COVID-19-associated acute kidney injury: Consensus report of the 25th Acute Disease Quality Initiative (ADQI) Workgroup

Mitra K. Nadim; Lui G. Forni; Ravindra L. Mehta; Michael J. Connor; Kathleen D. Liu; Marlies Ostermann; Thomas Rimmelé; Alexander Zarbock; Samira Bell; Azra Bihorac; Vincenzo Cantaluppi; Eric Hoste; Faeq Husain-Syed; Michael J. Germain; Stuart L. Goldstein; Shruti Gupta; Michael Joannidis; Kianoush Kashani; Jay L. Koyner; Matthieu Legrand; Nuttha Lumlertgul; Sumit Mohan; Neesh Pannu; Zhiyong Peng; Xose L. Perez-Fernandez; Peter Pickkers; John Prowle; Thiago Reis; Nattachai Srisawat; Ashita Tolwani; Anitha Vijayan; Gianluca Villa; Li Yang; Claudio Ronco; John A. Kellum

doi:10.1038/s41581-020-00356-5

COVID-19-associated acute kidney injury: Consensus report of the 25th Acute Disease Quality Initiative (ADQI) Workgroup

Mitra K. Nadim, Lui G. Forni, Ravindra L. Mehta, Michael J. Connor, Kathleen D. Liu, Marlies Ostermann, Thomas Rimmelé, Alexander Zarbock, Samira Bell, Azra Bihorac, Vincenzo Cantaluppi, Eric Hoste, Faeq Husain-Syed, Michael J. Germain, Stuart L. Goldstein, Shruti Gupta, Michael Joannidis, Kianoush Kashani, Jay L. Koyner, Matthieu LegrandNuttha Lumlertgul, Sumit Mohan, Neesh Pannu, Zhiyong Peng, Xose L. Perez-Fernandez, Peter Pickkers, John Prowle, Thiago Reis, Nattachai Srisawat, Ashita Tolwani, Anitha Vijayan, Gianluca Villa, Li Yang, Claudio Ronco, John A. Kellum (Lead / Corresponding author)

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Abstract

Kidney involvement in patients with coronavirus disease 2019 (COVID-19) is common, and can range from the presence of proteinuria and haematuria to acute kidney injury (AKI) requiring renal replacement therapy (RRT; also known as kidney replacement therapy). COVID-19-associated AKI (COVID-19 AKI) is associated with high mortality and serves as an independent risk factor for all-cause in-hospital death in patients with COVID-19. The pathophysiology and mechanisms of AKI in patients with COVID-19 have not been fully elucidated and seem to be multifactorial, in keeping with the pathophysiology of AKI in other patients who are critically ill. Little is known about the prevention and management of COVID-19 AKI. The emergence of regional ‘surges’ in COVID-19 cases can limit hospital resources, including dialysis availability and supplies; thus, careful daily assessment of available resources is needed. In this Consensus Statement, the Acute Disease Quality Initiative provides recommendations for the diagnosis, prevention and management of COVID-19 AKI based on current literature. We also make recommendations for areas of future research, which are aimed at improving understanding of the underlying processes and improving outcomes for patients with COVID-19 AKI.

Original language	English
Pages (from-to)	747-764
Number of pages	18
Journal	Nature Reviews Nephrology
Volume	16
Issue number	12
Early online date	15 Oct 2020
DOIs	https://doi.org/10.1038/s41581-020-00356-5
Publication status	Published - Dec 2020

Keywords

Acute kidney injury
Infectious diseases
SARS-CoV-2
Scientific community

ASJC Scopus subject areas

Nephrology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1038/s41581-020-00356-5Licence: CC BY

Final Published VersionFinal published version, 1.82 MBLicence: CC BY

Cite this

Nadim, M. K., Forni, L. G., Mehta, R. L., Connor, M. J., Liu, K. D., Ostermann, M., Rimmelé, T., Zarbock, A., Bell, S., Bihorac, A., Cantaluppi, V., Hoste, E., Husain-Syed, F., Germain, M. J., Goldstein, S. L., Gupta, S., Joannidis, M., Kashani, K., Koyner, J. L., ... Kellum, J. A. (2020). COVID-19-associated acute kidney injury: Consensus report of the 25th Acute Disease Quality Initiative (ADQI) Workgroup. Nature Reviews Nephrology, 16(12), 747-764. https://doi.org/10.1038/s41581-020-00356-5

