Conditional restoration of hippocampal synaptic potentiation in GluR-A-deficient mice

Volker Mack; Nail Burnashev; Katharina M. M. Kaiser; Andrei Rozov; Vidar Jensen; Ovind Hvalby; Peter H. Seeburg; Bert Sakmann; Rolf Sprengel

doi:10.1126/science.1059365

Conditional restoration of hippocampal synaptic potentiation in GluR-A-deficient mice

Volker Mack
, Nail Burnashev
, Katharina M. M. Kaiser
, Andrei Rozov
, Vidar Jensen
, Ovind Hvalby
, Peter H. Seeburg
, Bert Sakmann
, Rolf Sprengel

Research output: Contribution to journal › Article › peer-review

103 Citations (Scopus)

Abstract

Plasticity of mature hippocampal CA1 synapses is dependent onl-a-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA) receptors containing the glutamate receptor A (GluR-A) subunit. In GluR-A–deficient mice, plasticity could be restored by controlled expression of green fluorescent protein (GFP)–tagged GluR-A, which contributes to channel formation and displayed the developmental redistribution of AMPA receptors in CA1 pyramidal neurons. Long-term potentiation (LTP) induced by pairing or tetanic stimulation was rescued in adult GluR-A–/– mice when GFPGluR-A expression was constitutive or induced in already fully developed pyramidal cells. This shows that GluR-A–independent forms of synaptic plasticity can mediate the establishment of mature hippocampal circuits that are prebuilt to express GluR-A–dependent LTP.

Original language	English
Pages (from-to)	2501-2504
Number of pages	4
Journal	Science
Volume	292
Issue number	5526
DOIs	https://doi.org/10.1126/science.1059365
Publication status	Published - Jun 2001

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title = "Conditional restoration of hippocampal synaptic potentiation in GluR-A-deficient mice",

abstract = "Plasticity of mature hippocampal CA1 synapses is dependent onl-a-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA) receptors containing the glutamate receptor A (GluR-A) subunit. In GluR-A{\textendash}deficient mice, plasticity could be restored by controlled expression of green fluorescent protein (GFP){\textendash}tagged GluR-A, which contributes to channel formation and displayed the developmental redistribution of AMPA receptors in CA1 pyramidal neurons. Long-term potentiation (LTP) induced by pairing or tetanic stimulation was rescued in adult GluR-A{\textendash}/{\textendash} mice when GFPGluR-A expression was constitutive or induced in already fully developed pyramidal cells. This shows that GluR-A{\textendash}independent forms of synaptic plasticity can mediate the establishment of mature hippocampal circuits that are prebuilt to express GluR-A{\textendash}dependent LTP.",

author = "Volker Mack and Nail Burnashev and Kaiser, \{Katharina M. M.\} and Andrei Rozov and Vidar Jensen and Ovind Hvalby and Seeburg, \{Peter H.\} and Bert Sakmann and Rolf Sprengel",

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TY - JOUR

T1 - Conditional restoration of hippocampal synaptic potentiation in GluR-A-deficient mice

AU - Mack, Volker

AU - Burnashev, Nail

AU - Kaiser, Katharina M. M.

AU - Rozov, Andrei

AU - Jensen, Vidar

AU - Hvalby, Ovind

AU - Seeburg, Peter H.

AU - Sakmann, Bert

AU - Sprengel, Rolf

N1 - dc.publisher: American Association for the Advancement of Science

PY - 2001/6

Y1 - 2001/6

N2 - Plasticity of mature hippocampal CA1 synapses is dependent onl-a-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA) receptors containing the glutamate receptor A (GluR-A) subunit. In GluR-A–deficient mice, plasticity could be restored by controlled expression of green fluorescent protein (GFP)–tagged GluR-A, which contributes to channel formation and displayed the developmental redistribution of AMPA receptors in CA1 pyramidal neurons. Long-term potentiation (LTP) induced by pairing or tetanic stimulation was rescued in adult GluR-A–/– mice when GFPGluR-A expression was constitutive or induced in already fully developed pyramidal cells. This shows that GluR-A–independent forms of synaptic plasticity can mediate the establishment of mature hippocampal circuits that are prebuilt to express GluR-A–dependent LTP.

AB - Plasticity of mature hippocampal CA1 synapses is dependent onl-a-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA) receptors containing the glutamate receptor A (GluR-A) subunit. In GluR-A–deficient mice, plasticity could be restored by controlled expression of green fluorescent protein (GFP)–tagged GluR-A, which contributes to channel formation and displayed the developmental redistribution of AMPA receptors in CA1 pyramidal neurons. Long-term potentiation (LTP) induced by pairing or tetanic stimulation was rescued in adult GluR-A–/– mice when GFPGluR-A expression was constitutive or induced in already fully developed pyramidal cells. This shows that GluR-A–independent forms of synaptic plasticity can mediate the establishment of mature hippocampal circuits that are prebuilt to express GluR-A–dependent LTP.

U2 - 10.1126/science.1059365

DO - 10.1126/science.1059365

M3 - Article

C2 - 11431570

SN - 0036-8075

VL - 292

SP - 2501

EP - 2504

JO - Science

JF - Science

IS - 5526

ER -

Conditional restoration of hippocampal synaptic potentiation in GluR-A-deficient mice

Abstract

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