Common variants associated with plasma triglycerides and risk for coronary artery disease

Ron Do; Cristen J. Willer; Ellen M. Schmidt; Sebanti Sengupta; Chi Gao; Gina M. Peloso; Stefan Gustafsson; Stavroula Kanoni; Andrea Ganna; Jin Chen; Martin L. Buchkovich; Samia Mora; Jacques S. Beckmann; Jennifer L. Bragg-Gresham; Hsing-Yi Chang; Ayşe Demirkan; Heleen M. Den Hertog; Louise A. Donnelly; Georg B. Ehret; Tõnu Esko; Mary F. Feitosa; Teresa Ferreira; Krista Fischer; Pierre Fontanillas; Ross M. Fraser; Daniel F. Freitag; Deepti Gurdasani; Kauko Heikkilä; Elina Hyppönen; Aaron Isaacs; Anne U. Jackson; Asa Johansson; Toby Johnson; Marika Kaakinen; Johannes Kettunen; Marcus E. Kleber; Xiaohui Li; Jian'an Luan; Leo-Pekka Lyytikäinen; Patrik K. E. Magnusson; Massimo Mangino; Evelin Mihailov; May E. Montasser; Martina Müller-Nurasyid; Ilja M. Nolte; Jeffrey R. O'Connell; Cameron D. Palmer; Markus Perola; Ann-Kristin Petersen; Serena Sanna; Richa Saxena; Susan K. Service; Sonia Shah; Dmitry Shungin; Carlo Sidore; Ci Song; Rona J. Strawbridge; Ida Surakka; Toshiko Tanaka; Tanya M. Teslovich; Gudmar Thorleifsson; Evita G. Van den Herik; Benjamin F. Voight; Kelly A. Volcik; Lindsay L. Waite; Andrew Wong; Ying Wu; Weihua Zhang; Devin Absher; Gershim Asiki; Inês Barroso; Latonya F. Been; Jennifer L. Bolton; Lori L. Bonnycastle; Paolo Brambilla; Mary S. Burnett; Giancarlo Cesana; Maria Dimitriou; Alex S. F.  Doney; Angela Döring; Paul Elliott; Stephen E. Epstein; Gudmundur Ingi Eyjolfsson; Bruna Gigante; Mark O. Goodarzi; Harald Grallert; Martha L. Gravito; Christopher J. Groves; Göran Hallmans; Anna-Liisa Hartikainen; Caroline Hayward; Dena Hernandez; Andrew A. Hicks; Hilma Holm; Yi-Jen Hung; Thomas Illig; Michelle R. Jones; Pontiano Kaleebu; John J. P. Kastelein; Kay-Tee Khaw; Eric Kim; Norman Klopp; Pirjo Komulainen; Meena Kumari; Claudia Langenberg; Terho Lehtimäki; Shih-Yi Lin; Jaana Lindström; Ruth J. F. Loos; François Mach; Wendy L. McArdle; Christa Meisinger; Braxton D. Mitchell; Gabrielle Müller; Ramaiah Nagaraja; Narisu Narisu; Tuomo V. M. Nieminen; Rebecca N. Nsubuga; Isleifur Olafsson; Ken K. Ong; Aarno Palotie; Theodore Papamarkou; Cristina Pomilla; Anneli Pouta; Daniel J. Rader; Muredach P. Reilly; Paul M. Ridker; Fernando Rivadeneira; Igor Rudan; Aimo Ruokonen; Nilesh Samani; Hubert Scharnagl; Janet Seeley; Kaisa Silander; Alena Stančáková; Kathleen Stirrups; Amy J. Swift; Laurence Tiret; Andre G. Uitterlinden; L. Joost van Pelt; Sailaja Vedantam; Nicholas Wainwright; Cisca Wijmenga; Sarah H. Wild; Gonneke Willemsen; Tom Wilsgaard; James F. Wilson; Elizabeth H. Young; Jing Hua Zhao; Linda S. Adair; Dominique Arveiler; Themistocles L. Assimes; Stefania Bandinelli; Franklyn Bennett; Murielle Bochud; Bernhard O. Boehm; Dorret I. Boomsma; Ingrid B. Borecki; Stefan R. Bornstein; Pascal Bovet; Michel Burnier; Harry Campbell; Aravinda Chakravarti; John C. Chambers; Yii-Der Ida Chen; Francis S. Collins; Richard S. Cooper; John Danesh; George Dedoussis; Ulf de Faire; Alan B. Feranil; Jean Ferrières; Luigi Ferrucci; Nelson B. Freimer; Christian Gieger; Leif C. Groop; Vilmundur Gudnason; Ulf Gyllensten; Anders Hamsten; Tamara B. Harris; Aroon Hingorani; Joel N. Hirschhorn; Albert Hofman; G. Kees Hovingh; Chao Agnes Hsiung; Steve E. Humphries; Steven C. Hunt; Kristian Hveem; Carlos Iribarren; Marjo-Riitta Järvelin; Antti Jula; Mika Kähönen; Jaakko Kaprio; Antero Kesäniemi; Mika Kivimaki; Jaspal S. Kooner; Peter J. Koudstaal; Ronald M. Krauss; Diana Kuh; Johanna Kuusisto; Kirsten O. Kyvik; Markku Laakso; Timo A. Lakka; Lars Lind; Cecilia M. Lindgren; Nicholas G. Martin; Winfried März; Mark I. McCarthy; Colin A. McKenzie; Pierre Meneton; Andres Metspalu; Leena Moilanen; Andrew D. Morris; Patricia B. Munroe; Inger Njølstad; Nancy L. Pedersen; Chris Power; Peter P. Pramstaller; Jackie F. Price; Bruce M. Psaty; Thomas Quertermous; Rainer Rauramaa; Danish Saleheen; Veikko Salomaa; Dharambir K. Sanghera; Jouko Saramies; Peter E. H. Schwarz; Wayne H.-H. Sheu; Alan R. Shuldiner; Agneta Siegbahn; Tim D. Spector; Kari Stefansson; David P. Strachan; Bamidele O. Tayo; Elena Tremoli; Jaakko Tuomilehto; Matti Uusitupa; Cornelia M. van Duijn; Peter Vollenweider; Lars Wallentin; Nicholas J. Wareham; John B. Whitfield; Bruce H. R. Wolffenbuttel; David Altshuler; Jose M. Ordovas; Eric Boerwinkle; Colin N. A. Palmer; Unnur Thorsteinsdottir; Daniel I. Chasman; Jerome I. Rotter; Paul W. Franks; Samuli Ripatti; L. Adrienne Cupples; Manjinder S. Sandhu; Stephen S. Rich; Michael Boehnke; Panos Deloukas; Karen L. Mohlke; Erik Ingelsson; Goncalo R. Abecasis; Mark J. Daly; Benjamin M. Neale; Sekar Kathiresan

