Common variants in WFS1 confer risk of type 2 diabetes

Manjinder S. Sandhu; Michael N. Weedon; Katherine A. Fawcett; Jon Wasson; Sally L. Debenham; Allan Daly; Hana Lango; Timothy M. Frayling; Rosalind J. Neumann; Richard Sherva; Ilana Blech; Paul D. Pharoah; Colin N.A. Palmer; Charlotte Kimber; Roger Tavendale; Andrew D. Morris; Mark I. McCarthy; Mark Walker; Graham Hitman; Benjamin Glaser; M. Alan Permutt; Andrew T. Hattersley; Nicholas J. Wareham; Inês Barroso

doi:10.1038/ng2067

Common variants in WFS1 confer risk of type 2 diabetes

Manjinder S. Sandhu
, Michael N. Weedon
, Katherine A. Fawcett
, Jon Wasson
, Sally L. Debenham
, Allan Daly
, Hana Lango
, Timothy M. Frayling
, Rosalind J. Neumann
, Richard Sherva
, Ilana Blech
, Paul D. Pharoah
, Colin N.A. Palmer
, Charlotte Kimber
, Roger Tavendale
, Andrew D. Morris
, Mark I. McCarthy
, Mark Walker
, Graham Hitman
, Benjamin Glaser

M. Alan Permutt, Andrew T. Hattersley, Nicholas J. Wareham, Inês Barroso

Research output: Contribution to journal › Article › peer-review

330 Citations (Scopus)

Abstract

We studied genes involved in pancreatic β cell function and survival, identifying associations between SNPs in WFS1 and diabetes risk in UK populations that we replicated in an Ashkenazi population and in additional UK studies. In a pooled analysis comprising 9,533 cases and 11,389 controls, SNPs in WFS1 were strongly associated with diabetes risk. Rare mutations in WFS1 cause Wolfram syndrome; using a gene-centric approach, we show that variation in WFS1 also predisposes to common type 2 diabetes.

Original language	English
Pages (from-to)	951-953
Number of pages	3
Journal	Nature Genetics
Volume	39
Issue number	8
DOIs	https://doi.org/10.1038/ng2067
Publication status	Published - 1 Aug 2007

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

ASJC Scopus subject areas

Genetics

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10.1038/ng2067

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Sandhu, M. S., Weedon, M. N., Fawcett, K. A., Wasson, J., Debenham, S. L., Daly, A., Lango, H., Frayling, T. M., Neumann, R. J., Sherva, R., Blech, I., Pharoah, P. D., Palmer, C. N. A., Kimber, C., Tavendale, R., Morris, A. D., McCarthy, M. I., Walker, M., Hitman, G., ... Barroso, I. (2007). Common variants in WFS1 confer risk of type 2 diabetes. Nature Genetics, 39(8), 951-953. https://doi.org/10.1038/ng2067

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title = "Common variants in WFS1 confer risk of type 2 diabetes",

abstract = "We studied genes involved in pancreatic β cell function and survival, identifying associations between SNPs in WFS1 and diabetes risk in UK populations that we replicated in an Ashkenazi population and in additional UK studies. In a pooled analysis comprising 9,533 cases and 11,389 controls, SNPs in WFS1 were strongly associated with diabetes risk. Rare mutations in WFS1 cause Wolfram syndrome; using a gene-centric approach, we show that variation in WFS1 also predisposes to common type 2 diabetes.",

author = "Sandhu, \{Manjinder S.\} and Weedon, \{Michael N.\} and Fawcett, \{Katherine A.\} and Jon Wasson and Debenham, \{Sally L.\} and Allan Daly and Hana Lango and Frayling, \{Timothy M.\} and Neumann, \{Rosalind J.\} and Richard Sherva and Ilana Blech and Pharoah, \{Paul D.\} and Palmer, \{Colin N.A.\} and Charlotte Kimber and Roger Tavendale and Morris, \{Andrew D.\} and McCarthy, \{Mark I.\} and Mark Walker and Graham Hitman and Benjamin Glaser and Permutt, \{M. Alan\} and Hattersley, \{Andrew T.\} and Wareham, \{Nicholas J.\} and In{\^e}s Barroso",

year = "2007",

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doi = "10.1038/ng2067",

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pages = "951--953",

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Sandhu, MS, Weedon, MN, Fawcett, KA, Wasson, J, Debenham, SL, Daly, A, Lango, H, Frayling, TM, Neumann, RJ, Sherva, R, Blech, I, Pharoah, PD, Palmer, CNA, Kimber, C, Tavendale, R, Morris, AD, McCarthy, MI, Walker, M, Hitman, G, Glaser, B, Permutt, MA, Hattersley, AT, Wareham, NJ & Barroso, I 2007, 'Common variants in WFS1 confer risk of type 2 diabetes', Nature Genetics, vol. 39, no. 8, pp. 951-953. https://doi.org/10.1038/ng2067

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T1 - Common variants in WFS1 confer risk of type 2 diabetes

AU - Sandhu, Manjinder S.

AU - Weedon, Michael N.

AU - Fawcett, Katherine A.

AU - Wasson, Jon

AU - Debenham, Sally L.

AU - Daly, Allan

AU - Lango, Hana

AU - Frayling, Timothy M.

AU - Neumann, Rosalind J.

AU - Sherva, Richard

AU - Blech, Ilana

AU - Pharoah, Paul D.

AU - Palmer, Colin N.A.

AU - Kimber, Charlotte

AU - Tavendale, Roger

AU - Morris, Andrew D.

AU - McCarthy, Mark I.

AU - Walker, Mark

AU - Hitman, Graham

AU - Glaser, Benjamin

AU - Permutt, M. Alan

AU - Hattersley, Andrew T.

AU - Wareham, Nicholas J.

AU - Barroso, Inês

PY - 2007/8/1

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AB - We studied genes involved in pancreatic β cell function and survival, identifying associations between SNPs in WFS1 and diabetes risk in UK populations that we replicated in an Ashkenazi population and in additional UK studies. In a pooled analysis comprising 9,533 cases and 11,389 controls, SNPs in WFS1 were strongly associated with diabetes risk. Rare mutations in WFS1 cause Wolfram syndrome; using a gene-centric approach, we show that variation in WFS1 also predisposes to common type 2 diabetes.

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DO - 10.1038/ng2067

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AN - SCOPUS:34547536393

SN - 1061-4036

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EP - 953

JO - Nature Genetics

JF - Nature Genetics

IS - 8

ER -

Common variants in WFS1 confer risk of type 2 diabetes

Abstract

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ASJC Scopus subject areas

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