Common pitfalls and recommendations for using machine learning to detect and prognosticate for COVID-19 using chest radiographs and CT scans

Michael Roberts (Lead / Corresponding author), Derek Driggs, Matthew Thorpe, Julian Gilbey, Michael Yeung, Stephan Ursprung, Angelica I. Aviles-Rivero, Christian Etmann, Cathal McCague, Lucian Beer, Jonathan R. Weir-McCall, Zhongzhao Teng, Effrossyni Gkrania-Klotsas, AIX-COVNET, James H. F. Rudd, Evis Sala, Carola-Bibiane Schönlieb

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)
4 Downloads (Pure)

Abstract

Machine learning methods offer great promise for fast and accurate detection and prognostication of coronavirus disease 2019 (COVID-19) from standard-of-care chest radiographs (CXR) and chest computed tomography (CT) images. Many articles have been published in 2020 describing new machine learning-based models for both of these tasks, but it is unclear which are of potential clinical utility. In this systematic review, we consider all published papers and preprints, for the period from 1 January 2020 to 3 October 2020, which describe new machine learning models for the diagnosis or prognosis of COVID-19 from CXR or CT images. All manuscripts uploaded to bioRxiv, medRxiv and arXiv along with all entries in EMBASE and MEDLINE in this timeframe are considered. Our search identified 2,212 studies, of which 415 were included after initial screening and, after quality screening, 62 studies were included in this systematic review. Our review finds that none of the models identified are of potential clinical use due to methodological flaws and/or underlying biases. This is a major weakness, given the urgency with which validated COVID-19 models are needed. To address this, we give many recommendations which, if followed, will solve these issues and lead to higher-quality model development and well-documented manuscripts.

Original languageEnglish
Pages (from-to)199-217
Number of pages19
JournalNature Machine Intelligence
Volume3
Issue number3
Early online date15 Mar 2021
DOIs
Publication statusPublished - Mar 2021

Keywords

  • Computational science
  • Diagnostic markers
  • Prognostic markers
  • SARS-Cov-2

Fingerprint Dive into the research topics of 'Common pitfalls and recommendations for using machine learning to detect and prognosticate for COVID-19 using chest radiographs and CT scans'. Together they form a unique fingerprint.

Cite this