doi:10.1038/ng.2795

Common variants associated with plasma triglycerides and risk for coronary artery disease

Ron Do, Cristen J. Willer, Ellen M. Schmidt, Sebanti Sengupta, Chi Gao, Gina M. Peloso, Stefan Gustafsson, Stavroula Kanoni, Andrea Ganna, Jin Chen, Martin L. Buchkovich, Samia Mora, Jacques S. Beckmann, Jennifer L. Bragg-Gresham, Hsing-Yi Chang, Ayşe Demirkan, Heleen M. Den Hertog, Louise A. Donnelly, Georg B. Ehret, Tõnu EskoMary F. Feitosa, Teresa Ferreira, Krista Fischer, Pierre Fontanillas, Ross M. Fraser, Daniel F. Freitag, Deepti Gurdasani, Kauko Heikkilä, Elina Hyppönen, Aaron Isaacs, Anne U. Jackson, Asa Johansson, Toby Johnson, Marika Kaakinen, Johannes Kettunen, Marcus E. Kleber, Xiaohui Li, Jian'an Luan, Leo-Pekka Lyytikäinen, Patrik K. E. Magnusson, Massimo Mangino, Evelin Mihailov, May E. Montasser, Martina Müller-Nurasyid, Ilja M. Nolte, Jeffrey R. O'Connell, Cameron D. Palmer, Markus Perola, Ann-Kristin Petersen, Serena Sanna, Richa Saxena, Susan K. Service, Sonia Shah, Dmitry Shungin, Carlo Sidore, Ci Song, Rona J. Strawbridge, Ida Surakka, Toshiko Tanaka, Tanya M. Teslovich, Gudmar Thorleifsson, Evita G. Van den Herik, Benjamin F. Voight, Kelly A. Volcik, Lindsay L. Waite, Andrew Wong, Ying Wu, Weihua Zhang, Devin Absher, Gershim Asiki, Inês Barroso, Latonya F. Been, Jennifer L. Bolton, Lori L. Bonnycastle, Paolo Brambilla, Mary S. Burnett, Giancarlo Cesana, Maria Dimitriou, Alex S. F. Doney, Angela Döring, Paul Elliott, Stephen E. Epstein, Gudmundur Ingi Eyjolfsson, Bruna Gigante, Mark O. Goodarzi, Harald Grallert, Martha L. Gravito, Christopher J. Groves, Göran Hallmans, Anna-Liisa Hartikainen, Caroline Hayward, Dena Hernandez, Andrew A. Hicks, Hilma Holm, Yi-Jen Hung, Thomas Illig, Michelle R. Jones, Pontiano Kaleebu, John J. P. Kastelein, Kay-Tee Khaw, Eric Kim, Norman Klopp, Pirjo Komulainen, Meena Kumari, Claudia Langenberg, Terho Lehtimäki, Shih-Yi Lin, Jaana Lindström, Ruth J. F. Loos, François Mach, Wendy L. McArdle, Christa Meisinger, Braxton D. Mitchell, Gabrielle Müller, Ramaiah Nagaraja, Narisu Narisu, Tuomo V. M. Nieminen, Rebecca N. Nsubuga, Isleifur Olafsson, Ken K. Ong, Aarno Palotie, Theodore Papamarkou, Cristina Pomilla, Anneli Pouta, Daniel J. Rader, Muredach P. Reilly, Paul M. Ridker, Fernando Rivadeneira, Igor Rudan, Aimo Ruokonen, Nilesh Samani, Hubert