TY - JOUR
T1 - Compulsivity in opioid dependence
AU - Tolomeo, Serenella
AU - Matthews, Keith
AU - Steele, J. Douglas
AU - Baldacchino, Alex
N1 - Funding/Support: This study was part funded by an unrestricted educational grant provided by Schering-Plough and a grant by an Anonymous Trust. Study support was also provided by the Scottish Mental Health Research Network. The funding sources had no role in the design, conduct of the study and interpretation of the data. ST has received funding from Merck Serono and Lundbeck, JDS has received research funding via an honorarium associated with a lecture from Wyeth and an unrestricted educational grant from Schering-Plough, KM has chaired advisory boards for studies of Deep Brain Stimulation for Obsessive-Compulsive Disorder sponsored by Medtronic. He has received educational grants from Cyberonics Inc. and Schering Plough, and he has received research project funding from Schering-Plough, Merck Serono, and Indivior and also from St Jude Medical for a multi-centre clinical trial of Deep Brain Stimulation for depression. He has received travel and accommodation support to attend meetings from Medtronic and St Jude Medical. AB has received educational grants from Schering Plough and he has received research project funding from ScheringPlough, Merck Serono and Indivior.
PY - 2018/2/2
Y1 - 2018/2/2
N2 - Objective: This study aimed to investigate the relationship between compulsivity versus impulsivity and structural MRI abnormalities in opioid dependence.Method: We recruited 146 participants: i) patients with a history of opioid dependence due to chronic heroin use (n = 24), ii) heroin users stabilised on methadone maintenance treatment (n = 48), iii) abstinent participants with a history of opioid dependence due to heroin use (n = 24) and iv) healthy controls (n = 50). Compulsivity was measured using Intra/Extra-Dimensional (IED) Task and impulsivity was measured using the Cambridge Gambling Task (CGT). Structural Magnetic Resonance Imaging (MRI) data were also obtained.Results: As hypothesised, compulsivity was negatively associated with impulsivity (p < 0.02). Testing for the neural substrates of compulsivity versus impulsivity, we found a higher compulsivity/impulsivity ratio associated with significantly decreased white matter adjacent to the nucleus accumbens, bed nucleus of stria terminalis and rostral cingulate in the abstinent group, compared to the other opioid dependent groups. In addition, self-reported duration of opioid exposure correlated negatively with bilateral globus pallidus grey matter reductions.Conclusion: Our findings are consistent with Volkow & Koob's addiction models and underline the important role of compulsivity versus impulsivity in opioid dependence. Our results have implications for the treatment of opioid dependence supporting the assertion of different behavioural and biological phenotypes in the opioid dependence and abstinence syndromes.
AB - Objective: This study aimed to investigate the relationship between compulsivity versus impulsivity and structural MRI abnormalities in opioid dependence.Method: We recruited 146 participants: i) patients with a history of opioid dependence due to chronic heroin use (n = 24), ii) heroin users stabilised on methadone maintenance treatment (n = 48), iii) abstinent participants with a history of opioid dependence due to heroin use (n = 24) and iv) healthy controls (n = 50). Compulsivity was measured using Intra/Extra-Dimensional (IED) Task and impulsivity was measured using the Cambridge Gambling Task (CGT). Structural Magnetic Resonance Imaging (MRI) data were also obtained.Results: As hypothesised, compulsivity was negatively associated with impulsivity (p < 0.02). Testing for the neural substrates of compulsivity versus impulsivity, we found a higher compulsivity/impulsivity ratio associated with significantly decreased white matter adjacent to the nucleus accumbens, bed nucleus of stria terminalis and rostral cingulate in the abstinent group, compared to the other opioid dependent groups. In addition, self-reported duration of opioid exposure correlated negatively with bilateral globus pallidus grey matter reductions.Conclusion: Our findings are consistent with Volkow & Koob's addiction models and underline the important role of compulsivity versus impulsivity in opioid dependence. Our results have implications for the treatment of opioid dependence supporting the assertion of different behavioural and biological phenotypes in the opioid dependence and abstinence syndromes.
KW - Adult
KW - Brain/diagnostic imaging
KW - Chronic Disease
KW - Compulsive Behavior/diagnostic imaging
KW - Cross-Sectional Studies
KW - Humans
KW - Image Processing, Computer-Assisted
KW - Impulsive Behavior/drug effects
KW - Magnetic Resonance Imaging
KW - Male
KW - Neuropsychological Tests
KW - Opioid-Related Disorders/diagnostic imaging
UR - http://www.scopus.com/inward/record.url?scp=85029747826&partnerID=8YFLogxK
U2 - 10.1016/j.pnpbp.2017.09.007
DO - 10.1016/j.pnpbp.2017.09.007
M3 - Article
C2 - 28918267
VL - 81
SP - 333
EP - 339
JO - Progress in Neuro-Psychopharmacology and Biological Psychiatry
JF - Progress in Neuro-Psychopharmacology and Biological Psychiatry
SN - 0278-5846
ER -
