Comparison between the Astaxanthin Release Profile of Mesoporous Bioactive Glass Nanoparticles (MBGNs) and Poly (3-Hydroxybutyrate-Co-3-Hydroxyvalerate) (PHBV)/MBGN Composite Microspheres

Arturo E. Aguilar-Rabiela, Shahin Homaeigohar, Eduin I. González-Castillo, Mirna L. Sánchez, Aldo R. Boccaccini (Lead / Corresponding author)

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Abstract

Composite biomaterials for drug delivery applications have attracted attention in the last years due to the possibility of combining desired properties from their components. However, some aspects such as their drug release efficiency and likely side effects are still unexplored. In this regard, controlled tunning of the release kinetic by precise design of a composite particle system is still of large interest for many biomedical applications. Accordingly, one interesting strategy is the combination of different biomaterials with unequal release rates such as mesoporous bioactive glass nanoparticles (MBGN) and poly (3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) microspheres. In this work, MBGNs and PHBV-MBGN microspheres, both loaded with Astaxanthin (ASX), were synthesized and compared in terms of ASX release kinetic, ASX entrapment efficiency and cell viability. The correlation of the release kinetic to phytotherapeutic efficiency and side effects was established. Interestingly, there were significant differences between the release kinetic of the developed systems and cell viability differed accordingly after 72 h. Both particle carriers showed promise in delivery of ASX, though the composite microspheres exhibited a more prolonged release profile with sustained cytocompatibility. Additionally, the release behaviour could be fine-tuned by adjusting the MBGN content in the composite particles. Lastly, the composite particles induced a different release effect implying their potential for sustained drug delivery applications.
Original languageEnglish
Article number2432
Number of pages13
JournalPolymers
Volume15
Issue number11
Early online date24 May 2023
DOIs
Publication statusPublished - Jun 2023

Keywords

  • Astaxanthin
  • composite microspheres
  • sustained release
  • controlled release

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