Comparison of fluorouracil with additional levamisole, higher-dose folinic acid, or both, as adjuvant chemotherapy for colorectal cancer: a randomised trial.

QUASAR Collaborative Group

    Research output: Contribution to journalArticle

    228 Citations (Scopus)

    Abstract

    Standard adjuvant chemotherapy for colorectal cancer consists of fluorouracil with folinic acid or levamisole. The large QUASAR randomised trial aimed to investigate (in a two x two design) whether use of a higher dose of folinic acid or addition of levamisole to fluorouracil and folinic acid improved survival.
    Original languageEnglish
    Pages (from-to)1588-96
    Number of pages9
    JournalLancet
    Volume355
    Issue number9215
    DOIs
    Publication statusPublished - 6 May 2000

    Keywords

    • Adjuvants, Immunologic
    • Antimetabolites, Antineoplastic
    • Chemotherapy, Adjuvant
    • Colonic Neoplasms
    • Drug Therapy, Combination
    • Fluorouracil
    • Humans
    • Leucovorin
    • Levamisole
    • Neoplasm Recurrence, Local
    • Radiotherapy, Adjuvant
    • Rectal Neoplasms
    • Survival Analysis

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