TY - JOUR
T1 - Computed tomography assessment of response to therapy
T2 - tumor volume change measurement, truth data, and error
AU - McNitt-Gray, Michael F.
AU - Bidaut, Luc M.
AU - Armato III, Samuel G.
AU - Meyer, Charles R.
AU - Gavrielides, Marios A.
AU - Fenimore, Charles
AU - McLennan, Geoffrey
AU - Petrick, Nicholas
AU - Zhao, Binsheng
AU - Reeves, Anthony P.
AU - Beichel, Reinhard
AU - Kim, Hyun-Jung (Grace)
AU - Kinnard, Lisa
PY - 2009/12
Y1 - 2009/12
N2 - RATIONALE AND OBJECTIVES: This article describes issues and methods that are specific to the measurement of change in tumor volume as measured from computed tomographic (CT) images and how these would relate to the establishment of CT tumor volumetrics as a biomarker of patient response to therapy. The primary focus is on the measurement of lung tumors, but the approach should be generalizable to other anatomic regions. MATERIALS AND METHODS: The first issues addressed are the various sources of bias and variance in the measurement of tumor volumes, which are discussed in the context of measurement variation and its impact on the early detection of response to therapy. RESULTS AND RESOURCES: Research that seeks to identify the magnitude of some of these sources of error is ongoing, and several of these efforts are described herein. In addition, several resources for these investigations are being made available through the National Institutes of Health-funded Reference Image Database to Evaluate Response to therapy in cancer project, and these are described as well. Other measures derived from CT image data that might be predictive of patient response are described briefly, as well as the additional issues that each of these metrics may encounter in real-life applications. CONCLUSIONS: The article concludes with a brief discussion of moving from the assessment of measurement variation to the steps necessary to establish the efficacy of a metric as a biomarker for response.
AB - RATIONALE AND OBJECTIVES: This article describes issues and methods that are specific to the measurement of change in tumor volume as measured from computed tomographic (CT) images and how these would relate to the establishment of CT tumor volumetrics as a biomarker of patient response to therapy. The primary focus is on the measurement of lung tumors, but the approach should be generalizable to other anatomic regions. MATERIALS AND METHODS: The first issues addressed are the various sources of bias and variance in the measurement of tumor volumes, which are discussed in the context of measurement variation and its impact on the early detection of response to therapy. RESULTS AND RESOURCES: Research that seeks to identify the magnitude of some of these sources of error is ongoing, and several of these efforts are described herein. In addition, several resources for these investigations are being made available through the National Institutes of Health-funded Reference Image Database to Evaluate Response to therapy in cancer project, and these are described as well. Other measures derived from CT image data that might be predictive of patient response are described briefly, as well as the additional issues that each of these metrics may encounter in real-life applications. CONCLUSIONS: The article concludes with a brief discussion of moving from the assessment of measurement variation to the steps necessary to establish the efficacy of a metric as a biomarker for response.
UR - http://www.scopus.com/inward/record.url?scp=77953437877&partnerID=8YFLogxK
U2 - 10.1593/tlo.09226
DO - 10.1593/tlo.09226
M3 - Article
AN - SCOPUS:77953437877
SN - 1944-7124
VL - 2
SP - 216
EP - 222
JO - Translational Oncology
JF - Translational Oncology
IS - 4
ER -
