Coibamide A Induces mTOR-Independent Autophagy and Cell Death in Human Glioblastoma Cells

Andrew M. Hau, Jeffrey A. Greenwood, Christiane V. Loehr, Jeffrey D. Serrill, Philip J. Proteau, Ian G. Ganley, Kerry L. McPhail, Jane E. Ishmael

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    49 Citations (Scopus)

    Abstract

    Coibamide A is an N-methyl-stabilized depsipeptide that was isolated from a marine cyanobacterium as part of an International Cooperative Biodiversity Groups (ICBG) program based in Panama. Previous testing of coibamide A in the NCI in vitro 60 cancer cell line panel revealed a potent anti-proliferative response and "COMPARE-negative" profile indicative of a unique mechanism of action. We report that coibamide A is a more potent and efficacious cytotoxin than was previously appreciated, inducing concentration-and time-dependent cytotoxicity (EC50

    Original languageEnglish
    Article number e65250
    Number of pages16
    JournalPLoS ONE
    Volume8
    Issue number6
    DOIs
    Publication statusPublished - 2013

    Keywords

    • APOPTOSIS
    • INHIBITORS
    • RADIATION-THERAPY
    • IN-VITRO
    • SURVIVAL
    • MARINE CYANOBACTERIA
    • NATURAL-PRODUCTS
    • CANCER
    • RAPAMYCIN
    • MALIGNANT GLIOMA-CELLS

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