Comparison of mammographic findings after intraoperative radiotherapy or external beam whole breast radiotherapy

TY - JOUR

T1 - Comparison of mammographic findings after intraoperative radiotherapy or external beam whole breast radiotherapy

AU - Elsberger, B.

AU - Romsauerova, A.

AU - Vinnicombe, S.

AU - Whelehan, P.

AU - Brown, D. C.

AU - Dewar, J. A.

AU - Thompson, A. M.

AU - Evans, A.

N1 - Copyright © 2013. Published by Elsevier Ltd.

PY - 2014/2

Y1 - 2014/2

N2 - Background: The TARGIT (TARGeted Intraoperative Radiotherapy) trial was designed to compare local recurrence and complication rates in breast cancer patients, prospectively randomised to either EBRT (external beam whole breast radiotherapy) or a single dose of IORT (intraoperative radiotherapy). The aim of our study was to compare follow-up mammographic findings, ultrasound and biopsy rates in each group.Methods: Follow-up imaging and breast biopsies of women from one centre participating in the TARGIT-A trial were independently reviewed by two radiologists blinded to the radiotherapy treatment received.Results: The cohort consisted of 141 patients (EBRT n = 80/IORT n = 61). There was no significant difference in the patient or disease characteristics of the two groups. The number of follow-up mammograms and length of follow-up was similar (EBRT/IORT n = 2.0/2.4; 4.3yr/5.1yr; p = 0.386 x2 test). There were no significant differences in mammographic scar or calcification appearances of the post-operative site. Generalised increase in breast density and skin thickening were more common in the EBRT compared to the IORT group (p = 0.002; p = 0.030, x2test respectively). A trend towards additional ultrasound at follow-up was observed in the IORT group (15 of 61 [24.6%] versus 11 of 80 [13.8%]), however this was not statistically significant (p = 0.100 x2 test). No disease recurrence was demonstrated on any of the breast biopsies taken. Only one biopsy was reported as fat necrosis in the IORT group.Conclusions: Mammographic changes were more common following EBRT, although more additional follow-up ultrasounds were performed in the IORT group. IORT is not detrimental to subsequent radiological follow up. © 2013 Elsevier Ltd. All rights reserved.

AB - Background: The TARGIT (TARGeted Intraoperative Radiotherapy) trial was designed to compare local recurrence and complication rates in breast cancer patients, prospectively randomised to either EBRT (external beam whole breast radiotherapy) or a single dose of IORT (intraoperative radiotherapy). The aim of our study was to compare follow-up mammographic findings, ultrasound and biopsy rates in each group.Methods: Follow-up imaging and breast biopsies of women from one centre participating in the TARGIT-A trial were independently reviewed by two radiologists blinded to the radiotherapy treatment received.Results: The cohort consisted of 141 patients (EBRT n = 80/IORT n = 61). There was no significant difference in the patient or disease characteristics of the two groups. The number of follow-up mammograms and length of follow-up was similar (EBRT/IORT n = 2.0/2.4; 4.3yr/5.1yr; p = 0.386 x2 test). There were no significant differences in mammographic scar or calcification appearances of the post-operative site. Generalised increase in breast density and skin thickening were more common in the EBRT compared to the IORT group (p = 0.002; p = 0.030, x2test respectively). A trend towards additional ultrasound at follow-up was observed in the IORT group (15 of 61 [24.6%] versus 11 of 80 [13.8%]), however this was not statistically significant (p = 0.100 x2 test). No disease recurrence was demonstrated on any of the breast biopsies taken. Only one biopsy was reported as fat necrosis in the IORT group.Conclusions: Mammographic changes were more common following EBRT, although more additional follow-up ultrasounds were performed in the IORT group. IORT is not detrimental to subsequent radiological follow up. © 2013 Elsevier Ltd. All rights reserved.

KW - TARGIT-A trial

KW - Early breast cancer

KW - IORT

KW - EBRT

UR - https://www.scopus.com/pages/publications/84895071898

U2 - 10.1016/j.ejso.2013.11.011

DO - 10.1016/j.ejso.2013.11.011

M3 - Article

C2 - 24332581

SN - 0748-7983

VL - 40

SP - 163

EP - 167

JO - EJSO - European Journal of Surgical Oncology

JF - EJSO - European Journal of Surgical Oncology

IS - 2

ER -