Combination of Polymer Technology and Carbon Nanotube Array for the Development of an Effective Drug Delivery System at Cellular Level

Cristina Riggio; Gianni Ciofani; Vittoria Raffa; Alfred Cuschieri; Silvestro Micera

doi:10.1007/s11671-009-9291-0

Combination of Polymer Technology and Carbon Nanotube Array for the Development of an Effective Drug Delivery System at Cellular Level

Cristina Riggio, Gianni Ciofani, Vittoria Raffa, Alfred Cuschieri, Silvestro Micera

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

In this article, a carbon nanotube (CNT) array-based system combined with a polymer thin film is proposed as an effective drug release device directly at cellular level. The polymeric film embedded in the CNT array is described and characterized in terms of release kinetics, while in vitro assays on PC12 cell line have been performed in order to assess the efficiency and functionality of the entrapped agent (neural growth factor, NGF). PC12 cell differentiation, following incubation on the CNT array embedding the alginate delivery film, demonstrated the effectiveness of the proposed solution. The achieved results indicate that polymeric technology could be efficiently embedded in CNT array acting as drug delivery system at cellular level. The implication of this study opens several perspectives in particular in the field of neurointerfaces, combining several functions into a single platform.

Original language	English
Pages (from-to)	668-673
Number of pages	6
Journal	Nanoscale Research Letters
Volume	4
Issue number	7
DOIs	https://doi.org/10.1007/s11671-009-9291-0
Publication status	Published - Jul 2009

Keywords

Vertically aligned carbon nanotubes
Drug delivery
Alginate
NGF
PC12 cells
NEURAL INTERFACES
NERVOUS-SYSTEM
ALGINATE BEADS
RELEASE
NANOPARTICLES
MICROSPHERES
ELECTRODES

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10.1007/s11671-009-9291-0

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title = "Combination of Polymer Technology and Carbon Nanotube Array for the Development of an Effective Drug Delivery System at Cellular Level",

abstract = "In this article, a carbon nanotube (CNT) array-based system combined with a polymer thin film is proposed as an effective drug release device directly at cellular level. The polymeric film embedded in the CNT array is described and characterized in terms of release kinetics, while in vitro assays on PC12 cell line have been performed in order to assess the efficiency and functionality of the entrapped agent (neural growth factor, NGF). PC12 cell differentiation, following incubation on the CNT array embedding the alginate delivery film, demonstrated the effectiveness of the proposed solution. The achieved results indicate that polymeric technology could be efficiently embedded in CNT array acting as drug delivery system at cellular level. The implication of this study opens several perspectives in particular in the field of neurointerfaces, combining several functions into a single platform.",

keywords = "Vertically aligned carbon nanotubes, Drug delivery, Alginate, NGF, PC12 cells, NEURAL INTERFACES, NERVOUS-SYSTEM, ALGINATE BEADS, RELEASE, NANOPARTICLES, MICROSPHERES, ELECTRODES",

author = "Cristina Riggio and Gianni Ciofani and Vittoria Raffa and Alfred Cuschieri and Silvestro Micera",

year = "2009",

month = jul,

doi = "10.1007/s11671-009-9291-0",

language = "English",

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journal = "Nanoscale Research Letters",

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T1 - Combination of Polymer Technology and Carbon Nanotube Array for the Development of an Effective Drug Delivery System at Cellular Level

AU - Riggio, Cristina

AU - Ciofani, Gianni

AU - Raffa, Vittoria

AU - Cuschieri, Alfred

AU - Micera, Silvestro

PY - 2009/7

Y1 - 2009/7

N2 - In this article, a carbon nanotube (CNT) array-based system combined with a polymer thin film is proposed as an effective drug release device directly at cellular level. The polymeric film embedded in the CNT array is described and characterized in terms of release kinetics, while in vitro assays on PC12 cell line have been performed in order to assess the efficiency and functionality of the entrapped agent (neural growth factor, NGF). PC12 cell differentiation, following incubation on the CNT array embedding the alginate delivery film, demonstrated the effectiveness of the proposed solution. The achieved results indicate that polymeric technology could be efficiently embedded in CNT array acting as drug delivery system at cellular level. The implication of this study opens several perspectives in particular in the field of neurointerfaces, combining several functions into a single platform.

AB - In this article, a carbon nanotube (CNT) array-based system combined with a polymer thin film is proposed as an effective drug release device directly at cellular level. The polymeric film embedded in the CNT array is described and characterized in terms of release kinetics, while in vitro assays on PC12 cell line have been performed in order to assess the efficiency and functionality of the entrapped agent (neural growth factor, NGF). PC12 cell differentiation, following incubation on the CNT array embedding the alginate delivery film, demonstrated the effectiveness of the proposed solution. The achieved results indicate that polymeric technology could be efficiently embedded in CNT array acting as drug delivery system at cellular level. The implication of this study opens several perspectives in particular in the field of neurointerfaces, combining several functions into a single platform.

KW - Vertically aligned carbon nanotubes

KW - Drug delivery

KW - Alginate

KW - NGF

KW - PC12 cells

KW - NEURAL INTERFACES

KW - NERVOUS-SYSTEM

KW - ALGINATE BEADS

KW - RELEASE

KW - NANOPARTICLES

KW - MICROSPHERES

KW - ELECTRODES

U2 - 10.1007/s11671-009-9291-0

DO - 10.1007/s11671-009-9291-0

M3 - Article

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SN - 1931-7573

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EP - 673

JO - Nanoscale Research Letters

JF - Nanoscale Research Letters

IS - 7

ER -

Combination of Polymer Technology and Carbon Nanotube Array for the Development of an Effective Drug Delivery System at Cellular Level

Abstract

Keywords

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