Coma blisters in 2 children on anticonvulsant medication.

Anna Basu (Lead / Corresponding author), Sara Brown, Nigel Kirkham, Venkateswaran Ramesh, Suzy Leech, Anita Devlin

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)


Blister formation and eccrine sweat gland necrosis have been recognized to occur in states of impaired consciousness and were first reported following barbiturate intoxication. Their etiology is complex and cannot simply be explained by pressure effects. Now that barbiturates are less frequently used, clinicians are likely to be less aware of the phenomenon of coma blister formation; however, newer drugs have also been associated with the occurrence of coma blisters. We describe 2 new associations of coma blisters and anticonvulsants in children. In the first child, blisters recurred on multiple occasions along with obtundation and edema. Our aims are to alert clinicians to the occurrence of coma blisters in children sedated on anticonvulsant medications and to report the new finding of recurrent coma blisters.

Original languageEnglish
Pages (from-to)1021-1025
Number of pages5
JournalJournal of Child Neurology
Issue number8
Publication statusPublished - 8 Apr 2009

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Clinical Neurology


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