Plasticity of mature hippocampal CA1 synapses is dependent onl-a-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA) receptors containing the glutamate receptor A (GluR-A) subunit. In GluR-A–deficient mice, plasticity could be restored by controlled expression of green fluorescent protein (GFP)–tagged GluR-A, which contributes to channel formation and displayed the developmental redistribution of AMPA receptors in CA1 pyramidal neurons. Long-term potentiation (LTP) induced by pairing or tetanic stimulation was rescued in adult GluR-A–/– mice when GFPGluR-A expression was constitutive or induced in already fully developed pyramidal cells. This shows that GluR-A–independent forms of synaptic plasticity can mediate the establishment of mature hippocampal circuits that are prebuilt to express GluR-A–dependent LTP.
Mack, V., Burnashev, N., Kaiser, K. M. M., Rozov, A., Jensen, V., Hvalby, O., Seeburg, P. H., Sakmann, B., & Sprengel, R. (2001). Conditional restoration of hippocampal synaptic potentiation in GluR-A-deficient mice. Science, 292(5526), 2501-2504. https://doi.org/10.1126/science.1059365