Coping with DNA double strand breaks

Kevin Hiom

doi:10.1016/j.dnarep.2010.09.018

Coping with DNA double strand breaks

Kevin Hiom

Research output: Contribution to journal › Review article › peer-review

88 Citations (Scopus)

Abstract

The repair of DNA double strand breaks (dsb) is important for maintaining the physical and genetic integrity of the genome. Moreover, in humans it is associated with the prevention of diseases such as immune deficiencies and cancer. This review briefly explores the fundamental strategies for repairing dsb, examines how cells maximize the fidelity of dsb repair in the cell cycle and discusses the requirements for dsb repair in the context of chromatin. (C) 2010 Elsevier B.V. All rights reserved.

Original language	English
Pages (from-to)	1256-1263
Number of pages	8
Journal	DNA Repair
Volume	9
Issue number	12
DOIs	https://doi.org/10.1016/j.dnarep.2010.09.018
Publication status	Published - 10 Dec 2010

Keywords

DNA repair
DNA double strand breaks
Non-homologous end-joining
Homologous recombination
DEPENDENT PROTEIN-KINASE
HOLLIDAY JUNCTION RESOLVASE
CLASS-SWITCH RECOMBINATION
XRCC4-DNA LIGASE-IV
V(D)J RECOMBINATION
CELL-CYCLE
HOMOLOGOUS RECOMBINATION
FANCONI-ANEMIA
END RESECTION
KU PROTEIN

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.dnarep.2010.09.018

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title = "Coping with DNA double strand breaks",

abstract = "The repair of DNA double strand breaks (dsb) is important for maintaining the physical and genetic integrity of the genome. Moreover, in humans it is associated with the prevention of diseases such as immune deficiencies and cancer. This review briefly explores the fundamental strategies for repairing dsb, examines how cells maximize the fidelity of dsb repair in the cell cycle and discusses the requirements for dsb repair in the context of chromatin. (C) 2010 Elsevier B.V. All rights reserved.",

keywords = "DNA repair, DNA double strand breaks, Non-homologous end-joining, Homologous recombination, DEPENDENT PROTEIN-KINASE, HOLLIDAY JUNCTION RESOLVASE, CLASS-SWITCH RECOMBINATION, XRCC4-DNA LIGASE-IV, V(D)J RECOMBINATION, CELL-CYCLE, HOMOLOGOUS RECOMBINATION, FANCONI-ANEMIA, END RESECTION, KU PROTEIN",

author = "Kevin Hiom",

year = "2010",

month = dec,

day = "10",

doi = "10.1016/j.dnarep.2010.09.018",

language = "English",

volume = "9",

pages = "1256--1263",

journal = "DNA Repair",

issn = "1568-7864",

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T1 - Coping with DNA double strand breaks

AU - Hiom, Kevin

PY - 2010/12/10

Y1 - 2010/12/10

N2 - The repair of DNA double strand breaks (dsb) is important for maintaining the physical and genetic integrity of the genome. Moreover, in humans it is associated with the prevention of diseases such as immune deficiencies and cancer. This review briefly explores the fundamental strategies for repairing dsb, examines how cells maximize the fidelity of dsb repair in the cell cycle and discusses the requirements for dsb repair in the context of chromatin. (C) 2010 Elsevier B.V. All rights reserved.

AB - The repair of DNA double strand breaks (dsb) is important for maintaining the physical and genetic integrity of the genome. Moreover, in humans it is associated with the prevention of diseases such as immune deficiencies and cancer. This review briefly explores the fundamental strategies for repairing dsb, examines how cells maximize the fidelity of dsb repair in the cell cycle and discusses the requirements for dsb repair in the context of chromatin. (C) 2010 Elsevier B.V. All rights reserved.

KW - DNA repair

KW - DNA double strand breaks

KW - Non-homologous end-joining

KW - Homologous recombination

KW - DEPENDENT PROTEIN-KINASE

KW - HOLLIDAY JUNCTION RESOLVASE

KW - CLASS-SWITCH RECOMBINATION

KW - XRCC4-DNA LIGASE-IV

KW - V(D)J RECOMBINATION

KW - CELL-CYCLE

KW - HOMOLOGOUS RECOMBINATION

KW - FANCONI-ANEMIA

KW - END RESECTION

KW - KU PROTEIN

U2 - 10.1016/j.dnarep.2010.09.018

DO - 10.1016/j.dnarep.2010.09.018

M3 - Review article

C2 - 21115283

SN - 1568-7864

VL - 9

SP - 1256

EP - 1263

JO - DNA Repair

JF - DNA Repair

IS - 12

ER -

Coping with DNA double strand breaks

Abstract

Keywords

UN SDGs

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