TY - JOUR
T1 - Covalently attached phosphatidylinositol as a hydrophobic anchor for membrane-proteins
AU - Low, Martin G.
AU - Ferguson, Michael A. J.
AU - Futerman, Anthony H.
AU - Silman, Israel
PY - 1986
Y1 - 1986
N2 - Recently a novel mechanism has been described for the hydrophobic attachment of proteins to membranes, which is shared by membrane proteins of widely differing origin and function. The hydrophobic anchor is the 1,2-diacylglycerol moiety of a phosphatidylinositol molecule which is covalently attached to the polypeptide chain. These findings have important structural and functional implications.
AB - Recently a novel mechanism has been described for the hydrophobic attachment of proteins to membranes, which is shared by membrane proteins of widely differing origin and function. The hydrophobic anchor is the 1,2-diacylglycerol moiety of a phosphatidylinositol molecule which is covalently attached to the polypeptide chain. These findings have important structural and functional implications.
U2 - 10.1016/0968-0004(86)90009-5
DO - 10.1016/0968-0004(86)90009-5
M3 - Review article
SN - 0968-0004
VL - 11
SP - 212
EP - 215
JO - Trends in Biochemical Sciences
JF - Trends in Biochemical Sciences
IS - 5
ER -