Comparison of the reproducibility of quantitative cardiac left ventricular assessments in healthy volunteers using different MRI scanners: a multicenter simulation

TY - JOUR

T1 - Comparison of the reproducibility of quantitative cardiac left ventricular assessments in healthy volunteers using different MRI scanners

T2 - a multicenter simulation

AU - Gandy, Stephen J.

AU - Waugh, Shelley A.

AU - Nicholas, R. Stephen

AU - Simpson, Helen J.

AU - Milne, Wendy

AU - Houston, J. Graeme

PY - 2008/8

Y1 - 2008/8

N2 - Purpose: To derive reproducibility assessments of ejection fraction (EF) and left ventricular mass (LVM) from shortaxis cardiac MR images acquired at single and multiple time-points on different 1.5T scanner models.Materials and Methods: Images of 15 healthy volunteers were acquired twice using a Magnetom Avanto scanner (Siemens, Erlangen, Germany) and once using a Signa Excite scanner (General Electric, Milwaukee, WI, USA) over four months, and analyzed using ARGUS and MASS Analysis+ software, respectively. Two physicists independently segmented the myocardial borders in order to derive intraand interobserver assessments of EF and LVM for single and multiple time-points on the same and different scanners.Results: For EF, the coefficient of repeatability (CoR) increased as different observers, multiple time-points, and different scanners were introduced. The CoR ranged from 2.8% (intraobserver measurements, single time-point, same scanner) to 10.0% (interobserver measurements, different timepoints, different scanners). For LVM, intraobserver CoR parameters were consistently smaller than interobserver values. The CoR ranged from 7.8 g (intraobserver measurements, single time-point, same scanner) to 39.5 g (interobserver measurements, different time-points, different scanners).Conclusion: Reproducible EF data can be obtained at single or multiple time-points. using different scanners. However, LUM is notably susceptible to interobserver variation, and this should be carefully considered if similar evaluations are planned as part of multicenter or longitudinal investigations.

AB - Purpose: To derive reproducibility assessments of ejection fraction (EF) and left ventricular mass (LVM) from shortaxis cardiac MR images acquired at single and multiple time-points on different 1.5T scanner models.Materials and Methods: Images of 15 healthy volunteers were acquired twice using a Magnetom Avanto scanner (Siemens, Erlangen, Germany) and once using a Signa Excite scanner (General Electric, Milwaukee, WI, USA) over four months, and analyzed using ARGUS and MASS Analysis+ software, respectively. Two physicists independently segmented the myocardial borders in order to derive intraand interobserver assessments of EF and LVM for single and multiple time-points on the same and different scanners.Results: For EF, the coefficient of repeatability (CoR) increased as different observers, multiple time-points, and different scanners were introduced. The CoR ranged from 2.8% (intraobserver measurements, single time-point, same scanner) to 10.0% (interobserver measurements, different timepoints, different scanners). For LVM, intraobserver CoR parameters were consistently smaller than interobserver values. The CoR ranged from 7.8 g (intraobserver measurements, single time-point, same scanner) to 39.5 g (interobserver measurements, different time-points, different scanners).Conclusion: Reproducible EF data can be obtained at single or multiple time-points. using different scanners. However, LUM is notably susceptible to interobserver variation, and this should be carefully considered if similar evaluations are planned as part of multicenter or longitudinal investigations.

KW - cardiac MRI

KW - reproducibility

KW - multicenter

KW - left ventricular mass

KW - ejection fraction

KW - CARDIOVASCULAR MAGNETIC-RESONANCE

KW - INTERSTUDY REPRODUCIBILITY

KW - BREATH-HOLD

KW - 2-DIMENSIONAL ECHOCARDIOGRAPHY

KW - HEART-FAILURE

KW - TRUE-FISP

KW - MASS

KW - CINE

KW - VOLUMES

KW - FLASH

U2 - 10.1002/jmri.21401

DO - 10.1002/jmri.21401

M3 - Article

C2 - 18666157

SN - 1053-1807

VL - 28

SP - 359

EP - 365

JO - Journal of Magnetic Resonance Imaging

JF - Journal of Magnetic Resonance Imaging

IS - 2

ER -