Complete response in a melanoma patient treated with imatinib

M. C. Brown, R. J. Casasola

    Research output: Contribution to journalArticle

    8 Citations (Scopus)

    Abstract

    Background: Imatinib therapy has been successful in gastrointestinal stromal tumours containing mutation of the KIT gene. However, there are few reported cases of successful imatinib therapy in patients with melanoma containing KIT gene mutation or c-kit protein expression.</p><p>Methods and results: A 52-year-old man developed metastatic melanoma from a primary melanoma in the left side of the nasopharynx. The tumour was positive for c-kit protein, and there was a KIT mutation in exon 11. He was treated with imatinib. A follow-up scan one year later showed a complete response. Treatment targeting the biological characteristics of melanoma proved successful in this patient.</p>
    Original languageEnglish
    Pages (from-to)638-640
    Number of pages3
    JournalJournal of Laryngology and Otology
    Volume126
    Issue number6
    DOIs
    Publication statusPublished - Jun 2012

    Cite this

    Brown, M. C. ; Casasola, R. J. / Complete response in a melanoma patient treated with imatinib. In: Journal of Laryngology and Otology. 2012 ; Vol. 126, No. 6. pp. 638-640.
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    Complete response in a melanoma patient treated with imatinib. / Brown, M. C.; Casasola, R. J.

    In: Journal of Laryngology and Otology, Vol. 126, No. 6, 06.2012, p. 638-640.

    Research output: Contribution to journalArticle

    TY - JOUR

    T1 - Complete response in a melanoma patient treated with imatinib

    AU - Brown, M. C.

    AU - Casasola, R. J.

    PY - 2012/6

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    N2 - Background: Imatinib therapy has been successful in gastrointestinal stromal tumours containing mutation of the KIT gene. However, there are few reported cases of successful imatinib therapy in patients with melanoma containing KIT gene mutation or c-kit protein expression.Methods and results: A 52-year-old man developed metastatic melanoma from a primary melanoma in the left side of the nasopharynx. The tumour was positive for c-kit protein, and there was a KIT mutation in exon 11. He was treated with imatinib. A follow-up scan one year later showed a complete response. Treatment targeting the biological characteristics of melanoma proved successful in this patient.

    AB - Background: Imatinib therapy has been successful in gastrointestinal stromal tumours containing mutation of the KIT gene. However, there are few reported cases of successful imatinib therapy in patients with melanoma containing KIT gene mutation or c-kit protein expression.Methods and results: A 52-year-old man developed metastatic melanoma from a primary melanoma in the left side of the nasopharynx. The tumour was positive for c-kit protein, and there was a KIT mutation in exon 11. He was treated with imatinib. A follow-up scan one year later showed a complete response. Treatment targeting the biological characteristics of melanoma proved successful in this patient.

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    DO - 10.1017/S0022215112000527

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    EP - 640

    JO - Journal of Laryngology and Otology

    JF - Journal of Laryngology and Otology

    SN - 0022-2151

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