Coping with DNA double strand breaks

    Research output: Contribution to journalReview article

    65 Citations (Scopus)

    Abstract

    The repair of DNA double strand breaks (dsb) is important for maintaining the physical and genetic integrity of the genome. Moreover, in humans it is associated with the prevention of diseases such as immune deficiencies and cancer. This review briefly explores the fundamental strategies for repairing dsb, examines how cells maximize the fidelity of dsb repair in the cell cycle and discusses the requirements for dsb repair in the context of chromatin. (C) 2010 Elsevier B.V. All rights reserved.

    Original languageEnglish
    Pages (from-to)1256-1263
    Number of pages8
    JournalDNA Repair
    Volume9
    Issue number12
    DOIs
    Publication statusPublished - 10 Dec 2010

    Keywords

    • DNA repair
    • DNA double strand breaks
    • Non-homologous end-joining
    • Homologous recombination
    • DEPENDENT PROTEIN-KINASE
    • HOLLIDAY JUNCTION RESOLVASE
    • CLASS-SWITCH RECOMBINATION
    • XRCC4-DNA LIGASE-IV
    • V(D)J RECOMBINATION
    • CELL-CYCLE
    • HOMOLOGOUS RECOMBINATION
    • FANCONI-ANEMIA
    • END RESECTION
    • KU PROTEIN

    Cite this

    Hiom, Kevin. / Coping with DNA double strand breaks. In: DNA Repair. 2010 ; Vol. 9, No. 12. pp. 1256-1263.
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    abstract = "The repair of DNA double strand breaks (dsb) is important for maintaining the physical and genetic integrity of the genome. Moreover, in humans it is associated with the prevention of diseases such as immune deficiencies and cancer. This review briefly explores the fundamental strategies for repairing dsb, examines how cells maximize the fidelity of dsb repair in the cell cycle and discusses the requirements for dsb repair in the context of chromatin. (C) 2010 Elsevier B.V. All rights reserved.",
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    Coping with DNA double strand breaks. / Hiom, Kevin.

    In: DNA Repair, Vol. 9, No. 12, 10.12.2010, p. 1256-1263.

    Research output: Contribution to journalReview article

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    AU - Hiom, Kevin

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    N2 - The repair of DNA double strand breaks (dsb) is important for maintaining the physical and genetic integrity of the genome. Moreover, in humans it is associated with the prevention of diseases such as immune deficiencies and cancer. This review briefly explores the fundamental strategies for repairing dsb, examines how cells maximize the fidelity of dsb repair in the cell cycle and discusses the requirements for dsb repair in the context of chromatin. (C) 2010 Elsevier B.V. All rights reserved.

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    KW - Homologous recombination

    KW - DEPENDENT PROTEIN-KINASE

    KW - HOLLIDAY JUNCTION RESOLVASE

    KW - CLASS-SWITCH RECOMBINATION

    KW - XRCC4-DNA LIGASE-IV

    KW - V(D)J RECOMBINATION

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    KW - HOMOLOGOUS RECOMBINATION

    KW - FANCONI-ANEMIA

    KW - END RESECTION

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