Scharnagl, Janet Seeley, Kaisa Silander, Alena Stančáková, Kathleen Stirrups, Amy J. Swift, Laurence Tiret, Andre G. Uitterlinden, L. Joost van Pelt, Sailaja Vedantam, Nicholas Wainwright, Cisca Wijmenga, Sarah H. Wild, Gonneke Willemsen, Tom Wilsgaard, James F. Wilson, Elizabeth H. Young, Jing Hua Zhao, Linda S. Adair, Dominique Arveiler, Themistocles L. Assimes, Stefania Bandinelli, Franklyn Bennett, Murielle Bochud, Bernhard O. Boehm, Dorret I. Boomsma, Ingrid B. Borecki, Stefan R. Bornstein, Pascal Bovet, Michel Burnier, Harry Campbell, Aravinda Chakravarti, John C. Chambers, Yii-Der Ida Chen, Francis S. Collins, Richard S. Cooper, John Danesh, George Dedoussis, Ulf de Faire, Alan B. Feranil, Jean Ferrières, Luigi Ferrucci, Nelson B. Freimer, Christian Gieger, Leif C. Groop, Vilmundur Gudnason, Ulf Gyllensten, Anders Hamsten, Tamara B. Harris, Aroon Hingorani, Joel N. Hirschhorn, Albert Hofman, G. Kees Hovingh, Chao Agnes Hsiung, Steve E. Humphries, Steven C. Hunt, Kristian Hveem, Carlos Iribarren, Marjo-Riitta Järvelin, Antti Jula, Mika Kähönen, Jaakko Kaprio, Antero Kesäniemi, Mika Kivimaki, Jaspal S. Kooner, Peter J. Koudstaal, Ronald M. Krauss, Diana Kuh, Johanna Kuusisto, Kirsten O. Kyvik, Markku Laakso, Timo A. Lakka, Lars Lind, Cecilia M. Lindgren, Nicholas G. Martin, Winfried März, Mark I. McCarthy, Colin A. McKenzie, Pierre Meneton, Andres Metspalu, Leena Moilanen, Andrew D. Morris, Patricia B. Munroe, Inger Njølstad, Nancy L. Pedersen, Chris Power, Peter P. Pramstaller, Jackie F. Price, Bruce M. Psaty, Thomas Quertermous, Rainer Rauramaa, Danish Saleheen, Veikko Salomaa, Dharambir K. Sanghera, Jouko Saramies, Peter E. H. Schwarz, Wayne H.-H. Sheu, Alan R. Shuldiner, Agneta Siegbahn, Tim D. Spector, Kari Stefansson, David P. Strachan, Bamidele O. Tayo, Elena Tremoli, Jaakko Tuomilehto, Matti Uusitupa, Cornelia M. van Duijn, Peter Vollenweider, Lars Wallentin, Nicholas J. Wareham, John B. Whitfield, Bruce H. R. Wolffenbuttel, David Altshuler, Jose M. Ordovas, Eric Boerwinkle, Colin N. A. Palmer, Unnur Thorsteinsdottir, Daniel I. Chasman, Jerome I. Rotter, Paul W. Franks, Samuli Ripatti, L. Adrienne Cupples, Manjinder S. Sandhu, Stephen S. Rich, Michael Boehnke, Panos Deloukas, Karen L. Mohlke, Erik Ingelsson, Goncalo R. Abecasis, Mark J. Daly, Benjamin M. Neale, Sekar Kathiresan

