Complex renal cysts (Bosniak ≥IIF): Outcomes in a population-based cohort study

James Lucocq (Lead / Corresponding author), Sanjay Pillai, Richard Oparka, Ghulam Nabi

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Abstract

There is emerging evidence to suggest that con-current medical conditions influence the outcome of cancers, irrespective of therapy offered. The prevalence and impact of co-morbidities on the survival outcome of complex renal cystic masses in not known. The objective was to study complex renal cysts (Bosniak ≥IIF ) and assess the overall and renal cancer-specific survival in a population-based database including impact of con-current morbidities. The Tayside Urological Cancer Network (TUCAN) database covering a stable population of more than 416,090 inhabitants in a defined geographical area identified 452 complex renal cysts in 415 patients between 2009 and 2019. Each patient was tracked and followed up using a unique identifier and deterministic linkage methodology. The last date of follow-up including cause of death was determined. Co-morbidities were recorded from primary care referrals. Renal cancer-specific mortality was 1.7% at a median follow-up of 76.0 months; however, overall survival was poor, particularly in patients ≥ 70 years of age and with ≥ 2 significant co-morbid conditions (p < 0.0001). A total of 38.3% of the cohort showed con-current morbidities. Age and co-morbidities were significant risk factors for overall survival in patients with complex renal cystic disease and a careful assessment should be made to recommend surgical intervention in the elderly population, in particular in those with other health-related conditions.
Original languageEnglish
Article number2549
Pages (from-to)1-12
Number of pages12
JournalCancers
Volume12
Issue number9
Early online date8 Sep 2020
DOIs
Publication statusPublished - Sep 2020

Keywords

  • Kidney Neoplasms
  • Nephrectomy
  • Survival Analysis

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