Contraceptive potential of antibodies to the zona pellucida

C. J. Henderson, M. J. Hulme, R. J. Aitken

    Research output: Contribution to journalArticlepeer-review

    48 Citations (Scopus)


    The notion of a contraceptive vaccine based on gamete-specific surface antigens was first proposed over a decade ago, as the result of in-vitro and in-vivo studies, and in recent years has been the subject of intensive research. In particular, the zona pellucida has attracted much attention as a potential target for immunological intervention in the fertilization process. Such is the rapidly-expanding nature of research into the biochemical and biological characterization of this structure, that a review of the implications for the development of a contraceptive vaccine seems timely.
    Original languageEnglish
    Pages (from-to)325-343
    Number of pages19
    JournalJournal of Reproduction and Fertility
    Issue number1
    Publication statusPublished - 1 May 1988


    • Zona pellucida
    • Contraceptive vaccine
    • Antibodies


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