Colorectal cancer screening - methodology

F. Jenkinson, R. J. C. Steele

    Research output: Contribution to journalReview article

    24 Citations (Scopus)

    Abstract

    Colorectal cancer (CRC) is a major problem worldwide with the highest incidence being found in developed countries, and is the 3rd most common cancer in Scotland. Patients do not generally have symptoms related to CRC until late in the disease process, so there has been much interest in developing screening programmes to detect CRC early. Most commonly, screening involves the identification of occult blood in stool samples. Alternatives include flexible sigmoidoscopy, colonoscopy, radiological investigation and the identification of DNA mutations or proteins in stool. Candidate markers for mutation identification are K-ras, BRAF, p53 and APC which may be used alone or in combination to identify those with colorectal cancer. (C) 2009 Royal College of Surgeons of Edinburgh (Scottish charity number SC005317) and Royal College of Surgeons in Ireland. Published by Elsevier Ltd. All rights reserved.

    Original languageEnglish
    Pages (from-to)164-171
    Number of pages8
    JournalSurgeon: Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland
    Volume8
    Issue number3
    DOIs
    Publication statusPublished - Jun 2010

    Keywords

    • Colorectal cancer
    • Screening
    • Faecal occult blood
    • DNA mutations
    • Fecal occult blood
    • Randomized controlled trial
    • Base-line findings
    • IMMUNOCHEMICAL TEST
    • CT Colonography
    • Biochip array
    • BRAF gene
    • Stool
    • DNA
    • Mutations

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