Commentary: We've only just begun: unravelling the underlying genetics of neurodevelopmental disorders - a commentary on Kiser et al. (2015)

David Coghill

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    2 Citations (Scopus)

    Abstract

    Kiser and colleagues (this issue) have presented us with a comprehensive and bold review that describes current understanding of the genetic influences that underpin three of the most important neurodevelopmental disorders: attention deficit hyperactivity disorder (ADHD), autism spectrum disorder (ASD) and intellectual disability (ID), and explores several new avenues of thinking that are opening up based on this knowledge. Based on phenotypic overlap, comorbidity and a sharing of genetic and environmental risks they propose that ADHD, ASD and ID together form part of a continuum. The idea that disorders we have traditionally seen as being separate are in fact inter-related is, of course, not an entirely new one and indeed has similarly been proposed for the developmental disorders by Gillberg and in a more general way as a part of the NIMH Research Domain Criteria (RDoC) project. Where this review differs is in the authors' attempts to look at several possible mechanisms for these.

    Original languageEnglish
    Pages (from-to)296-298
    Number of pages3
    JournalJournal of Child Psychology and Psychiatry
    Volume56
    Issue number3
    Early online date25 Feb 2015
    DOIs
    Publication statusPublished - Mar 2015

    Keywords

    • de novo mutations
    • genetic variations
    • genomics
    • neurobiology
    • Neurodevelopmental disorders
    • shared cognitive deficits

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