Common variants in WFS1 confer risk of type 2 diabetes

Manjinder S. Sandhu, Michael N. Weedon, Katherine A. Fawcett, Jon Wasson, Sally L. Debenham, Allan Daly, Hana Lango, Timothy M. Frayling, Rosalind J. Neumann, Richard Sherva, Ilana Blech, Paul D. Pharoah, Colin N.A. Palmer, Charlotte Kimber, Roger Tavendale, Andrew D. Morris, Mark I. McCarthy, Mark Walker, Graham Hitman, Benjamin GlaserM. Alan Permutt, Andrew T. Hattersley, Nicholas J. Wareham, Inês Barroso

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    266 Citations (Scopus)

    Abstract

    We studied genes involved in pancreatic β cell function and survival, identifying associations between SNPs in WFS1 and diabetes risk in UK populations that we replicated in an Ashkenazi population and in additional UK studies. In a pooled analysis comprising 9,533 cases and 11,389 controls, SNPs in WFS1 were strongly associated with diabetes risk. Rare mutations in WFS1 cause Wolfram syndrome; using a gene-centric approach, we show that variation in WFS1 also predisposes to common type 2 diabetes.

    Original languageEnglish
    Pages (from-to)951-953
    Number of pages3
    JournalNature Genetics
    Volume39
    Issue number8
    DOIs
    Publication statusPublished - 1 Aug 2007

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  • Cite this

    Sandhu, M. S., Weedon, M. N., Fawcett, K. A., Wasson, J., Debenham, S. L., Daly, A., Lango, H., Frayling, T. M., Neumann, R. J., Sherva, R., Blech, I., Pharoah, P. D., Palmer, C. N. A., Kimber, C., Tavendale, R., Morris, A. D., McCarthy, M. I., Walker, M., Hitman, G., ... Barroso, I. (2007). Common variants in WFS1 confer risk of type 2 diabetes. Nature Genetics, 39(8), 951-953. https://doi.org/10.1038/ng2067