Colorectal adenomas and diabetes: implications for disease prevention

R. J. C. Steele (Lead / Corresponding author), A. S. Anderson, M. Macleod, A. M. Craigie, S. Caswell, J. Belch, S. Treweek, on behalf of the BeWEL team

    Research output: Contribution to journalArticlepeer-review

    2 Citations (Scopus)


    AIM: The study assessed the baseline type II diabetes mellitus (T2DM) risk status among overweight patients with screen-detected colorectal adenomas and explored the implications of the findings for preventative practice.

    METHOD: Participants, aged 50-74 years (73% male) recruited from four Scottish health boards were assessed for diabetes risk. Participants were categorised as at 'high' diabetes risk if HbA1c ranged between 6.0 to 6.4% or fasting plasma glucose (FPG) ranged from 5.5 to 6.9mmol/l and as potentially undiagnosed T2DM when HbA1c ≥6.5% or FPG ≥7mmol/l. Secondary outcome measures included anthropometric measurements, blood pressure and plasma lipid profile. The tests were repeated at 12 months and diabetes risk categories were re-assessed following intervention procedures.

    RESULTS: Of the 329 participants, a pre-existing diagnosis of T2DM had been made in 47(14.3%). Of the remainder with complete biochemistry results (n=250), 19 (7.6%) were classified as having potentially undiagnosed T2DM and 125 (50.0%) as being at high risk of developing diabetes. More than a quarter of participants in all categories had raised waist circumference, hypertension and plasma lipids indicative of raised cardiovascular risk. At 12 months follow up, diabetes risk category diminished in 20% of the intervention group versus 11% in control [OR 2.26 (95%CI 1.03 - 4.96)].

    CONCLUSION: Results suggest that an diagnosis of adenoma in overweight patients provides a health service opportunity for diabetes assessment, prevention and management in a high risk population at a potentially teachable moment. This article is protected by copyright. All rights reserved.

    Original languageEnglish
    Pages (from-to)589-594
    Number of pages6
    JournalColorectal Disease
    Issue number7
    Early online date12 Jan 2015
    Publication statusPublished - Jul 2015


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