Colorectal adenomas and diabetes

implications for disease prevention

R. J. C. Steele (Lead / Corresponding author), A. S. Anderson, M. Macleod, A. M. Craigie, S. Caswell, J. Belch, S. Treweek, on behalf of the BeWEL team

    Research output: Contribution to journalArticle

    1 Citation (Scopus)

    Abstract

    AIM: The study assessed the baseline type II diabetes mellitus (T2DM) risk status among overweight patients with screen-detected colorectal adenomas and explored the implications of the findings for preventative practice.

    METHOD: Participants, aged 50-74 years (73% male) recruited from four Scottish health boards were assessed for diabetes risk. Participants were categorised as at 'high' diabetes risk if HbA1c ranged between 6.0 to 6.4% or fasting plasma glucose (FPG) ranged from 5.5 to 6.9mmol/l and as potentially undiagnosed T2DM when HbA1c ≥6.5% or FPG ≥7mmol/l. Secondary outcome measures included anthropometric measurements, blood pressure and plasma lipid profile. The tests were repeated at 12 months and diabetes risk categories were re-assessed following intervention procedures.

    RESULTS: Of the 329 participants, a pre-existing diagnosis of T2DM had been made in 47(14.3%). Of the remainder with complete biochemistry results (n=250), 19 (7.6%) were classified as having potentially undiagnosed T2DM and 125 (50.0%) as being at high risk of developing diabetes. More than a quarter of participants in all categories had raised waist circumference, hypertension and plasma lipids indicative of raised cardiovascular risk. At 12 months follow up, diabetes risk category diminished in 20% of the intervention group versus 11% in control [OR 2.26 (95%CI 1.03 - 4.96)].

    CONCLUSION: Results suggest that an diagnosis of adenoma in overweight patients provides a health service opportunity for diabetes assessment, prevention and management in a high risk population at a potentially teachable moment. This article is protected by copyright. All rights reserved.

    Original languageEnglish
    Pages (from-to)589-594
    Number of pages6
    JournalColorectal Disease
    Volume17
    Issue number7
    Early online date12 Jan 2015
    DOIs
    Publication statusPublished - Jul 2015

    Fingerprint

    Adenoma
    Fasting
    Lipids
    Glucose
    Waist Circumference
    Biochemistry
    Type 2 Diabetes Mellitus
    Health Services
    Outcome Assessment (Health Care)
    Blood Pressure
    Hypertension
    Health

    Cite this

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    title = "Colorectal adenomas and diabetes: implications for disease prevention",
    abstract = "AIM: The study assessed the baseline type II diabetes mellitus (T2DM) risk status among overweight patients with screen-detected colorectal adenomas and explored the implications of the findings for preventative practice.METHOD: Participants, aged 50-74 years (73{\%} male) recruited from four Scottish health boards were assessed for diabetes risk. Participants were categorised as at 'high' diabetes risk if HbA1c ranged between 6.0 to 6.4{\%} or fasting plasma glucose (FPG) ranged from 5.5 to 6.9mmol/l and as potentially undiagnosed T2DM when HbA1c ≥6.5{\%} or FPG ≥7mmol/l. Secondary outcome measures included anthropometric measurements, blood pressure and plasma lipid profile. The tests were repeated at 12 months and diabetes risk categories were re-assessed following intervention procedures.RESULTS: Of the 329 participants, a pre-existing diagnosis of T2DM had been made in 47(14.3{\%}). Of the remainder with complete biochemistry results (n=250), 19 (7.6{\%}) were classified as having potentially undiagnosed T2DM and 125 (50.0{\%}) as being at high risk of developing diabetes. More than a quarter of participants in all categories had raised waist circumference, hypertension and plasma lipids indicative of raised cardiovascular risk. At 12 months follow up, diabetes risk category diminished in 20{\%} of the intervention group versus 11{\%} in control [OR 2.26 (95{\%}CI 1.03 - 4.96)].CONCLUSION: Results suggest that an diagnosis of adenoma in overweight patients provides a health service opportunity for diabetes assessment, prevention and management in a high risk population at a potentially teachable moment. This article is protected by copyright. All rights reserved.",
    author = "Steele, {R. J. C.} and Anderson, {A. S.} and M. Macleod and Craigie, {A. M.} and S. Caswell and J. Belch and S. Treweek and {on behalf of the BeWEL team}",
    note = "This article is protected by copyright. All rights reserved.",
    year = "2015",
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    doi = "10.1111/codi.12895",
    language = "English",
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    pages = "589--594",
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    Colorectal adenomas and diabetes : implications for disease prevention. / Steele, R. J. C. (Lead / Corresponding author); Anderson, A. S.; Macleod, M.; Craigie, A. M.; Caswell, S.; Belch, J.; Treweek, S.; on behalf of the BeWEL team.

