doi:10.1371/journal.pone.0065250

Coibamide A Induces mTOR-Independent Autophagy and Cell Death in Human Glioblastoma Cells

Andrew M. Hau, Jeffrey A. Greenwood, Christiane V. Loehr, Jeffrey D. Serrill, Philip J. Proteau, Ian G. Ganley, Kerry L. McPhail, Jane E. Ishmael

Research output: Contribution to journal › Article › peer-review

77 Citations (Scopus)

Abstract

Coibamide A is an N-methyl-stabilized depsipeptide that was isolated from a marine cyanobacterium as part of an International Cooperative Biodiversity Groups (ICBG) program based in Panama. Previous testing of coibamide A in the NCI in vitro 60 cancer cell line panel revealed a potent anti-proliferative response and "COMPARE-negative" profile indicative of a unique mechanism of action. We report that coibamide A is a more potent and efficacious cytotoxin than was previously appreciated, inducing concentration-and time-dependent cytotoxicity (EC50

Original language	English
Article number	e65250
Number of pages	16
Journal	PLoS ONE
Volume	8
Issue number	6
DOIs	https://doi.org/10.1371/journal.pone.0065250
Publication status	Published - 2013

Keywords

APOPTOSIS
INHIBITORS
RADIATION-THERAPY
IN-VITRO
SURVIVAL
MARINE CYANOBACTERIA
NATURAL-PRODUCTS
CANCER
RAPAMYCIN
MALIGNANT GLIOMA-CELLS

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1371/journal.pone.0065250

Cite this

@article{08a8115727fd477d96207eeaf0d67be9,

title = "Coibamide A Induces mTOR-Independent Autophagy and Cell Death in Human Glioblastoma Cells",

abstract = "Coibamide A is an N-methyl-stabilized depsipeptide that was isolated from a marine cyanobacterium as part of an International Cooperative Biodiversity Groups (ICBG) program based in Panama. Previous testing of coibamide A in the NCI in vitro 60 cancer cell line panel revealed a potent anti-proliferative response and {"}COMPARE-negative{"} profile indicative of a unique mechanism of action. We report that coibamide A is a more potent and efficacious cytotoxin than was previously appreciated, inducing concentration-and time-dependent cytotoxicity (EC50",

keywords = "APOPTOSIS, INHIBITORS, RADIATION-THERAPY, IN-VITRO, SURVIVAL, MARINE CYANOBACTERIA, NATURAL-PRODUCTS, CANCER, RAPAMYCIN, MALIGNANT GLIOMA-CELLS",

author = "Hau, {Andrew M.} and Greenwood, {Jeffrey A.} and Loehr, {Christiane V.} and Serrill, {Jeffrey D.} and Proteau, {Philip J.} and Ganley, {Ian G.} and McPhail, {Kerry L.} and Ishmael, {Jane E.}",

year = "2013",

doi = "10.1371/journal.pone.0065250",

language = "English",

volume = "8",

journal = "PLoS ONE",

issn = "1932-6203",

publisher = "Public Library of Science",

number = "6",

}

TY - JOUR

T1 - Coibamide A Induces mTOR-Independent Autophagy and Cell Death in Human Glioblastoma Cells

AU - Hau, Andrew M.

AU - Greenwood, Jeffrey A.

AU - Loehr, Christiane V.

AU - Serrill, Jeffrey D.

AU - Proteau, Philip J.

AU - Ganley, Ian G.

AU - McPhail, Kerry L.

AU - Ishmael, Jane E.

PY - 2013

Y1 - 2013

N2 - Coibamide A is an N-methyl-stabilized depsipeptide that was isolated from a marine cyanobacterium as part of an International Cooperative Biodiversity Groups (ICBG) program based in Panama. Previous testing of coibamide A in the NCI in vitro 60 cancer cell line panel revealed a potent anti-proliferative response and "COMPARE-negative" profile indicative of a unique mechanism of action. We report that coibamide A is a more potent and efficacious cytotoxin than was previously appreciated, inducing concentration-and time-dependent cytotoxicity (EC50

AB - Coibamide A is an N-methyl-stabilized depsipeptide that was isolated from a marine cyanobacterium as part of an International Cooperative Biodiversity Groups (ICBG) program based in Panama. Previous testing of coibamide A in the NCI in vitro 60 cancer cell line panel revealed a potent anti-proliferative response and "COMPARE-negative" profile indicative of a unique mechanism of action. We report that coibamide A is a more potent and efficacious cytotoxin than was previously appreciated, inducing concentration-and time-dependent cytotoxicity (EC50

KW - APOPTOSIS

KW - INHIBITORS

KW - RADIATION-THERAPY

KW - IN-VITRO

KW - SURVIVAL

KW - MARINE CYANOBACTERIA

KW - NATURAL-PRODUCTS

KW - CANCER

KW - RAPAMYCIN

KW - MALIGNANT GLIOMA-CELLS

U2 - 10.1371/journal.pone.0065250

DO - 10.1371/journal.pone.0065250

M3 - Article

SN - 1932-6203

VL - 8

JO - PLoS ONE

JF - PLoS ONE

IS - 6

M1 - e65250

ER -

Coibamide A Induces mTOR-Independent Autophagy and Cell Death in Human Glioblastoma Cells

Abstract

Keywords

UN SDGs

Access to Document

Fingerprint

Cite this