Research output: Contribution to journal › Letter › peer-review

691 Citations (Scopus)

Abstract

Triglycerides are transported in plasma by specific triglyceride-rich lipoproteins; in epidemiological studies, increased triglyceride levels correlate with higher risk for coronary artery disease (CAD). However, it is unclear whether this association reflects causal processes. We used 185 common variants recently mapped for plasma lipids (P < 5 × 10 -8 for each) to examine the role of triglycerides in risk for CAD. First, we highlight loci associated with both low-density lipoprotein cholesterol (LDL-C) and triglyceride levels, and we show that the direction and magnitude of the associations with both traits are factors in determining CAD risk. Second, we consider loci with only a strong association with triglycerides and show that these loci are also associated with CAD. Finally, in a model accounting for effects on LDL-C and/or high-density lipoprotein cholesterol (HDL-C) levels, the strength of a polymorphism's effect on triglyceride levels is correlated with the magnitude of its effect on CAD risk. These results suggest that triglyceride-rich lipoproteins causally influence risk for CAD

Original language	English
Pages (from-to)	1345-1352
Number of pages	8
Journal	Nature Genetics
Volume	45
Issue number	11
DOIs	https://doi.org/10.1038/ng.2795
Publication status	Published - 2013

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10.1038/ng.2795

Cite this

Do, R., Willer, C. J., Schmidt, E. M., Sengupta, S., Gao, C., Peloso, G. M., Gustafsson, S., Kanoni, S., Ganna, A., Chen, J., Buchkovich, M. L., Mora, S., Beckmann, J. S., Bragg-Gresham, J. L., Chang, H.-Y., Demirkan, A., Den Hertog, H. M., Donnelly, L. A., Ehret, G. B., ... Kathiresan, S. (2013). Common variants associated with plasma triglycerides and risk for coronary artery disease. Nature Genetics, 45(11), 1345-1352. https://doi.org/10.1038/ng.2795

@article{e6c1340370ca4562abc1993b8361137f,

title = "Common variants associated with plasma triglycerides and risk for coronary artery disease",

abstract = "Triglycerides are transported in plasma by specific triglyceride-rich lipoproteins; in epidemiological studies, increased triglyceride levels correlate with higher risk for coronary artery disease (CAD). However, it is unclear whether this association reflects causal processes. We used 185 common variants recently mapped for plasma lipids (P < 5 × 10 -8 for each) to examine the role of triglycerides in risk for CAD. First, we highlight loci associated with both low-density lipoprotein cholesterol (LDL-C) and triglyceride levels, and we show that the direction and magnitude of the associations with both traits are factors in determining CAD risk. Second, we consider loci with only a strong association with triglycerides and show that these loci are also associated with CAD. Finally, in a model accounting for effects on LDL-C and/or high-density lipoprotein cholesterol (HDL-C) levels, the strength of a polymorphism's effect on triglyceride levels is correlated with the magnitude of its effect on CAD risk. These results suggest that triglyceride-rich lipoproteins causally influence risk for CAD",