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title = "COVID-19-associated acute kidney injury: Consensus report of the 25th Acute Disease Quality Initiative (ADQI) Workgroup",

abstract = "Kidney involvement in patients with coronavirus disease 2019 (COVID-19) is common, and can range from the presence of proteinuria and haematuria to acute kidney injury (AKI) requiring renal replacement therapy (RRT; also known as kidney replacement therapy). COVID-19-associated AKI (COVID-19 AKI) is associated with high mortality and serves as an independent risk factor for all-cause in-hospital death in patients with COVID-19. The pathophysiology and mechanisms of AKI in patients with COVID-19 have not been fully elucidated and seem to be multifactorial, in keeping with the pathophysiology of AKI in other patients who are critically ill. Little is known about the prevention and management of COVID-19 AKI. The emergence of regional {\textquoteleft}surges{\textquoteright} in COVID-19 cases can limit hospital resources, including dialysis availability and supplies; thus, careful daily assessment of available resources is needed. In this Consensus Statement, the Acute Disease Quality Initiative provides recommendations for the diagnosis, prevention and management of COVID-19 AKI based on current literature. We also make recommendations for areas of future research, which are aimed at improving understanding of the underlying processes and improving outcomes for patients with COVID-19 AKI.",

keywords = "Acute kidney injury, Infectious diseases, SARS-CoV-2, Scientific community",

author = "Nadim, {Mitra K.} and Forni, {Lui G.} and Mehta, {Ravindra L.} and Connor, {Michael J.} and Liu, {Kathleen D.} and Marlies Ostermann and Thomas Rimmel{\'e} and Alexander Zarbock and Samira Bell and Azra Bihorac and Vincenzo Cantaluppi and Eric Hoste and Faeq Husain-Syed and Germain, {Michael J.} and Goldstein, {Stuart L.} and Shruti Gupta and Michael Joannidis and Kianoush Kashani and Koyner, {Jay L.} and Matthieu Legrand and Nuttha Lumlertgul and Sumit Mohan and Neesh Pannu and Zhiyong Peng and Perez-Fernandez, {Xose L.} and Peter Pickkers and John Prowle and Thiago Reis and Nattachai Srisawat and Ashita Tolwani and Anitha Vijayan and Gianluca Villa and Li Yang and Claudio Ronco and Kellum, {John A.}",

year = "2020",

month = dec,

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language = "English",

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journal = "Nature Reviews Nephrology",

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Nadim, MK, Forni, LG, Mehta, RL, Connor, MJ, Liu, KD, Ostermann, M, Rimmelé, T, Zarbock, A, Bell, S, Bihorac, A, Cantaluppi, V, Hoste, E, Husain-Syed, F, Germain, MJ, Goldstein, SL, Gupta, S, Joannidis, M, Kashani, K, Koyner, JL, Legrand, M, Lumlertgul, N, Mohan, S, Pannu, N, Peng, Z, Perez-Fernandez, XL, Pickkers, P, Prowle, J, Reis, T, Srisawat, N, Tolwani, A, Vijayan, A, Villa, G, Yang, L, Ronco, C & Kellum, JA 2020, 'COVID-19-associated acute kidney injury: Consensus report of the 25th Acute Disease Quality Initiative (ADQI) Workgroup', Nature Reviews Nephrology, vol. 16, no. 12, pp. 747-764. https://doi.org/10.1038/s41581-020-00356-5

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T1 - COVID-19-associated acute kidney injury

T2 - Consensus report of the 25th Acute Disease Quality Initiative (ADQI) Workgroup

AU - Nadim, Mitra K.

AU - Forni, Lui G.

AU - Mehta, Ravindra L.

AU - Connor, Michael J.

AU - Liu, Kathleen D.

AU - Ostermann, Marlies

AU - Rimmelé, Thomas

AU - Zarbock, Alexander

AU - Bell, Samira

AU - Bihorac, Azra

AU - Cantaluppi, Vincenzo

AU - Hoste, Eric

AU - Husain-Syed, Faeq

AU - Germain, Michael J.

AU - Goldstein, Stuart L.

