Congenital familial subglottic stenosis: A case series and review of literature

J. Manickavasagam (Lead / Corresponding author), S. Yapa, N. D. Bateman, M. S. Thevasagayam

    Research output: Contribution to journalArticlepeer-review

    4 Citations (Scopus)

    Abstract

    Subglottic stenosis is a narrowing of the endolarynx and maybe classified as congenital (primary) or acquired (secondary). Congenital stenosis maybe caused by a small cricoid cartilage, thick submucosa or other laryngeal abnormalities and remains a well-known cause of stridor in infancy. It occurs sporadically and familial occurrence is rare. Our case series identifies three children with congenital subglottic stenosis born to consanguineous parents. Congenital subglottic stenosis in siblings of unrelated parents has been previously reported, but not in consanguineous parents indicating a strong genetic link. We recommend further genetic research to assess the mode of possible heritage in this disease.

    Original languageEnglish
    Pages (from-to)359-362
    Number of pages4
    JournalInternational Journal of Pediatric Otorhinolaryngology
    Volume78
    Issue number2
    Early online date13 Nov 2013
    DOIs
    Publication statusPublished - Feb 2014

    Keywords

    • Congenital
    • Familial
    • Stenosis
    • Subglottic

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