Counting sperm does not add up any more

time for a new equation?

Linda Lefièvre, Kweku Bedu-Addo, Sarah J Conner, Gisela S M Machado-Oliveira, Yongjian Chen, Jackson C Kirkman-Brown, Masoud A Afnan, Stephen J Publicover, W Christopher L Ford, Christopher L R Barratt (Lead / Corresponding author)

Research output: Contribution to journalReview article

60 Citations (Scopus)

Abstract

Although sperm dysfunction is the single most common cause of infertility, we have poor methods of diagnosis and surprisingly no effective treatment (excluding assisted reproductive technology). In this review, we challenge the usefulness of a basic semen analysis and argue that a new paradigm is required immediately. We discuss the use of at-home screening to potentially improve the diagnosis of the male and to streamline the management of the sub-fertile couple. Additionally, we outline the recent progress in the field, for example, in proteomics, which will allow the development of new biomarkers of sperm function. This new knowledge will transform our understanding of the spermatozoon as a machine and is likely to lead to non-ART treatments for men with sperm dysfunction.

Original languageEnglish
Pages (from-to)675-684
Number of pages10
JournalReproduction
Volume133
Issue number4
DOIs
Publication statusPublished - 1 Apr 2007

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Spermatozoa
Assisted Reproductive Techniques
Semen Analysis
Proteomics
Infertility
Biomarkers
Therapeutics

Keywords

  • Calcium/metabolism
  • Humans
  • Infertility, Male/diagnosis
  • Male
  • Proteomics
  • Sperm Capacitation/physiology
  • Sperm Count
  • Spermatozoa/cytology

Cite this

Lefièvre, L., Bedu-Addo, K., Conner, S. J., Machado-Oliveira, G. S. M., Chen, Y., Kirkman-Brown, J. C., ... Barratt, C. L. R. (2007). Counting sperm does not add up any more: time for a new equation? Reproduction, 133(4), 675-684. https://doi.org/10.1530/REP-06-0332
Lefièvre, Linda ; Bedu-Addo, Kweku ; Conner, Sarah J ; Machado-Oliveira, Gisela S M ; Chen, Yongjian ; Kirkman-Brown, Jackson C ; Afnan, Masoud A ; Publicover, Stephen J ; Ford, W Christopher L ; Barratt, Christopher L R. / Counting sperm does not add up any more : time for a new equation?. In: Reproduction. 2007 ; Vol. 133, No. 4. pp. 675-684.
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Lefièvre, L, Bedu-Addo, K, Conner, SJ, Machado-Oliveira, GSM, Chen, Y, Kirkman-Brown, JC, Afnan, MA, Publicover, SJ, Ford, WCL & Barratt, CLR 2007, 'Counting sperm does not add up any more: time for a new equation?', Reproduction, vol. 133, no. 4, pp. 675-684. https://doi.org/10.1530/REP-06-0332

Counting sperm does not add up any more : time for a new equation? / Lefièvre, Linda; Bedu-Addo, Kweku; Conner, Sarah J; Machado-Oliveira, Gisela S M; Chen, Yongjian; Kirkman-Brown, Jackson C; Afnan, Masoud A; Publicover, Stephen J; Ford, W Christopher L; Barratt, Christopher L R (Lead / Corresponding author).

In: Reproduction, Vol. 133, No. 4, 01.04.2007, p. 675-684.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Counting sperm does not add up any more

T2 - time for a new equation?

AU - Lefièvre, Linda

AU - Bedu-Addo, Kweku

AU - Conner, Sarah J

AU - Machado-Oliveira, Gisela S M

AU - Chen, Yongjian

AU - Kirkman-Brown, Jackson C

AU - Afnan, Masoud A

AU - Publicover, Stephen J

AU - Ford, W Christopher L

AU - Barratt, Christopher L R

PY - 2007/4/1

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N2 - Although sperm dysfunction is the single most common cause of infertility, we have poor methods of diagnosis and surprisingly no effective treatment (excluding assisted reproductive technology). In this review, we challenge the usefulness of a basic semen analysis and argue that a new paradigm is required immediately. We discuss the use of at-home screening to potentially improve the diagnosis of the male and to streamline the management of the sub-fertile couple. Additionally, we outline the recent progress in the field, for example, in proteomics, which will allow the development of new biomarkers of sperm function. This new knowledge will transform our understanding of the spermatozoon as a machine and is likely to lead to non-ART treatments for men with sperm dysfunction.

AB - Although sperm dysfunction is the single most common cause of infertility, we have poor methods of diagnosis and surprisingly no effective treatment (excluding assisted reproductive technology). In this review, we challenge the usefulness of a basic semen analysis and argue that a new paradigm is required immediately. We discuss the use of at-home screening to potentially improve the diagnosis of the male and to streamline the management of the sub-fertile couple. Additionally, we outline the recent progress in the field, for example, in proteomics, which will allow the development of new biomarkers of sperm function. This new knowledge will transform our understanding of the spermatozoon as a machine and is likely to lead to non-ART treatments for men with sperm dysfunction.

KW - Calcium/metabolism

KW - Humans

KW - Infertility, Male/diagnosis

KW - Male

KW - Proteomics

KW - Sperm Capacitation/physiology

KW - Sperm Count

KW - Spermatozoa/cytology

U2 - 10.1530/REP-06-0332

DO - 10.1530/REP-06-0332

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Lefièvre L, Bedu-Addo K, Conner SJ, Machado-Oliveira GSM, Chen Y, Kirkman-Brown JC et al. Counting sperm does not add up any more: time for a new equation? Reproduction. 2007 Apr 1;133(4):675-684. https://doi.org/10.1530/REP-06-0332