Complex regulation of thyroid hormone action: multiple opportunities for pharmacological intervention

Yun-Bo Shi; James W. A. Ritchie; Peter M. Taylor

doi:10.1016/S0163-7258(02)00219-X

Complex regulation of thyroid hormone action: multiple opportunities for pharmacological intervention

Yun-Bo Shi
, James W. A. Ritchie
, Peter M. Taylor

Research output: Contribution to journal › Review article › peer-review

31 Citations (Scopus)

Abstract

The thyroid hormone (TH; 3,3',5,5'-tetra-iodothyronine and 3,3',5-triiodothyronine) regulates growth, development, and critical metabolic functions. Thyroid diseases are among the most prevalent group of metabolic disorders in the Western world. TH exert's effects through complex biological pathways, which offer a wealth of opportunities to pharmacologically intervene in TH signalling at numerous steps. These include biosynthesis, cell-specific uptake or export (involving L-type amino acid transporter, organic anion transporter, organic cation transporter, or multidrug resistance transporter), as well as nuclear targeting and actions (the latter including TH receptor binding and histone acetylation/deacetylation). Such processes represent potentially important pharmacological targets for the design of novel or improved therapies for TH disorders, obesity, and cardiovascular diseases. (C) 2002 Elsevier Science Inc. All rights reserved.

Original language	English
Pages (from-to)	235-251
Number of pages	17
Journal	Pharmacology & Therapeutics
Volume	94
Issue number	3
DOIs	https://doi.org/10.1016/S0163-7258(02)00219-X
Publication status	Published - 2002

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SDG 3 Good Health and Well-being

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10.1016/S0163-7258(02)00219-X

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title = "Complex regulation of thyroid hormone action: multiple opportunities for pharmacological intervention",

abstract = "The thyroid hormone (TH; 3,3',5,5'-tetra-iodothyronine and 3,3',5-triiodothyronine) regulates growth, development, and critical metabolic functions. Thyroid diseases are among the most prevalent group of metabolic disorders in the Western world. TH exert's effects through complex biological pathways, which offer a wealth of opportunities to pharmacologically intervene in TH signalling at numerous steps. These include biosynthesis, cell-specific uptake or export (involving L-type amino acid transporter, organic anion transporter, organic cation transporter, or multidrug resistance transporter), as well as nuclear targeting and actions (the latter including TH receptor binding and histone acetylation/deacetylation). Such processes represent potentially important pharmacological targets for the design of novel or improved therapies for TH disorders, obesity, and cardiovascular diseases. (C) 2002 Elsevier Science Inc. All rights reserved.",

author = "Yun-Bo Shi and Ritchie, \{James W. A.\} and Taylor, \{Peter M.\}",

year = "2002",

doi = "10.1016/S0163-7258(02)00219-X",

language = "English",

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pages = "235--251",

journal = "Pharmacology \& Therapeutics",

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T1 - Complex regulation of thyroid hormone action

T2 - multiple opportunities for pharmacological intervention

AU - Shi, Yun-Bo

AU - Ritchie, James W. A.

AU - Taylor, Peter M.

PY - 2002

Y1 - 2002

N2 - The thyroid hormone (TH; 3,3',5,5'-tetra-iodothyronine and 3,3',5-triiodothyronine) regulates growth, development, and critical metabolic functions. Thyroid diseases are among the most prevalent group of metabolic disorders in the Western world. TH exert's effects through complex biological pathways, which offer a wealth of opportunities to pharmacologically intervene in TH signalling at numerous steps. These include biosynthesis, cell-specific uptake or export (involving L-type amino acid transporter, organic anion transporter, organic cation transporter, or multidrug resistance transporter), as well as nuclear targeting and actions (the latter including TH receptor binding and histone acetylation/deacetylation). Such processes represent potentially important pharmacological targets for the design of novel or improved therapies for TH disorders, obesity, and cardiovascular diseases. (C) 2002 Elsevier Science Inc. All rights reserved.

AB - The thyroid hormone (TH; 3,3',5,5'-tetra-iodothyronine and 3,3',5-triiodothyronine) regulates growth, development, and critical metabolic functions. Thyroid diseases are among the most prevalent group of metabolic disorders in the Western world. TH exert's effects through complex biological pathways, which offer a wealth of opportunities to pharmacologically intervene in TH signalling at numerous steps. These include biosynthesis, cell-specific uptake or export (involving L-type amino acid transporter, organic anion transporter, organic cation transporter, or multidrug resistance transporter), as well as nuclear targeting and actions (the latter including TH receptor binding and histone acetylation/deacetylation). Such processes represent potentially important pharmacological targets for the design of novel or improved therapies for TH disorders, obesity, and cardiovascular diseases. (C) 2002 Elsevier Science Inc. All rights reserved.

U2 - 10.1016/S0163-7258(02)00219-X

DO - 10.1016/S0163-7258(02)00219-X

M3 - Review article

SN - 0163-7258

VL - 94

SP - 235

EP - 251

JO - Pharmacology & Therapeutics

JF - Pharmacology & Therapeutics

IS - 3

ER -

Complex regulation of thyroid hormone action: multiple opportunities for pharmacological intervention

Abstract

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