Control of pre-T cell proliferation and differentiation by the GTPase Rac-1

TY - JOUR

T1 - Control of pre-T cell proliferation and differentiation by the GTPase Rac-1

AU - Gomez, Manuel

AU - Tybulewicz, Victor

AU - Cantrell, Doreen A.

PY - 2000/10

Y1 - 2000/10

N2 - The GTPase Rac-1 has the potential for pleiotropic functions due to its ability to interact with multiple effectors. Here, activation of Rac-1 is shown to potently regulate pre-T cell differentiation and proliferation at the point of T cell antigen receptor (TCR) β selection. An activated Rac-1 effector domain mutant that restricts signaling to particular actions on actin dynamics can drive pre-T cell differentiation. Rac-1 activation cannot fully substitute for the pre-TCR complex but can fully correct defects in pre-T cell development in mice lacking the adapter molecule Vav-1. The present study identifies the subset of Rac-1 responses that mediate Vav-1 action as critical regulators of TCRβ selection.

AB - The GTPase Rac-1 has the potential for pleiotropic functions due to its ability to interact with multiple effectors. Here, activation of Rac-1 is shown to potently regulate pre-T cell differentiation and proliferation at the point of T cell antigen receptor (TCR) β selection. An activated Rac-1 effector domain mutant that restricts signaling to particular actions on actin dynamics can drive pre-T cell differentiation. Rac-1 activation cannot fully substitute for the pre-TCR complex but can fully correct defects in pre-T cell development in mice lacking the adapter molecule Vav-1. The present study identifies the subset of Rac-1 responses that mediate Vav-1 action as critical regulators of TCRβ selection.

UR - https://www.scopus.com/pages/publications/0034305495

U2 - 10.1038/79808

DO - 10.1038/79808

M3 - Article

C2 - 11017108

AN - SCOPUS:0034305495

SN - 1529-2908

VL - 1

SP - 348

EP - 352

JO - Nature Immunology

JF - Nature Immunology

IS - 4

ER -