Conformational control of cofactors in nature - functional tetrapyrrole conformations in the photosynthetic reaction centers of purple bacteria.

TY - JOUR

T1 - Conformational control of cofactors in nature - functional tetrapyrrole conformations in the photosynthetic reaction centers of purple bacteria.

AU - MacGowan, Stuart A.

AU - Senge, Mathias O.

PY - 2011/11/14

Y1 - 2011/11/14

N2 - Chemically identical tetrapyrrole cofactors such as hemes and chlorophylls participate in functionally diverse biological roles. An analysis of the available protein structural data for the bacteriochlorophylls in the photosynthetic reaction center gives statistically reliable evidence of the hypothesis that the protein induced cofactor conformation is a modulator of the bio-molecular function of each reaction center. The results serve as a general model to illustrate conformational control of tetrapyrrole cofactors in other proteins.

AB - Chemically identical tetrapyrrole cofactors such as hemes and chlorophylls participate in functionally diverse biological roles. An analysis of the available protein structural data for the bacteriochlorophylls in the photosynthetic reaction center gives statistically reliable evidence of the hypothesis that the protein induced cofactor conformation is a modulator of the bio-molecular function of each reaction center. The results serve as a general model to illustrate conformational control of tetrapyrrole cofactors in other proteins.

UR - http://europepmc.org/abstract/med/21956457

U2 - 10.1039/c1cc14686f

DO - 10.1039/c1cc14686f

M3 - Article

C2 - 21956457

SN - 1359-7345

VL - 47

SP - 11621

EP - 11623

JO - Chemical Communications

JF - Chemical Communications

IS - 42

ER -