CRISPR-mediated genome editing of Plasmodium falciparum malaria parasites

TY - JOUR

T1 - CRISPR-mediated genome editing of Plasmodium falciparum malaria parasites

AU - Lee, Marcus C.S.

AU - Fidock, David A.

N1 - Funding Information: We thank Elizabeth Miller and Andrew Lee for critical reading of the manuscript. DAF gratefully acknowledges support from the US National Institutes of Health (AI50234 and AI109023). Publisher Copyright: © 2014 Lee and Fidock; licensee BioMed Central Ltd.

PY - 2014/8/26

Y1 - 2014/8/26

N2 - The development of the CRISPR-Cas system is revolutionizing genome editing in a variety of organisms. The system has now been used to manipulate the genome of Plasmodium falciparum, the most lethal malaria-causing species. The ability to generate gene deletions or nucleotide substitutions rapidly and economically promises to accelerate the analysis of novel drug targets and to help elucidate the function of specific genes or gene families, while complementing genome-wide association studies.

AB - The development of the CRISPR-Cas system is revolutionizing genome editing in a variety of organisms. The system has now been used to manipulate the genome of Plasmodium falciparum, the most lethal malaria-causing species. The ability to generate gene deletions or nucleotide substitutions rapidly and economically promises to accelerate the analysis of novel drug targets and to help elucidate the function of specific genes or gene families, while complementing genome-wide association studies.

UR - https://www.scopus.com/pages/publications/84906840855

U2 - 10.1186/s13073-014-0063-9

DO - 10.1186/s13073-014-0063-9

M3 - Article

AN - SCOPUS:84906840855

SN - 1756-994X

VL - 6

JO - Genome Medicine

JF - Genome Medicine

IS - 8

M1 - 63

ER -