Conditional Activin Receptor Type 1B (Acvr1b) Knockout Mice reveal hair loss abnormality

Wanglong Qiu, Xiaojun Li, Hongyan Tang, Alicia S. Huang, Andrey A. Panteleyev, David M. Owens, Gloria H. Su

    Research output: Contribution to journalArticle

    29 Citations (Scopus)

    Abstract

    The in vivo functions of the activin A receptor type 1b (Acvr1b) have been difficult to study because Acvr1b(-/-) mice die during embryogenesis. To investigate the roles of Acvr1b in the epithelial tissues, we created mice with a conditional disruption of Acvr1b (Acvr1b(flox/flox)) and crossed them with K14-Cre mice. Acvr1(bflox/flox); K14-Cre mice displayed various degrees of hairlessness at postnatal day 5, and the phenotype is exacerbated by age. Histological analyses showed that those hair follicles that developed during morphogenesis were later disrupted by delays in hair cycle reentry. Failure in cycling of the hair follicles and regrowth of the hair shaft and the inner root sheath resulted in subsequent severe hair loss. Apart from previous reports of other members of the transforming growth factor-beta/activin/bone morphogenic protein pathways, we demonstrate a specialized role for Acvr1b in hair cycling in addition to hair follicle development. Acvr1b(flox/flox); K14-Cre mice also had a thicker epidermis than did wild-type mice, which resulted from persistent proliferation of skin epithelial cells; however, no tumor formation was observed by 18 months of age. Our analysis of this Acvr1b knockout mouse line provides direct genetic evidence that Acvr1b signaling is required for both hair follicle development and cycling.

    Original languageEnglish
    Pages (from-to)1067-1076
    Number of pages10
    JournalJournal of Investigative Dermatology
    Volume131
    Issue number5
    DOIs
    Publication statusPublished - May 2011

    Keywords

    • BETA TYPE-I
    • EPIDERMAL MORPHOGENESIS
    • FOLLICLE DEVELOPMENT
    • TOOTH DEVELOPMENT
    • BREAST-CANCER
    • WOUND REPAIR
    • STEM-CELLS
    • MOUSE
    • SKIN
    • GENE

    Cite this

    Qiu, W., Li, X., Tang, H., Huang, A. S., Panteleyev, A. A., Owens, D. M., & Su, G. H. (2011). Conditional Activin Receptor Type 1B (Acvr1b) Knockout Mice reveal hair loss abnormality. Journal of Investigative Dermatology, 131(5), 1067-1076. https://doi.org/10.1038/jid.2010.400