Cost-effectiveness of acyclovir for varicella infections in immunocompetent patients: A British perspective

Dilip Nathwani, Thomas MacDonald, Peter Davey

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

We reviewed data on a reportable disease in Tayside, Scotland, from 1988 to 1992 to estimate numbers of patients with chickenpox and the frequency of complications requiring hospitalization in adults. Average cost-effectiveness of acyclovir in dollars per day of symptoms avoided is $70 for children with chickenpox, $170 for adults with chickenpox, and $18 for adults with shingles. If acyclovir treatment is 50% effective at reducing admissions, the implied value is $35,262 per admission avoided, whereas data on prevention of postherpetic neuralgia suggest that treating shingles with acyclovir costs $2125 per case of postherpetic neuralgia avoided. We conclude that acyclovir treatment of patients with shingles is much more cost-effective than unselected acyclovir treatment of adults or children with chickenpox.

Original languageEnglish
Pages (from-to)138-145
Number of pages8
JournalInfectious Diseases in Clinical Practice
Volume4
Issue number2
DOIs
Publication statusPublished - 1 Mar 1995

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