author = "Ron Do and Willer, {Cristen J.} and Schmidt, {Ellen M.} and Sebanti Sengupta and Chi Gao and Peloso, {Gina M.} and Stefan Gustafsson and Stavroula Kanoni and Andrea Ganna and Jin Chen and Buchkovich, {Martin L.} and Samia Mora and Beckmann, {Jacques S.} and Bragg-Gresham, {Jennifer L.} and Hsing-Yi Chang and Ay{\c s}e Demirkan and {Den Hertog}, {Heleen M.} and Donnelly, {Louise A.} and Ehret, {Georg B.} and T{\~o}nu Esko and Feitosa, {Mary F.} and Teresa Ferreira and Krista Fischer and Pierre Fontanillas and Fraser, {Ross M.} and Freitag, {Daniel F.} and Deepti Gurdasani and Kauko Heikkil{\"a} and Elina Hypp{\"o}nen and Aaron Isaacs and Jackson, {Anne U.} and Asa Johansson and Toby Johnson and Marika Kaakinen and Johannes Kettunen and Kleber, {Marcus E.} and Xiaohui Li and Jian'an Luan and Leo-Pekka Lyytik{\"a}inen and Magnusson, {Patrik K. E.} and Massimo Mangino and Evelin Mihailov and Montasser, {May E.} and Martina M{\"u}ller-Nurasyid and Nolte, {Ilja M.} and O'Connell, {Jeffrey R.} and Palmer, {Cameron D.} and Markus Perola and Ann-Kristin Petersen and Serena Sanna and Richa Saxena and Service, {Susan K.} and Sonia Shah and Dmitry Shungin and Carlo Sidore and Ci Song and Strawbridge, {Rona J.} and Ida Surakka and Toshiko Tanaka and Teslovich, {Tanya M.} and Gudmar Thorleifsson and {Van den Herik}, {Evita G.} and Voight, {Benjamin F.} and Volcik, {Kelly A.} and Waite, {Lindsay L.} and Andrew Wong and Ying Wu and Weihua Zhang and Devin Absher and Gershim Asiki and In{\^e}s Barroso and Been, {Latonya F.} and Bolton, {Jennifer L.} and Bonnycastle, {Lori L.} and Paolo Brambilla and Burnett, {Mary S.} and Giancarlo Cesana and Maria Dimitriou and Doney, {Alex S. F.} and Angela D{\"o}ring and Paul Elliott and Epstein, {Stephen E.} and Eyjolfsson, {Gudmundur Ingi} and Bruna Gigante and Goodarzi, {Mark O.} and Harald Grallert and Gravito, {Martha L.} and Groves, {Christopher J.} and G{\"o}ran Hallmans and Anna-Liisa Hartikainen and Caroline Hayward and Dena Hernandez and Hicks, {Andrew A.} and Hilma Holm and Yi-Jen Hung and Thomas Illig and Jones, {Michelle R.} and Pontiano Kaleebu and Kastelein, {John J. P.} and Kay-Tee Khaw and Eric Kim and Norman Klopp and Pirjo Komulainen and Meena Kumari and Claudia Langenberg and Terho Lehtim{\"a}ki and Shih-Yi Lin and Jaana Lindstr{\"o}m and Loos, {Ruth J. F.} and Fran{\c c}ois Mach and McArdle, {Wendy L.} and Christa Meisinger and Mitchell, {Braxton D.} and Gabrielle M{\"u}ller and Ramaiah Nagaraja and Narisu Narisu and Nieminen, {Tuomo V. M.} and Nsubuga, {Rebecca N.} and Isleifur Olafsson and Ong, {Ken K.} and Aarno Palotie and Theodore Papamarkou and Cristina Pomilla and Anneli Pouta and Rader, {Daniel J.} and Reilly, {Muredach P.} and Ridker, {Paul M.} and Fernando Rivadeneira and Igor Rudan and Aimo Ruokonen and Nilesh Samani and Hubert Scharnagl and Janet Seeley and Kaisa Silander and Alena Stan{\v c}{\'a}kov{\'a} and Kathleen Stirrups and Swift, {Amy J.