TY - JOUR
T1 - Comparison between the Astaxanthin Release Profile of Mesoporous Bioactive Glass Nanoparticles (MBGNs) and Poly (3-Hydroxybutyrate-Co-3-Hydroxyvalerate) (PHBV)/MBGN Composite Microspheres
AU - Aguilar-Rabiela, Arturo E.
AU - Homaeigohar, Shahin
AU - González-Castillo, Eduin I.
AU - Sánchez, Mirna L.
AU - Boccaccini, Aldo R.
N1 - Funding Information:
We acknowledge the technical staff of the Institute of Biomaterials of Friedrich-Alexander Universität (FAU) for the technical support and the Deutscher Akademischer Austauschdienst (DAAD) for the funding (Program Ref. 57552340). MLS acknowledges CONICET and Universidad Nacional de Quilmes, (Argentina).
Copyright:
© 2023 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2023/6
Y1 - 2023/6
N2 - Composite biomaterials for drug delivery applications have attracted attention in the last years due to the possibility of combining desired properties from their components. However, some aspects such as their drug release efficiency and likely side effects are still unexplored. In this regard, controlled tunning of the release kinetic by precise design of a composite particle system is still of large interest for many biomedical applications. Accordingly, one interesting strategy is the combination of different biomaterials with unequal release rates such as mesoporous bioactive glass nanoparticles (MBGN) and poly (3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) microspheres. In this work, MBGNs and PHBV-MBGN microspheres, both loaded with Astaxanthin (ASX), were synthesized and compared in terms of ASX release kinetic, ASX entrapment efficiency and cell viability. The correlation of the release kinetic to phytotherapeutic efficiency and side effects was established. Interestingly, there were significant differences between the release kinetic of the developed systems and cell viability differed accordingly after 72 h. Both particle carriers showed promise in delivery of ASX, though the composite microspheres exhibited a more prolonged release profile with sustained cytocompatibility. Additionally, the release behaviour could be fine-tuned by adjusting the MBGN content in the composite particles. Lastly, the composite particles induced a different release effect implying their potential for sustained drug delivery applications.
AB - Composite biomaterials for drug delivery applications have attracted attention in the last years due to the possibility of combining desired properties from their components. However, some aspects such as their drug release efficiency and likely side effects are still unexplored. In this regard, controlled tunning of the release kinetic by precise design of a composite particle system is still of large interest for many biomedical applications. Accordingly, one interesting strategy is the combination of different biomaterials with unequal release rates such as mesoporous bioactive glass nanoparticles (MBGN) and poly (3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) microspheres. In this work, MBGNs and PHBV-MBGN microspheres, both loaded with Astaxanthin (ASX), were synthesized and compared in terms of ASX release kinetic, ASX entrapment efficiency and cell viability. The correlation of the release kinetic to phytotherapeutic efficiency and side effects was established. Interestingly, there were significant differences between the release kinetic of the developed systems and cell viability differed accordingly after 72 h. Both particle carriers showed promise in delivery of ASX, though the composite microspheres exhibited a more prolonged release profile with sustained cytocompatibility. Additionally, the release behaviour could be fine-tuned by adjusting the MBGN content in the composite particles. Lastly, the composite particles induced a different release effect implying their potential for sustained drug delivery applications.
KW - Astaxanthin
KW - composite microspheres
KW - sustained release
KW - controlled release
UR - http://www.scopus.com/inward/record.url?scp=85161544792&partnerID=8YFLogxK
U2 - 10.3390/polym15112432
DO - 10.3390/polym15112432
M3 - Article
C2 - 37299231
SN - 2073-4360
VL - 15
JO - Polymers
JF - Polymers
IS - 11
M1 - 2432
ER -