Common variants in WFS1 confer risk of type 2 diabetes

Manjinder S. Sandhu; Michael N. Weedon; Katherine A. Fawcett; Jon Wasson; Sally L. Debenham; Allan Daly; Hana Lango; Timothy M. Frayling; Rosalind J. Neumann; Richard Sherva; Ilana Blech; Paul D. Pharoah; Colin N.A. Palmer; Charlotte Kimber; Roger Tavendale; Andrew D. Morris; Mark I. McCarthy; Mark Walker; Graham Hitman; Benjamin Glaser; M. Alan Permutt; Andrew T. Hattersley; Nicholas J. Wareham; Inês Barroso

doi:10.1038/ng2067

Common variants in WFS1 confer risk of type 2 diabetes

Manjinder S. Sandhu, Michael N. Weedon, Katherine A. Fawcett, Jon Wasson, Sally L. Debenham, Allan Daly, Hana Lango, Timothy M. Frayling, Rosalind J. Neumann, Richard Sherva, Ilana Blech, Paul D. Pharoah, Colin N.A. Palmer, Charlotte Kimber, Roger Tavendale, Andrew D. Morris, Mark I. McCarthy, Mark Walker, Graham Hitman, Benjamin GlaserM. Alan Permutt, Andrew T. Hattersley, Nicholas J. Wareham, Inês Barroso

Research output: Contribution to journal › Article › peer-review

317 Citations (Scopus)

Abstract

We studied genes involved in pancreatic β cell function and survival, identifying associations between SNPs in WFS1 and diabetes risk in UK populations that we replicated in an Ashkenazi population and in additional UK studies. In a pooled analysis comprising 9,533 cases and 11,389 controls, SNPs in WFS1 were strongly associated with diabetes risk. Rare mutations in WFS1 cause Wolfram syndrome; using a gene-centric approach, we show that variation in WFS1 also predisposes to common type 2 diabetes.

Original language	English
Pages (from-to)	951-953
Number of pages	3
Journal	Nature Genetics
Volume	39
Issue number	8
DOIs	https://doi.org/10.1038/ng2067
Publication status	Published - 1 Aug 2007

ASJC Scopus subject areas

Genetics

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1038/ng2067

Cite this

Sandhu, M. S., Weedon, M. N., Fawcett, K. A., Wasson, J., Debenham, S. L., Daly, A., Lango, H., Frayling, T. M., Neumann, R. J., Sherva, R., Blech, I., Pharoah, P. D., Palmer, C. N. A., Kimber, C., Tavendale, R., Morris, A. D., McCarthy, M. I., Walker, M., Hitman, G., ... Barroso, I. (2007). Common variants in WFS1 confer risk of type 2 diabetes. Nature Genetics, 39(8), 951-953. https://doi.org/10.1038/ng2067

@article{82ca9ca1d928480b88385005680c66e6,

title = "Common variants in WFS1 confer risk of type 2 diabetes",

abstract = "We studied genes involved in pancreatic β cell function and survival, identifying associations between SNPs in WFS1 and diabetes risk in UK populations that we replicated in an Ashkenazi population and in additional UK studies. In a pooled analysis comprising 9,533 cases and 11,389 controls, SNPs in WFS1 were strongly associated with diabetes risk. Rare mutations in WFS1 cause Wolfram syndrome; using a gene-centric approach, we show that variation in WFS1 also predisposes to common type 2 diabetes.",

author = "Sandhu, {Manjinder S.} and Weedon, {Michael N.} and Fawcett, {Katherine A.} and Jon Wasson and Debenham, {Sally L.} and Allan Daly and Hana Lango and Frayling, {Timothy M.} and Neumann, {Rosalind J.} and Richard Sherva and Ilana Blech and Pharoah, {Paul D.} and Palmer, {Colin N.A.} and Charlotte Kimber and Roger Tavendale and Morris, {Andrew D.} and McCarthy, {Mark I.} and Mark Walker and Graham Hitman and Benjamin Glaser and Permutt, {M. Alan} and Hattersley, {Andrew T.} and Wareham, {Nicholas J.} and In{\^e}s Barroso",

year = "2007",

month = aug,

day = "1",

doi = "10.1038/ng2067",

language = "English",

volume = "39",

pages = "951--953",

journal = "Nature Genetics",

issn = "1061-4036",

publisher = "Nature Research",

number = "8",

}

Sandhu, MS, Weedon, MN, Fawcett, KA, Wasson, J, Debenham, SL, Daly, A, Lango, H, Frayling, TM, Neumann, RJ, Sherva, R, Blech, I, Pharoah, PD, Palmer, CNA, Kimber, C, Tavendale, R, Morris, AD, McCarthy, MI, Walker, M, Hitman, G, Glaser, B, Permutt, MA, Hattersley, AT, Wareham, NJ & Barroso, I 2007, 'Common variants in WFS1 confer risk of type 2 diabetes', Nature Genetics, vol. 39, no. 8, pp. 951-953. https://doi.org/10.1038/ng2067

TY - JOUR

T1 - Common variants in WFS1 confer risk of type 2 diabetes

AU - Sandhu, Manjinder S.

AU - Weedon, Michael N.

AU - Fawcett, Katherine A.

AU - Wasson, Jon

AU - Debenham, Sally L.

AU - Daly, Allan

AU - Lango, Hana

AU - Frayling, Timothy M.

AU - Neumann, Rosalind J.

AU - Sherva, Richard

AU - Blech, Ilana

AU - Pharoah, Paul D.

AU - Palmer, Colin N.A.

AU - Kimber, Charlotte

AU - Tavendale, Roger

AU - Morris, Andrew D.

AU - McCarthy, Mark I.

AU - Walker, Mark

AU - Hitman, Graham

AU - Glaser, Benjamin

AU - Permutt, M. Alan

AU - Hattersley, Andrew T.

AU - Wareham, Nicholas J.

AU - Barroso, Inês

PY - 2007/8/1

Y1 - 2007/8/1

N2 - We studied genes involved in pancreatic β cell function and survival, identifying associations between SNPs in WFS1 and diabetes risk in UK populations that we replicated in an Ashkenazi population and in additional UK studies. In a pooled analysis comprising 9,533 cases and 11,389 controls, SNPs in WFS1 were strongly associated with diabetes risk. Rare mutations in WFS1 cause Wolfram syndrome; using a gene-centric approach, we show that variation in WFS1 also predisposes to common type 2 diabetes.

AB - We studied genes involved in pancreatic β cell function and survival, identifying associations between SNPs in WFS1 and diabetes risk in UK populations that we replicated in an Ashkenazi population and in additional UK studies. In a pooled analysis comprising 9,533 cases and 11,389 controls, SNPs in WFS1 were strongly associated with diabetes risk. Rare mutations in WFS1 cause Wolfram syndrome; using a gene-centric approach, we show that variation in WFS1 also predisposes to common type 2 diabetes.

U2 - 10.1038/ng2067

DO - 10.1038/ng2067

M3 - Article

C2 - 17603484

AN - SCOPUS:34547536393

SN - 1061-4036

VL - 39

SP - 951

EP - 953

JO - Nature Genetics

JF - Nature Genetics

IS - 8

ER -

Common variants in WFS1 confer risk of type 2 diabetes

Abstract

ASJC Scopus subject areas

UN SDGs

Access to Document

Fingerprint

Cite this