Concentration-Dependent Changes of PCB Patterns in Fish-Eating Mammals: Structural Evidence for Induction of Cytochrome P450

TY - JOUR

T1 - Concentration-Dependent Changes of PCB Patterns in Fish-Eating Mammals

T2 - Structural Evidence for Induction of Cytochrome P450

AU - Boon, J. P.

AU - van der Meer, J.

AU - Allchin, C. R.

AU - Law, R. J.

AU - Klungsøyr, J.

AU - Leonards, P. E. G.

AU - Spliid, H.

AU - Storr-Hansen, E.

AU - Mckenzie, C.

AU - Wells, D. E.

N1 - No funding info

PY - 1997/10

Y1 - 1997/10

N2 - Data sets on CB concentrations in fish-eating mammals from five laboratories were combined to test and refine a pharmacokinetic model. Clear differences in PCB patterns were observed between species. The ability to metabolize chlorobiphenyl (CB) congeners with vicinal H-atoms only in the ortho- and meta-positions and with one ortho-chlorine substituent generally increased in the order otter < cetaceans (harbor porpoise, common dolphin) < phocid seals (harbor and grey seal), but the metabolism of congeners with vicinal H-atoms in the meta- and para-positions and with two ortho-chlorines increased in the order cetaceans < seals < otter. Both categories of congeners are probably metabolized by different families of cytochrome P450 (1A and 2B) of which levels apparently differed between the cetaceans, the pinnipeds, and the otter. Within-species CB patterns differed in a concentration-dependent manner. The induction of cytochrome P450 enzymes offers the most likely explanation for this phenomenon, but starvation could have a similar effect on occasion.

AB - Data sets on CB concentrations in fish-eating mammals from five laboratories were combined to test and refine a pharmacokinetic model. Clear differences in PCB patterns were observed between species. The ability to metabolize chlorobiphenyl (CB) congeners with vicinal H-atoms only in the ortho- and meta-positions and with one ortho-chlorine substituent generally increased in the order otter < cetaceans (harbor porpoise, common dolphin) < phocid seals (harbor and grey seal), but the metabolism of congeners with vicinal H-atoms in the meta- and para-positions and with two ortho-chlorines increased in the order cetaceans < seals < otter. Both categories of congeners are probably metabolized by different families of cytochrome P450 (1A and 2B) of which levels apparently differed between the cetaceans, the pinnipeds, and the otter. Within-species CB patterns differed in a concentration-dependent manner. The induction of cytochrome P450 enzymes offers the most likely explanation for this phenomenon, but starvation could have a similar effect on occasion.

UR - https://www.scopus.com/pages/publications/0030671084

U2 - 10.1007/s002449900257

DO - 10.1007/s002449900257

M3 - Article

C2 - 9353208

AN - SCOPUS:0030671084

SN - 0090-4341

VL - 33

SP - 298

EP - 311

JO - Archives of Environmental Contamination and Toxicology

JF - Archives of Environmental Contamination and Toxicology

IS - 3

ER -