} and Laurence Tiret and Uitterlinden, {Andre G.} and {van Pelt}, {L. Joost} and Sailaja Vedantam and Nicholas Wainwright and Cisca Wijmenga and Wild, {Sarah H.} and Gonneke Willemsen and Tom Wilsgaard and Wilson, {James F.} and Young, {Elizabeth H.} and Zhao, {Jing Hua} and Adair, {Linda S.} and Dominique Arveiler and Assimes, {Themistocles L.} and Stefania Bandinelli and Franklyn Bennett and Murielle Bochud and Boehm, {Bernhard O.} and Boomsma, {Dorret I.} and Borecki, {Ingrid B.} and Bornstein, {Stefan R.} and Pascal Bovet and Michel Burnier and Harry Campbell and Aravinda Chakravarti and Chambers, {John C.} and Chen, {Yii-Der Ida} and Collins, {Francis S.} and Cooper, {Richard S.} and John Danesh and George Dedoussis and {de Faire}, Ulf and Feranil, {Alan B.} and Jean Ferri{\`e}res and Luigi Ferrucci and Freimer, {Nelson B.} and Christian Gieger and Groop, {Leif C.} and Vilmundur Gudnason and Ulf Gyllensten and Anders Hamsten and Harris, {Tamara B.} and Aroon Hingorani and Hirschhorn, {Joel N.} and Albert Hofman and Hovingh, {G. Kees} and Hsiung, {Chao Agnes} and Humphries, {Steve E.} and Hunt, {Steven C.} and Kristian Hveem and Carlos Iribarren and Marjo-Riitta J{\"a}rvelin and Antti Jula and Mika K{\"a}h{\"o}nen and Jaakko Kaprio and Antero Kes{\"a}niemi and Mika Kivimaki and Kooner, {Jaspal S.} and Koudstaal, {Peter J.} and Krauss, {Ronald M.} and Diana Kuh and Johanna Kuusisto and Kyvik, {Kirsten O.} and Markku Laakso and Lakka, {Timo A.} and Lars Lind and Lindgren, {Cecilia M.} and Martin, {Nicholas G.} and Winfried M{\"a}rz and McCarthy, {Mark I.} and McKenzie, {Colin A.} and Pierre Meneton and Andres Metspalu and Leena Moilanen and Morris, {Andrew D.} and Munroe, {Patricia B.} and Inger Nj{\o}lstad and Pedersen, {Nancy L.} and Chris Power and Pramstaller, {Peter P.} and Price, {Jackie F.} and Psaty, {Bruce M.} and Thomas Quertermous and Rainer Rauramaa and Danish Saleheen and Veikko Salomaa and Sanghera, {Dharambir K.} and Jouko Saramies and Schwarz, {Peter E. H.} and Sheu, {Wayne H.-H.} and Shuldiner, {Alan R.} and Agneta Siegbahn and Spector, {Tim D.} and Kari Stefansson and Strachan, {David P.} and Tayo, {Bamidele O.} and Elena Tremoli and Jaakko Tuomilehto and Matti Uusitupa and {van Duijn}, {Cornelia M.} and Peter Vollenweider and Lars Wallentin and Wareham, {Nicholas J.} and Whitfield, {John B.} and Wolffenbuttel, {Bruce H. R.} and David Altshuler and Ordovas, {Jose M.} and Eric Boerwinkle and Palmer, {Colin N. A.} and Unnur Thorsteinsdottir and Chasman, {Daniel I.} and Rotter, {Jerome I.} and Franks, {Paul W.} and Samuli Ripatti and Cupples, {L. Adrienne} and Sandhu, {Manjinder S.} and Rich, {Stephen S.} and Michael Boehnke and Panos Deloukas and Mohlke, {Karen L.} and Erik Ingelsson and Abecasis, {Goncalo R.} and Daly, {Mark J.} and Neale, {Benjamin M.} and Sekar Kathiresan",

