CRISPR-mediated genome editing of Plasmodium falciparum malaria parasites

Marcus C.S. Lee; David A. Fidock

doi:10.1186/s13073-014-0063-9

CRISPR-mediated genome editing of Plasmodium falciparum malaria parasites

Marcus C.S. Lee, David A. Fidock

Biological Chemistry and Drug Discovery

Research output: Contribution to journal › Article › peer-review

29 Citations (Scopus)

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Abstract

The development of the CRISPR-Cas system is revolutionizing genome editing in a variety of organisms. The system has now been used to manipulate the genome of Plasmodium falciparum, the most lethal malaria-causing species. The ability to generate gene deletions or nucleotide substitutions rapidly and economically promises to accelerate the analysis of novel drug targets and to help elucidate the function of specific genes or gene families, while complementing genome-wide association studies.

Original language	English
Article number	63
Number of pages	4
Journal	Genome Medicine
Volume	6
Issue number	8
DOIs	https://doi.org/10.1186/s13073-014-0063-9
Publication status	Published - 26 Aug 2014

ASJC Scopus subject areas

Molecular Medicine
Molecular Biology
Genetics
Genetics(clinical)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1186/s13073-014-0063-9Licence: CC BY

Final published versionFinal published version, 286 KBLicence: CC BY

Cite this

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AB - The development of the CRISPR-Cas system is revolutionizing genome editing in a variety of organisms. The system has now been used to manipulate the genome of Plasmodium falciparum, the most lethal malaria-causing species. The ability to generate gene deletions or nucleotide substitutions rapidly and economically promises to accelerate the analysis of novel drug targets and to help elucidate the function of specific genes or gene families, while complementing genome-wide association studies.

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CRISPR-mediated genome editing of Plasmodium falciparum malaria parasites

Abstract

ASJC Scopus subject areas

UN SDGs

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