Coping with DNA double strand breaks

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    72 Citations (Scopus)

    Abstract

    The repair of DNA double strand breaks (dsb) is important for maintaining the physical and genetic integrity of the genome. Moreover, in humans it is associated with the prevention of diseases such as immune deficiencies and cancer. This review briefly explores the fundamental strategies for repairing dsb, examines how cells maximize the fidelity of dsb repair in the cell cycle and discusses the requirements for dsb repair in the context of chromatin. (C) 2010 Elsevier B.V. All rights reserved.

    Original languageEnglish
    Pages (from-to)1256-1263
    Number of pages8
    JournalDNA Repair
    Volume9
    Issue number12
    DOIs
    Publication statusPublished - 10 Dec 2010

    Keywords

    • DNA repair
    • DNA double strand breaks
    • Non-homologous end-joining
    • Homologous recombination
    • DEPENDENT PROTEIN-KINASE
    • HOLLIDAY JUNCTION RESOLVASE
    • CLASS-SWITCH RECOMBINATION
    • XRCC4-DNA LIGASE-IV
    • V(D)J RECOMBINATION
    • CELL-CYCLE
    • HOMOLOGOUS RECOMBINATION
    • FANCONI-ANEMIA
    • END RESECTION
    • KU PROTEIN

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