COVID-19 meets Cystic Fibrosis: for better or worse?

Daniel Peckham (Lead / Corresponding author), Michael F. McDermott, Sinisa Savic, Anil Mehta

    Research output: Contribution to journalArticlepeer-review

    3 Citations (Scopus)

    Abstract

    Cystic fibrosis (CF) is one of the most common autosomal recessive life-limiting conditions affecting Caucasians. The resulting defect in the cystic fibrosis transmembrane conductance regulator protein (CFTR) results in defective chloride and bicarbonate secretion, as well as dysregulation of epithelial sodium channels (ENaC). These changes bring about defective mucociliary clearance, reduced airway surface liquid and an exaggerated proinflammatory response driven, in part, by infection. In this short article we explore the overlap in the pathophysiology of CF and COVID-19 infection and discuss how understanding the interaction between both diseases may shed light on future treatments.

    Original languageEnglish
    Number of pages3
    JournalGenes and Immunity
    DOIs
    Publication statusE-pub ahead of print - 1 Jul 2020

    Keywords

    • Biological sciences
    • Genetics

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