CRISPR-mediated genome editing of Plasmodium falciparum malaria parasites

Marcus C.S. Lee, David A. Fidock

Research output: Contribution to journalArticlepeer-review

28 Citations (Scopus)
23 Downloads (Pure)

Abstract

The development of the CRISPR-Cas system is revolutionizing genome editing in a variety of organisms. The system has now been used to manipulate the genome of Plasmodium falciparum, the most lethal malaria-causing species. The ability to generate gene deletions or nucleotide substitutions rapidly and economically promises to accelerate the analysis of novel drug targets and to help elucidate the function of specific genes or gene families, while complementing genome-wide association studies.

Original languageEnglish
Article number63
Number of pages4
JournalGenome Medicine
Volume6
Issue number8
DOIs
Publication statusPublished - 26 Aug 2014

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Genetics
  • Genetics(clinical)

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