Abstract
Vitamin D affects a range of pathophysiological processes pertinent to the control of blood pressure, including endothelial function, inflammation and renin-angiotensin system activity. Observational data show a clear relationship between 25-hydroxyvitamin D levels and both current blood pressure and incident hypertension. However, recent trial data have shown no significant effect of vitamin D supplementation on blood pressure, even at high doses, low vitamin D levels and in patients with high baseline blood pressure. Vitamin D might still benefit cardiovascular health through mechanisms other than blood pressure reduction, but data from large trials are required to show this. In the meantime, vitamin D has no place in controlling blood pressure either at the individual or the population level.
| Original language | English |
|---|---|
| Pages (from-to) | 971-973 |
| Number of pages | 3 |
| Journal | Expert Review of Cardiovascular Therapy |
| Volume | 13 |
| Issue number | 9 |
| DOIs | |
| Publication status | Published - 2015 |
Keywords
- Cardiovascular
- Hypertension
- Meta-analysis
- Trials
- Vitamin D
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
- Internal Medicine
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