Covalently attached phosphatidylinositol as a hydrophobic anchor for membrane-proteins

Martin G. Low, Michael A. J. Ferguson, Anthony H. Futerman, Israel Silman

    Research output: Contribution to journalReview articlepeer-review

    167 Citations (Scopus)


    Recently a novel mechanism has been described for the hydrophobic attachment of proteins to membranes, which is shared by membrane proteins of widely differing origin and function. The hydrophobic anchor is the 1,2-diacylglycerol moiety of a phosphatidylinositol molecule which is covalently attached to the polypeptide chain. These findings have important structural and functional implications.
    Original languageEnglish
    Pages (from-to)212-215
    Number of pages4
    JournalTrends in Biochemical Sciences
    Issue number5
    Publication statusPublished - 1986


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