    In: Colorectal Disease, Vol. 17, No. 7, 07.2015, p. 589-594.

    Research output: Contribution to journalArticle

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    T1 - Colorectal adenomas and diabetes

    T2 - implications for disease prevention

    AU - Steele, R. J. C.

    AU - Anderson, A. S.

    AU - Macleod, M.

    AU - Craigie, A. M.

    AU - Caswell, S.

    AU - Belch, J.

    AU - Treweek, S.

    AU - on behalf of the BeWEL team

    N1 - This article is protected by copyright. All rights reserved.

    PY - 2015/7

    Y1 - 2015/7

    N2 - AIM: The study assessed the baseline type II diabetes mellitus (T2DM) risk status among overweight patients with screen-detected colorectal adenomas and explored the implications of the findings for preventative practice.METHOD: Participants, aged 50-74 years (73% male) recruited from four Scottish health boards were assessed for diabetes risk. Participants were categorised as at 'high' diabetes risk if HbA1c ranged between 6.0 to 6.4% or fasting plasma glucose (FPG) ranged from 5.5 to 6.9mmol/l and as potentially undiagnosed T2DM when HbA1c ≥6.5% or FPG ≥7mmol/l. Secondary outcome measures included anthropometric measurements, blood pressure and plasma lipid profile. The tests were repeated at 12 months and diabetes risk categories were re-assessed following intervention procedures.RESULTS: Of the 329 participants, a pre-existing diagnosis of T2DM had been made in 47(14.3%). Of the remainder with complete biochemistry results (n=250), 19 (7.6%) were classified as having potentially undiagnosed T2DM and 125 (50.0%) as being at high risk of developing diabetes. More than a quarter of participants in all categories had raised waist circumference, hypertension and plasma lipids indicative of raised cardiovascular risk. At 12 months follow up, diabetes risk category diminished in 20% of the intervention group versus 11% in control [OR 2.26 (95%CI 1.03 - 4.96)].CONCLUSION: Results suggest that an diagnosis of adenoma in overweight patients provides a health service opportunity for diabetes assessment, prevention and management in a high risk population at a potentially teachable moment. This article is protected by copyright. All rights reserved.

    AB - AIM: The study assessed the baseline type II diabetes mellitus (T2DM) risk status among overweight patients with screen-detected colorectal adenomas and explored the implications of the findings for preventative practice.METHOD: Participants, aged 50-74 years (73% male) recruited from four Scottish health boards were assessed for diabetes risk. Participants were categorised as at 'high' diabetes risk if HbA1c ranged between 6.0 to 6.4% or fasting plasma glucose (FPG) ranged from 5.5 to 6.9mmol/l and as potentially undiagnosed T2DM when HbA1c ≥6.5% or FPG ≥7mmol/l. Secondary outcome measures included anthropometric measurements, blood pressure and plasma lipid profile. The tests were repeated at 12 months and diabetes risk categories were re-assessed following intervention procedures.RESULTS: Of the 329 participants, a pre-existing diagnosis of T2DM had been made in 47(14.3%). Of the remainder with complete biochemistry results (n=250), 19 (7.6%) were classified as having potentially undiagnosed T2DM and 125 (50.0%) as being at high risk of developing diabetes. More than a quarter of participants in all categories had raised waist circumference, hypertension and plasma lipids indicative of raised cardiovascular risk. At 12 months follow up, diabetes risk category diminished in 20% of the intervention group versus 11% in control [OR 2.26 (95%CI 1.03 - 4.96)].CONCLUSION: Results suggest that an diagnosis of adenoma in overweight patients provides a health service opportunity for diabetes assessment, prevention and management in a high risk population at a potentially teachable moment. This article is protected by copyright. All rights reserved.

    U2 - 10.1111/codi.12895

    DO - 10.1111/codi.12895

    M3 - Article

    VL - 17

    SP - 589

    EP - 594

    JO - Colorectal Disease

    JF - Colorectal Disease

    SN - 1462-8910

    IS - 7

    ER -