year = "2013",

doi = "10.1038/ng.2795",

language = "English",

volume = "45",

pages = "1345--1352",

journal = "Nature Genetics",

issn = "1061-4036",

publisher = "Nature Research",

number = "11",

}

Do, R, Willer, CJ, Schmidt, EM, Sengupta, S, Gao, C, Peloso, GM, Gustafsson, S, Kanoni, S, Ganna, A, Chen, J, Buchkovich, ML, Mora, S, Beckmann, JS, Bragg-Gresham, JL, Chang, H-Y, Demirkan, A, Den Hertog, HM, Donnelly, LA, Ehret, GB, Esko, T, Feitosa, MF, Ferreira, T, Fischer, K, Fontanillas, P, Fraser, RM, Freitag, DF, Gurdasani, D, Heikkilä, K, Hyppönen, E, Isaacs, A, Jackson, AU, Johansson, A, Johnson, T, Kaakinen, M, Kettunen, J, Kleber, ME, Li, X, Luan, J, Lyytikäinen, L-P, Magnusson, PKE, Mangino, M, Mihailov, E, Montasser, ME, Müller-Nurasyid, M, Nolte, IM, O'Connell, JR, Palmer, CD, Perola, M, Petersen, A-K, Sanna, S, Saxena, R, Service, SK, Shah, S, Shungin, D, Sidore, C, Song, C, Strawbridge, RJ, Surakka, I, Tanaka, T, Teslovich, TM, Thorleifsson, G, Van den Herik, EG, Voight, BF, Volcik, KA, Waite, LL, Wong, A, Wu, Y, Zhang, W, Absher, D, Asiki, G, Barroso, I, Been, LF, Bolton, JL, Bonnycastle, LL, Brambilla, P, Burnett, MS, Cesana, G, Dimitriou, M, Doney, ASF, Döring, A, Elliott, P, Epstein, SE, Eyjolfsson, GI, Gigante, B, Goodarzi, MO, Grallert, H, Gravito, ML, Groves, CJ, Hallmans, G, Hartikainen, A-L, Hayward, C, Hernandez, D, Hicks, AA, Holm, H, Hung, Y-J, Illig, T, Jones, MR, Kaleebu, P, Kastelein, JJP, Khaw, K-T, Kim, E, Klopp, N, Komulainen, P, Kumari, M, Langenberg, C, Lehtimäki, T, Lin, S-Y, Lindström, J, Loos, RJF, Mach, F, McArdle, WL, Meisinger, C, Mitchell, BD, Müller, G, Nagaraja, R, Narisu, N, Nieminen, TVM, Nsubuga, RN, Olafsson, I, Ong, KK, Palotie, A, Papamarkou, T, Pomilla, C, Pouta, A, Rader, DJ, Reilly, MP, Ridker, PM, Rivadeneira, F, Rudan, I, Ruokonen, A, Samani, N, Scharnagl, H, Seeley, J, Silander, K, Stančáková, A, Stirrups, K, Swift, AJ, Tiret, L, Uitterlinden, AG, van Pelt, LJ, Vedantam, S, Wainwright, N, Wijmenga, C, Wild, SH, Willemsen, G, Wilsgaard, T, Wilson, JF, Young, EH, Zhao, JH, Adair, LS, Arveiler, D, Assimes, TL, Bandinelli, S, Bennett, F, Bochud, M, Boehm, BO, Boomsma, DI, Borecki, IB, Bornstein, SR, Bovet, P, Burnier, M, Campbell, H, Chakravarti, A, Chambers, JC, Chen, Y-DI, Collins, FS, Cooper, RS, Danesh, J, Dedoussis, G, de Faire, U, Feranil, AB, Ferrières, J, Ferrucci, L, Freimer, NB, Gieger, C, Groop, LC, Gudnason, V, Gyllensten, U, Hamsten, A, Harris, TB, Hingorani, A, Hirschhorn, JN, Hofman, A, Hovingh, GK, Hsiung, CA, Humphries, SE, Hunt, SC, Hveem, K, Iribarren, C, Järvelin, M-R, Jula, A, Kähönen, M, Kaprio, J, Kesäniemi, A, Kivimaki, M, Kooner, JS, Koudstaal, PJ, Krauss, RM, Kuh, D, Kuusisto, J, Kyvik, KO, Laakso, M, Lakka, TA, Lind, L, Lindgren, CM, Martin, NG, März, W, McCarthy, MI, McKenzie, CA, Meneton, P, Metspalu, A, Moilanen, L, Morris, AD, Munroe, PB, Njølstad, I, Pedersen, NL, Power, C, Pramstaller, PP, Price, JF, Psaty, BM, Quertermous, T, Rauramaa, R, Saleheen, D, Salomaa, V, Sanghera, DK, Saramies, J, Schwarz, PEH, Sheu, WH-H, Shuldiner, AR, Siegbahn, A, Spector, TD, Stefansson, K, Strachan, DP, Tayo, BO, Tremoli, E, Tuomilehto, J, Uusitupa, M, van Duijn, CM, Vollenweider, P, Wallentin, L, Wareham, NJ, Whitfield, JB, Wolffenbuttel, BHR, Altshuler, D, Ordovas, JM, Boerwinkle, E, Palmer, CNA, Thorsteinsdottir, U, Chasman, DI, Rotter, JI, Franks, PW, Ripatti, S, Cupples, LA, Sandhu, MS, Rich, SS, Boehnke, M, Deloukas, P, Mohlke, KL, Ingelsson, E, Abecasis, GR, Daly, MJ, Neale, BM & Kathiresan, S 2013, 'Common variants associated with plasma triglycerides and risk for coronary artery disease', Nature Genetics, vol. 45, no. 11, pp. 1345-1352. https://doi.org/10.1038/ng.2795

