Comparison of mammographic findings after intraoperative radiotherapy or external beam whole breast radiotherapy

B. Elsberger (Lead / Corresponding author), A. Romsauerova, S. Vinnicombe, P. Whelehan, D. C. Brown, J. A. Dewar, A. M. Thompson, A. Evans

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    14 Citations (Scopus)


    Background: The TARGIT (TARGeted Intraoperative Radiotherapy) trial was designed to compare local recurrence and complication rates in breast cancer patients, prospectively randomised to either EBRT (external beam whole breast radiotherapy) or a single dose of IORT (intraoperative radiotherapy). The aim of our study was to compare follow-up mammographic findings, ultrasound and biopsy rates in each group.

    Methods: Follow-up imaging and breast biopsies of women from one centre participating in the TARGIT-A trial were independently reviewed by two radiologists blinded to the radiotherapy treatment received.

    Results: The cohort consisted of 141 patients (EBRT n = 80/IORT n = 61). There was no significant difference in the patient or disease characteristics of the two groups. The number of follow-up mammograms and length of follow-up was similar (EBRT/IORT n = 2.0/2.4; 4.3yr/5.1yr; p = 0.386 x2 test). There were no significant differences in mammographic scar or calcification appearances of the post-operative site. Generalised increase in breast density and skin thickening were more common in the EBRT compared to the IORT group (p = 0.002; p = 0.030, x2test respectively). A trend towards additional ultrasound at follow-up was observed in the IORT group (15 of 61 [24.6%] versus 11 of 80 [13.8%]), however this was not statistically significant (p = 0.100 x2 test). No disease recurrence was demonstrated on any of the breast biopsies taken. Only one biopsy was reported as fat necrosis in the IORT group.

    Conclusions: Mammographic changes were more common following EBRT, although more additional follow-up ultrasounds were performed in the IORT group. IORT is not detrimental to subsequent radiological follow up. © 2013 Elsevier Ltd. All rights reserved.

    Original languageEnglish
    Pages (from-to)163-167
    Number of pages5
    JournalEJSO - European Journal of Surgical Oncology
    Issue number2
    Early online date4 Dec 2013
    Publication statusPublished - Feb 2014


    • TARGIT-A trial
    • Early breast cancer
    • IORT
    • EBRT


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