AU - Gupta, Shruti

AU - Joannidis, Michael

AU - Kashani, Kianoush

AU - Koyner, Jay L.

AU - Legrand, Matthieu

AU - Lumlertgul, Nuttha

AU - Mohan, Sumit

AU - Pannu, Neesh

AU - Peng, Zhiyong

AU - Perez-Fernandez, Xose L.

AU - Pickkers, Peter

AU - Prowle, John

AU - Reis, Thiago

AU - Srisawat, Nattachai

AU - Tolwani, Ashita

AU - Vijayan, Anitha

AU - Villa, Gianluca

AU - Yang, Li

AU - Ronco, Claudio

AU - Kellum, John A.

PY - 2020/12

Y1 - 2020/12

N2 - Kidney involvement in patients with coronavirus disease 2019 (COVID-19) is common, and can range from the presence of proteinuria and haematuria to acute kidney injury (AKI) requiring renal replacement therapy (RRT; also known as kidney replacement therapy). COVID-19-associated AKI (COVID-19 AKI) is associated with high mortality and serves as an independent risk factor for all-cause in-hospital death in patients with COVID-19. The pathophysiology and mechanisms of AKI in patients with COVID-19 have not been fully elucidated and seem to be multifactorial, in keeping with the pathophysiology of AKI in other patients who are critically ill. Little is known about the prevention and management of COVID-19 AKI. The emergence of regional ‘surges’ in COVID-19 cases can limit hospital resources, including dialysis availability and supplies; thus, careful daily assessment of available resources is needed. In this Consensus Statement, the Acute Disease Quality Initiative provides recommendations for the diagnosis, prevention and management of COVID-19 AKI based on current literature. We also make recommendations for areas of future research, which are aimed at improving understanding of the underlying processes and improving outcomes for patients with COVID-19 AKI.

AB - Kidney involvement in patients with coronavirus disease 2019 (COVID-19) is common, and can range from the presence of proteinuria and haematuria to acute kidney injury (AKI) requiring renal replacement therapy (RRT; also known as kidney replacement therapy). COVID-19-associated AKI (COVID-19 AKI) is associated with high mortality and serves as an independent risk factor for all-cause in-hospital death in patients with COVID-19. The pathophysiology and mechanisms of AKI in patients with COVID-19 have not been fully elucidated and seem to be multifactorial, in keeping with the pathophysiology of AKI in other patients who are critically ill. Little is known about the prevention and management of COVID-19 AKI. The emergence of regional ‘surges’ in COVID-19 cases can limit hospital resources, including dialysis availability and supplies; thus, careful daily assessment of available resources is needed. In this Consensus Statement, the Acute Disease Quality Initiative provides recommendations for the diagnosis, prevention and management of COVID-19 AKI based on current literature. We also make recommendations for areas of future research, which are aimed at improving understanding of the underlying processes and improving outcomes for patients with COVID-19 AKI.

KW - Acute kidney injury

KW - Infectious diseases

KW - SARS-CoV-2

KW - Scientific community

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U2 - 10.1038/s41581-020-00356-5

DO - 10.1038/s41581-020-00356-5

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SN - 1759-5061

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EP - 764

JO - Nature Reviews Nephrology

JF - Nature Reviews Nephrology

IS - 12

ER -

COVID-19-associated acute kidney injury: Consensus report of the 25th Acute Disease Quality Initiative (ADQI) Workgroup

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Publisher Correction: COVID-19-associated acute kidney injury: consensus report of the 25^th Acute Disease Quality Initiative (ADQI) Workgroup (Nature Reviews Nephrology, (2020), 10.1038/s41581-020-00356-5)

Cite this

COVID-19-associated acute kidney injury: Consensus report of the 25th Acute Disease Quality Initiative (ADQI) Workgroup

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Research output

Publisher Correction: COVID-19-associated acute kidney injury: consensus report of the 25th Acute Disease Quality Initiative (ADQI) Workgroup (Nature Reviews Nephrology, (2020), 10.1038/s41581-020-00356-5)

Cite this

Publisher Correction: COVID-19-associated acute kidney injury: consensus report of the 25^th Acute Disease Quality Initiative (ADQI) Workgroup (Nature Reviews Nephrology, (2020), 10.1038/s41581-020-00356-5)