TY - JOUR

T1 - Common variants associated with plasma triglycerides and risk for coronary artery disease

AU - Do, Ron

AU - Willer, Cristen J.

AU - Schmidt, Ellen M.

AU - Sengupta, Sebanti

AU - Gao, Chi

AU - Peloso, Gina M.

AU - Gustafsson, Stefan

AU - Kanoni, Stavroula

AU - Ganna, Andrea

AU - Chen, Jin

AU - Buchkovich, Martin L.

AU - Mora, Samia

AU - Beckmann, Jacques S.

AU - Bragg-Gresham, Jennifer L.

AU - Chang, Hsing-Yi

AU - Demirkan, Ayşe

AU - Den Hertog, Heleen M.

AU - Donnelly, Louise A.

AU - Ehret, Georg B.

AU - Esko, Tõnu

AU - Feitosa, Mary F.

AU - Ferreira, Teresa

AU - Fischer, Krista

AU - Fontanillas, Pierre

AU - Fraser, Ross M.

AU - Freitag, Daniel F.

AU - Gurdasani, Deepti

AU - Heikkilä, Kauko

AU - Hyppönen, Elina

AU - Isaacs, Aaron

AU - Jackson, Anne U.

AU - Johansson, Asa

AU - Johnson, Toby

AU - Kaakinen, Marika

AU - Kettunen, Johannes

AU - Kleber, Marcus E.

AU - Li, Xiaohui

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PY - 2013

Y1 - 2013

N2 - Triglycerides are transported in plasma by specific triglyceride-rich lipoproteins; in epidemiological studies, increased triglyceride levels correlate with higher risk for coronary artery disease (CAD). However, it is unclear whether this association reflects causal processes. We used 185 common variants recently mapped for plasma lipids (P < 5 × 10 -8 for each) to examine the role of triglycerides in risk for CAD. First, we highlight loci associated with both low-density lipoprotein cholesterol (LDL-C) and triglyceride levels, and we show that the direction and magnitude of the associations with both traits are factors in determining CAD risk. Second, we consider loci with only a strong association with triglycerides and show that these loci are also associated with CAD. Finally, in a model accounting for effects on LDL-C and/or high-density lipoprotein cholesterol (HDL-C) levels, the strength of a polymorphism's effect on triglyceride levels is correlated with the magnitude of its effect on CAD risk. These results suggest that triglyceride-rich lipoproteins causally influence risk for CAD

AB - Triglycerides are transported in plasma by specific triglyceride-rich lipoproteins; in epidemiological studies, increased triglyceride levels correlate with higher risk for coronary artery disease (CAD). However, it is unclear whether this association reflects causal processes. We used 185 common variants recently mapped for plasma lipids (P < 5 × 10 -8 for each) to examine the role of triglycerides in risk for CAD. First, we highlight loci associated with both low-density lipoprotein cholesterol (LDL-C) and triglyceride levels, and we show that the direction and magnitude of the associations with both traits are factors in determining CAD risk. Second, we consider loci with only a strong association with triglycerides and show that these loci are also associated with CAD. Finally, in a model accounting for effects on LDL-C and/or high-density lipoprotein cholesterol (HDL-C) levels, the strength of a polymorphism's effect on triglyceride levels is correlated with the magnitude of its effect on CAD risk. These results suggest that triglyceride-rich lipoproteins causally influence risk for CAD

U2 - 10.1038/ng.2795

DO - 10.1038/ng.2795

M3 - Letter

C2 - 24097064

SN - 1061-4036

VL - 45

SP - 1345

EP - 1352

JO - Nature Genetics

JF - Nature Genetics

IS - 11

ER -

Common variants associated with plasma triglycerides and risk for coronary artery disease

Abstract

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