Coma blisters in 2 children on anticonvulsant medication.

Anna Basu (Lead / Corresponding author), Sara Brown, Nigel Kirkham, Venkateswaran Ramesh, Suzy Leech, Anita Devlin

    Research output: Contribution to journalArticlepeer-review

    8 Citations (Scopus)


    Blister formation and eccrine sweat gland necrosis have been recognized to occur in states of impaired consciousness and were first reported following barbiturate intoxication. Their etiology is complex and cannot simply be explained by pressure effects. Now that barbiturates are less frequently used, clinicians are likely to be less aware of the phenomenon of coma blister formation; however, newer drugs have also been associated with the occurrence of coma blisters. We describe 2 new associations of coma blisters and anticonvulsants in children. In the first child, blisters recurred on multiple occasions along with obtundation and edema. Our aims are to alert clinicians to the occurrence of coma blisters in children sedated on anticonvulsant medications and to report the new finding of recurrent coma blisters.

    Original languageEnglish
    Pages (from-to)1021-1025
    Number of pages5
    JournalJournal of Child Neurology
    Issue number8
    Publication statusPublished - 8 Apr 2009

    ASJC Scopus subject areas

    • Pediatrics, Perinatology, and Child Health
    • Clinical Neurology


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