Creation of an ovine model of progressive structural lordo-scoliosis using a unilateral laminar tether

John G. Burke, Enzo Vettorato, Gudrun Schöffmann, R. Eddie Clutton, Tim S. Drew, J. N. Alastair Gibson (Lead / Corresponding author)

Research output: Contribution to journalArticle

Abstract

Purpose

To characterise changes in vertebral dimension in an ovine model of scoliosis and determine whether a reproducible curvature could be created that would be suitable for future testing of curve modifying surgical implants.
Methods

At a mean age of 5 weeks, 28 Scottish blackface sheep were anaesthetised. A 4 mm braided synthetic tape was laid under the left lamina of T5 and L1 and tightened to ‘hand’ tension. A scoliosis was then created by binding the six lowest ribs on the same side just distal to their rib angles and resecting a segment from each of the opposite ribs. Radiographs were taken at 4 weekly intervals, and CT images at 2, 5 and 7 months post tethering, to determine multi-planar curve progression. 20 animals were assessed at age 3 months, 12 at 41 weeks and 10 at 1 year with comparisons to five control animals.
Results

A significant bi-planar deformity was produced in all animals (scoliosis 32 ± 13º and lordosis 53 ± 21º 2 months post tethering; mean ± SD, n = 22). During the next 5 months the scoliosis decreased slightly (p = 0.08) but the sagittal deformity remained static: 21 ± 18° and 53 ± 19°, respectively (n = 12). The values at 7 months were associated with a mean 6 ± 4º rotational deformity. There was approximately twice as much growth in the right anterior aspects of the apical vertebrae as in the left posterior.
Conclusions

With appropriate care it was possible to obtain a reproducible curvature in immature sheep. The methods described are ssuitable for use in studies of growth modulation and other spinal device
Original languageEnglish
Pages (from-to)1382-1390
Number of pages9
JournalEuropean Spine Journal
Volume24
Issue number7
Early online date16 Oct 2014
DOIs
Publication statusPublished - Jul 2015

Fingerprint

Structural Models
Scoliosis
Sheep
Ribs
Lordosis
Growth
Spine
Hand
Equipment and Supplies

Cite this

Burke, John G. ; Vettorato, Enzo ; Schöffmann, Gudrun ; Clutton, R. Eddie ; Drew, Tim S. ; Gibson, J. N. Alastair. / Creation of an ovine model of progressive structural lordo-scoliosis using a unilateral laminar tether. In: European Spine Journal. 2015 ; Vol. 24, No. 7. pp. 1382-1390.
@article{6ea85490c78d4cd99174193b955cb89c,
title = "Creation of an ovine model of progressive structural lordo-scoliosis using a unilateral laminar tether",
abstract = "PurposeTo characterise changes in vertebral dimension in an ovine model of scoliosis and determine whether a reproducible curvature could be created that would be suitable for future testing of curve modifying surgical implants.MethodsAt a mean age of 5 weeks, 28 Scottish blackface sheep were anaesthetised. A 4 mm braided synthetic tape was laid under the left lamina of T5 and L1 and tightened to ‘hand’ tension. A scoliosis was then created by binding the six lowest ribs on the same side just distal to their rib angles and resecting a segment from each of the opposite ribs. Radiographs were taken at 4 weekly intervals, and CT images at 2, 5 and 7 months post tethering, to determine multi-planar curve progression. 20 animals were assessed at age 3 months, 12 at 41 weeks and 10 at 1 year with comparisons to five control animals.ResultsA significant bi-planar deformity was produced in all animals (scoliosis 32 ± 13º and lordosis 53 ± 21º 2 months post tethering; mean ± SD, n = 22). During the next 5 months the scoliosis decreased slightly (p = 0.08) but the sagittal deformity remained static: 21 ± 18° and 53 ± 19°, respectively (n = 12). The values at 7 months were associated with a mean 6 ± 4º rotational deformity. There was approximately twice as much growth in the right anterior aspects of the apical vertebrae as in the left posterior.ConclusionsWith appropriate care it was possible to obtain a reproducible curvature in immature sheep. The methods described are ssuitable for use in studies of growth modulation and other spinal device",
author = "Burke, {John G.} and Enzo Vettorato and Gudrun Sch{\"o}ffmann and Clutton, {R. Eddie} and Drew, {Tim S.} and Gibson, {J. N. Alastair}",
year = "2015",
month = "7",
doi = "10.1007/s00586-014-3609-z",
language = "English",
volume = "24",
pages = "1382--1390",
journal = "European Spine Journal",
issn = "0940-6719",
publisher = "Springer Verlag",
number = "7",

}

Creation of an ovine model of progressive structural lordo-scoliosis using a unilateral laminar tether. / Burke, John G.; Vettorato, Enzo; Schöffmann, Gudrun; Clutton, R. Eddie; Drew, Tim S.; Gibson, J. N. Alastair (Lead / Corresponding author).

