Contraceptive potential of antibodies to the zona pellucida

TY - JOUR

T1 - Contraceptive potential of antibodies to the zona pellucida

AU - Henderson, C. J.

AU - Hulme, M. J.

AU - Aitken, R. J.

PY - 1988/5/1

Y1 - 1988/5/1

N2 - The notion of a contraceptive vaccine based on gamete-specific surface antigens was first proposed over a decade ago, as the result of in-vitro and in-vivo studies, and in recent years has been the subject of intensive research. In particular, the zona pellucida has attracted much attention as a potential target for immunological intervention in the fertilization process. Such is the rapidly-expanding nature of research into the biochemical and biological characterization of this structure, that a review of the implications for the development of a contraceptive vaccine seems timely.

AB - The notion of a contraceptive vaccine based on gamete-specific surface antigens was first proposed over a decade ago, as the result of in-vitro and in-vivo studies, and in recent years has been the subject of intensive research. In particular, the zona pellucida has attracted much attention as a potential target for immunological intervention in the fertilization process. Such is the rapidly-expanding nature of research into the biochemical and biological characterization of this structure, that a review of the implications for the development of a contraceptive vaccine seems timely.

KW - Zona pellucida

KW - Contraceptive vaccine

KW - Antibodies

U2 - 10.1530/jrf.0.0830325

DO - 10.1530/jrf.0.0830325

M3 - Article

SN - 0022-4251

VL - 83

SP - 325

EP - 343

JO - Journal of Reproduction and Fertility

JF - Journal of Reproduction and Fertility

IS - 1

ER -