Conscious Sedation and Analgesia for Oocyte Retrieval

Jennifer M. Ulyatt, Sarah Martins Da Silva

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)peer-review


Oocyte retrieval is a necessary part of IVF treatment. Conscious sedation using a combination of midazolam for anxiolysis, propofol for sedation and alfentanil for analgesia is the commonest approach used to provide pain relief for oocyte retrieval. This chapter presents a practical overview of patient sedation for assisted conception. Recommendations are based on the framework for safe sedation practice set out by the Royal College of Anaesthetists (UK) and include pre-operative assessment, patient preparation and fasting, sedation and analgesia medication, monitoring and recovery. While conscious sedation is commonly delivered by medical practitioners, nurse-led sedation is increasingly being adopted in the fertility sector as it is both appropriate and safe with certain caveats. We also describe the development of a nurse-led sedation service within a hospital-based fertility clinic (Ninewells Assisted Conception Unit, NHS Tayside, UK), and include examples of documentation (pre-anaesthetic chart) and drug protocols developed for effective and safe practice.
Original languageEnglish
Title of host publicationManual of Oocyte Retrieval and Preparation in Human Assisted Reproduction
EditorsRachel Cutting, Mostafa Metwally
Place of PublicationCambridge
PublisherCambridge University Press
Number of pages13
ISBN (Electronic)9781108891646
ISBN (Print)9781108799690
Publication statusPublished - 2022


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