In: European Spine Journal, Vol. 24, No. 7, 07.2015, p. 1382-1390.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Creation of an ovine model of progressive structural lordo-scoliosis using a unilateral laminar tether

AU - Burke, John G.

AU - Vettorato, Enzo

AU - Schöffmann, Gudrun

AU - Clutton, R. Eddie

AU - Drew, Tim S.

AU - Gibson, J. N. Alastair

PY - 2015/7

Y1 - 2015/7

N2 - PurposeTo characterise changes in vertebral dimension in an ovine model of scoliosis and determine whether a reproducible curvature could be created that would be suitable for future testing of curve modifying surgical implants.MethodsAt a mean age of 5 weeks, 28 Scottish blackface sheep were anaesthetised. A 4 mm braided synthetic tape was laid under the left lamina of T5 and L1 and tightened to ‘hand’ tension. A scoliosis was then created by binding the six lowest ribs on the same side just distal to their rib angles and resecting a segment from each of the opposite ribs. Radiographs were taken at 4 weekly intervals, and CT images at 2, 5 and 7 months post tethering, to determine multi-planar curve progression. 20 animals were assessed at age 3 months, 12 at 41 weeks and 10 at 1 year with comparisons to five control animals.ResultsA significant bi-planar deformity was produced in all animals (scoliosis 32 ± 13º and lordosis 53 ± 21º 2 months post tethering; mean ± SD, n = 22). During the next 5 months the scoliosis decreased slightly (p = 0.08) but the sagittal deformity remained static: 21 ± 18° and 53 ± 19°, respectively (n = 12). The values at 7 months were associated with a mean 6 ± 4º rotational deformity. There was approximately twice as much growth in the right anterior aspects of the apical vertebrae as in the left posterior.ConclusionsWith appropriate care it was possible to obtain a reproducible curvature in immature sheep. The methods described are ssuitable for use in studies of growth modulation and other spinal device

AB - PurposeTo characterise changes in vertebral dimension in an ovine model of scoliosis and determine whether a reproducible curvature could be created that would be suitable for future testing of curve modifying surgical implants.MethodsAt a mean age of 5 weeks, 28 Scottish blackface sheep were anaesthetised. A 4 mm braided synthetic tape was laid under the left lamina of T5 and L1 and tightened to ‘hand’ tension. A scoliosis was then created by binding the six lowest ribs on the same side just distal to their rib angles and resecting a segment from each of the opposite ribs. Radiographs were taken at 4 weekly intervals, and CT images at 2, 5 and 7 months post tethering, to determine multi-planar curve progression. 20 animals were assessed at age 3 months, 12 at 41 weeks and 10 at 1 year with comparisons to five control animals.ResultsA significant bi-planar deformity was produced in all animals (scoliosis 32 ± 13º and lordosis 53 ± 21º 2 months post tethering; mean ± SD, n = 22). During the next 5 months the scoliosis decreased slightly (p = 0.08) but the sagittal deformity remained static: 21 ± 18° and 53 ± 19°, respectively (n = 12). The values at 7 months were associated with a mean 6 ± 4º rotational deformity. There was approximately twice as much growth in the right anterior aspects of the apical vertebrae as in the left posterior.ConclusionsWith appropriate care it was possible to obtain a reproducible curvature in immature sheep. The methods described are ssuitable for use in studies of growth modulation and other spinal device

UR - http://www.scopus.com/record/display.url?eid=2-s2.0-84932609331&origin=resultslist&sort=plf-f&src=s&st1=Creation+of+an+ovine+model+of+progressive+structural+lordo-scoliosis+using+a+unilateral+laminar+tether&st2=&sid=E32D4D35C13E62175E7E871D817BE9D9.WeLimyRvBMk2ky9SFKc8Q%3a300&sot=b&sdt=b&sl=117&s=TITLE-ABS-KEY%28Creation+of+an+ovine+model+of+progressive+structural+lordo-scoliosis+using+a+unilateral+laminar+tether%29&relpos=0&relpos=0&citeCnt=1&searchTerm=TITLE-ABS-KEY%28Creation+of+an+ovine+model+of+progressive+structural+lordo-scoliosis+using+a+unilateral+laminar+tether%29

U2 - 10.1007/s00586-014-3609-z

DO - 10.1007/s00586-014-3609-z

M3 - Article

VL - 24

SP - 1382

EP - 1390

JO - European Spine Journal

JF - European Spine Journal

SN - 0940-6719

IS - 7

ER -