Abstract
The H1N1 influenza A virus lifted the global and marketed the drugs of zanamivir and oseltamivir. The study of the above mentioned drugs is along with the specific inhibitor neuraminidase. The expected outbreak of the observation has identified the sisomycin and other derivatives have a better resistance of comparing to the other chemical molecules. Thus, the structures with various complexes produced some reports against influenza, open conformation also analyzed in the same regions of the 150-loop (Gly147-Asp151). We investigated the binding position and pharmacophoric properties of sisomycin resistance of influenza A (H1N1) virus. This is aimed for comparing the related structures of sisomycin with similarity and docked with various algorithms; it is useful for designing neuraminidase inhibitors.
| Original language | English |
|---|---|
| Pages (from-to) | 83-85 |
| Number of pages | 3 |
| Journal | International Journal of Pharmacy and Pharmaceutical Sciences |
| Volume | 2 |
| Issue number | 3 |
| Publication status | Published - Jul 2010 |
Keywords
- H1N1
- Influenza virus
- Neuraminidase inhibitors
- Pandemic disease
- Zanamivir