TY - JOUR
T1 - Comparison of Oocyte and Embryo Quality Between Random Start and Controlled Ovarian Stimulation Cycles in Cancer Patients Undergoing Fertility Preservation
AU - Israfilova, Guler
AU - Sukur, Yavuz Emre
AU - Ozkavukcu, Sinan
AU - Sonmezer, Meltem Aksu
AU - Atabekoglu, Cem Somer
AU - Ozmen, Batuhan
AU - Berker, Bulent
AU - Aytac, Rusen
AU - Koc, Acar
AU - Sonmezer, Murat
PY - 2021/8/1
Y1 - 2021/8/1
N2 - Conventional assisted reproductive technology (ART) cycles may delay cancer treatment and compromise survival, and also increase patients’ psychological burden as a result of delayed chemotherapy. The aim of this study was to compare the success rates of random start and conventional start GnRH antagonist protocols in terms of oocyte and embryo outputs in cancer patients. Data of 111 patients with a newly diagnosed cancer who underwent ART for fertility preservation at a university-based infertility clinic between January 2010 and September 2019 were reviewed. The study group underwent random start controlled ovarian hyperstimulation (RS-COH) and the control group underwent conventional start COH (CS-COH). The main outcome measures were the number of total oocytes, MII oocytes, and embryo yield. A total of 46 patients (41.5%) underwent RS-COH and 65 (58.5%) underwent CS-COH. Baseline characteristics were similar between the groups. The most common cancer type in both groups was breast cancer (60.9% vs. 52.3%, respectively). The median duration of stimulation was significantly longer in RS-COH than in CS-COH (12 vs. 10 days; P = 0.005). The median number of MII oocytes was significantly higher in RS-COH than in CS-COH (7 vs. 5 oocytes, respectively; P = 0.020). The MII/AFC ratio was significantly higher in the RS-COH group compared to the CS-COH group (74% and 57% respectively; p = 0.02). In the linear regression analyses, RS-COH protocol did not have a significant impact on MII/AFC (standardized ß coefficient − 0.514; P = 0.289 {adjusted R
2 for the model = 0.779}), oocyte yield (standardized ß coefficient − 0.070; P = 0.829 {adjusted R
2 for the model = 0.840}), and MII rate (standardized ß coefficient − 0.504; P = 0.596 {adjusted R
2 for the model = 0.271}). In conclusion, RS-COH protocol is as effective as CS-COH protocols for fertility preservation in cancer patients.
AB - Conventional assisted reproductive technology (ART) cycles may delay cancer treatment and compromise survival, and also increase patients’ psychological burden as a result of delayed chemotherapy. The aim of this study was to compare the success rates of random start and conventional start GnRH antagonist protocols in terms of oocyte and embryo outputs in cancer patients. Data of 111 patients with a newly diagnosed cancer who underwent ART for fertility preservation at a university-based infertility clinic between January 2010 and September 2019 were reviewed. The study group underwent random start controlled ovarian hyperstimulation (RS-COH) and the control group underwent conventional start COH (CS-COH). The main outcome measures were the number of total oocytes, MII oocytes, and embryo yield. A total of 46 patients (41.5%) underwent RS-COH and 65 (58.5%) underwent CS-COH. Baseline characteristics were similar between the groups. The most common cancer type in both groups was breast cancer (60.9% vs. 52.3%, respectively). The median duration of stimulation was significantly longer in RS-COH than in CS-COH (12 vs. 10 days; P = 0.005). The median number of MII oocytes was significantly higher in RS-COH than in CS-COH (7 vs. 5 oocytes, respectively; P = 0.020). The MII/AFC ratio was significantly higher in the RS-COH group compared to the CS-COH group (74% and 57% respectively; p = 0.02). In the linear regression analyses, RS-COH protocol did not have a significant impact on MII/AFC (standardized ß coefficient − 0.514; P = 0.289 {adjusted R
2 for the model = 0.779}), oocyte yield (standardized ß coefficient − 0.070; P = 0.829 {adjusted R
2 for the model = 0.840}), and MII rate (standardized ß coefficient − 0.504; P = 0.596 {adjusted R
2 for the model = 0.271}). In conclusion, RS-COH protocol is as effective as CS-COH protocols for fertility preservation in cancer patients.
KW - Controlled ovarian hyperstimulation
KW - Cryopreservation
KW - Fertility preservation
KW - Oocyte yield
KW - Random start
UR - http://www.scopus.com/inward/record.url?scp=85099065735&partnerID=8YFLogxK
U2 - 10.1007/s43032-020-00412-2
DO - 10.1007/s43032-020-00412-2
M3 - Article
C2 - 33409878
VL - 28
SP - 2200
EP - 2207
JO - Reproductive Sciences
JF - Reproductive Sciences
SN - 1933-7191
IS - 8
ER -
