Conditional restoration of hippocampal synaptic potentiation in GluR-A-deficient mice

Volker Mack, Nail Burnashev, Katharina M. M. Kaiser, Andrei Rozov, Vidar Jensen, Ovind Hvalby, Peter H. Seeburg, Bert Sakmann, Rolf Sprengel

    Research output: Contribution to journalArticlepeer-review

    99 Citations (Scopus)


    Plasticity of mature hippocampal CA1 synapses is dependent onl-a-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA) receptors containing the glutamate receptor A (GluR-A) subunit. In GluR-A–deficient mice, plasticity could be restored by controlled expression of green fluorescent protein (GFP)–tagged GluR-A, which contributes to channel formation and displayed the developmental redistribution of AMPA receptors in CA1 pyramidal neurons. Long-term potentiation (LTP) induced by pairing or tetanic stimulation was rescued in adult GluR-A–/– mice when GFPGluR-A expression was constitutive or induced in already fully developed pyramidal cells. This shows that GluR-A–independent forms of synaptic plasticity can mediate the establishment of mature hippocampal circuits that are prebuilt to express GluR-A–dependent LTP.
    Original languageEnglish
    Pages (from-to)2501-2504
    Number of pages4
    Issue number5526
    Publication statusPublished - Jun 2001


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